(Q30981263)

28 June 2017

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title

The quest for molecular quasi-species in ligand-activity space and its application to directed enzyme evolution (English)

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28 June 2017

Bengt Mannervik

1

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28 June 2017

Arna Runarsdottir

series ordinal

2

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28 June 2017

language of work or name

English

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publication date

18 April 2010

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28 June 2017

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28 June 2017

volume

584

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28 June 2017

issue

12

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page(s)

2565-2571

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Exploring protein fitness landscapes by directed evolution

28 June 2017

cites work

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

Enzyme (re)design: lessons from natural evolution and computation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

Transmutation of human glutathione transferase A2-2 with peroxidase activity into an efficient steroid isomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

Structural basis for featuring of steroid isomerase activity in alpha class glutathione transferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

Redesign of substrate-selectivity determining modules of glutathione transferase A1-1 installs high catalytic efficiency with toxic alkenal products of lipid peroxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

Structural Analysis of a Glutathione Transferase A1-1 Mutant Tailored for High Catalytic Efficiency with Toxic Alkenals

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

Enzyme recruitment in evolution of new function

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

Catalytic promiscuity and the evolution of new enzymatic activities

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

Enzymes with extra talents: moonlighting functions and catalytic promiscuity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

Enzyme promiscuity: evolutionary and mechanistic aspects.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

In vitro evolution of beta-glucuronidase into a beta-galactosidase proceeds through non-specific intermediates

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

Directed enzyme evolution: climbing fitness peaks one amino acid at a time

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

Protein promiscuity and its implications for biotechnology

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

Emergence of novel enzyme quasi-species depends on the substrate matrix

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

Functionally diverging molecular quasi-species evolve by crossing two enzymes

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

Identification of residues in glutathione transferase capable of driving functional diversification in evolution. A novel approach to protein redesign

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

Multivariate-activity mining for molecular quasi-species in a glutathione transferase mutant library

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

Multi-substrate-activity space and quasi-species in enzyme evolution: Ohno's dilemma, promiscuity and functional orthogonality

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

21 January 2018

Molecular quasi-species

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

Evolution of differential substrate specificities in Mu class glutathione transferases probed by DNA shuffling

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.04.024

10.1016/J.FEBSLET.2010.04.024

21 January 2018

Identifiers

DOI

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28 June 2017

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