(Q30978543)

27 June 2017

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title

The completed human genome: implications for chemical biology (English)

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27 June 2017

Christopher P Austin

1

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27 June 2017

1 August 2003

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Current Opinion in Chemical Biology

27 June 2017

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27 June 2017

7

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27 June 2017

4

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27 June 2017

511-515

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Human genome. Reaching their goal early, sequencing labs celebrate

27 June 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

A vision for the future of genomics research

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https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

A new five-year plan for the U.S. Human Genome Project.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

The Human Genome Project: Lessons from Large-Scale Biology

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https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Lessons learned, promises kept: a biologist's eye view of the Genome Project

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https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Will Genetics Revolutionize Medicine?

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https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Drug discovery with engineered zinc-finger proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

The potential of antisense as a CNS therapeutic

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

The double helix in clinical practice

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Initial sequencing and analysis of the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Comparative analyses of multi-species sequences from targeted genomic regions

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Functional genomic maps in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

1 reference

7 January 2021

Drug discovery: a historical perspective

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https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

A compendium of gene expression in normal human tissues

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Fulfilling the promise: drug discovery in the post-genomic era.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Consortium uses RNAi to uncover genes' function

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https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Knockouts model the 100 best-selling drugs--will they model the next 100?

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https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Drug development. Biotech thinking comes to academic medical centers

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Small molecule modulation of Smoothened activity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

From Knowing to Controlling: A Path from Genomics to Drugs Using Small Molecule Probes

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Novel chemical genetic approaches to the discovery of signal transduction inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Tools for dissecting signaling pathways in vivo: receptors activated solely by synthetic ligands.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

The estrogen receptor: a structure-based approach to the design of new specific hormone-receptor combinations.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Discovery of an ectopic activation site on the M(1) muscarinic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Conditional cell ablation by tight control of caspase-3 dimerization in transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Better therapeutics through microarrays

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Functional discovery via a compendium of expression profiles

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2803%2900083-8

7 January 2021

10.1016/S1367-5931(03)00083-8

Identifiers

DOI

1 reference

27 June 2017

1 reference

PubMed ID

12941427