(Q27758367)

1

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H Kawamoto

2

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T Honma

3

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T Iwama

Proceedings of the National Academy of Sciences of the United States of America

4

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language of work or name

English

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publication date

9 June 1998

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published in

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volume

95

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page(s)

6630-5

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issue

12

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cites work

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The 2.8 A crystal structure of Gla-domainless activated protein C

20 March 2017

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X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition

20 March 2017

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Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design

20 March 2017

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The relative orientation of Gla and EGF domains in coagulation factor X is altered by Ca2+ binding to the first EGF domain. A combined NMR-small angle X-ray scattering study

20 March 2017

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The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

20 March 2017

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Structure of human des(1-45) factor Xa at 2.2 A resolution

20 March 2017

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Crystal structure of human alpha-thrombin complexed with hirugen and p-amidinophenylpyruvate at 1.6 A resolution

20 March 2017

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X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B

20 March 2017

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Crystal structure of a peptidyl pyridinium methyl ketone inhibitor with thrombin

20 March 2017

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Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors

20 March 2017

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Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

20 March 2017

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Crystallographic R factor refinement by molecular dynamics

20 March 2017

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The CCP4 suite: programs for protein crystallography

20 March 2017

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Improved methods for building protein models in electron density maps and the location of errors in these models

20 March 2017

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Molecular cloning of effector cell protease receptor-1, a novel cell surface receptor for the protease factor Xa

20 March 2017

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The coagulation cascade: initiation, maintenance, and regulation

20 March 2017

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Slow-cooling protocols for crystallographic refinement by simulated annealing

20 March 2017

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Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo

7 April 2017

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Activation-dependent exposure of the inter-EGF sequence Leu83-Leu88 in factor Xa mediates ligand binding to effector cell protease receptor-1.

29 September 2017

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Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site

29 September 2017

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Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin

29 September 2017

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Structure-based understanding of ligand affinity using human thrombin as a model system

29 September 2017

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Synthetic low-molecular weight thrombin inhibitors: molecular design and pharmacological profile

29 September 2017

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Proteases and protease receptors in modulation of leukocyte effector functions.

29 September 2017

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How an epidermal growth factor (EGF)-like domain binds calcium. High resolution NMR structure of the calcium form of the NH2-terminal EGF-like domain in coagulation factor X.

29 September 2017

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Crystallographic determination of the structures of human alpha-thrombin complexed with BMS-186282 and BMS-189090

29 September 2017

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Synthetic low-molecular weight thrombin inhibitors: the ideal antithrombotic drug? An introduction.

2 June 2018

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AMoRe: an automated package for molecular replacement

21 January 2018

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Dibasic (Amidinoaryl)propanoic Acid Derivatives as Novel Blood Coagulation Factor Xa Inhibitors

21 January 2018

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DX 9065A a novel, synthetic, selective and orally active inhibitor of factor Xa: in vitro and in vivo studies.

21 January 2018

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Anticoagulant activity of a peptide boronic acid thrombin inhibitor by various routes of administration in rats

27 November 2018

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Highly active and selective anticoagulants: D-Phe-Pro-Arg-H, a free tripeptide aldehyde prone to spontaneous inactivation, and its stable N-methyl derivative, D-MePhe-Pro-Arg-H

21 January 2018

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Effector cell protease receptor-1 is a vascular receptor for coagulation factor Xa.

21 January 2018

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Effector cell protease receptor-1, a platelet activation-dependent membrane protein, regulates prothrombinase-catalyzed thrombin generation

21 January 2018

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Three-dimensional structure of the apo form of the N-terminal EGF-like module of blood coagulation factor X as determined by NMR spectroscopy and simulated folding

21 January 2018

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Molecular recognition at the thrombin active site: structure-based design and synthesis of potent and selective thrombin inhibitors and the X-ray crystal structures of two thrombin-inhibitor complexes

21 January 2018

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The X-ray crystal structure of thrombin in complex with N alpha-2-naphthylsulfonyl-L-3-amidino-phenylalanyl-4-methylpiperidide: the beneficial effect of filling out an empty cavity

21 January 2018

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The structure of a designed peptidomimetic inhibitor complex of alpha-thrombin

21 January 2018

1 reference

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Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.95.12.6630

DX-9065a, a new synthetic, potent anticoagulant and selective inhibitor for factor Xa.

21 January 2018

1 reference

12 December 2020

Inhibition by recombinant hirudins of experimental venous thrombosis and disseminated intravascular coagulation induced by tissue factor in rats

1 reference

12 December 2020

Preparation and properties of derivatives of bovine factor X and factor Xa from which the gamma-carboxyglutamic acid containing domain has been removed

1 reference

12 December 2020

Pharmacological assessment of the antithrombotic activity of the peptide thrombin inhibitor, D-methyl-phenylalanyl-prolyl-arginal (GYKI-14766), in a canine model of coronary artery thrombosis

1 reference

12 December 2020

Comparison of coagulation factor Xa and des-(1-44)factor Xa in the assembly of prothrombinase

1 reference

12 December 2020