(Q30989535)

16 October 2017

The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2) (English)

1 reference

16 October 2017

protein ubiquitination

1 reference

Sewoon Kim

1

1 reference

16 October 2017

Eek-hoon Jho

series ordinal

2

1 reference

16 October 2017

language of work or name

English

0 references

publication date

21 September 2010

1 reference

Journal of Biological Chemistry

16 October 2017

1 reference

16 October 2017

285

1 reference

16 October 2017

47

1 reference

16 October 2017

36420-36426

1 reference

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

16 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

Regulation of planar cell polarity by Smurf ubiquitin ligases

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

Wnt signalling and its impact on development and cancer

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

The Nedd4-like family of E3 ubiquitin ligases and cancer

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

The many ways of Wnt in cancer

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

14 July 2018

Rethinking WNT signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

Mechanisms underlying ubiquitination

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978571

Ectopic expression of Axin blocks neuronal differentiation of embryonic carcinoma P19 cells

14 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M110.137471

Axin inhibits extracellular signal-regulated kinase pathway by Ras degradation via beta-catenin.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M110.137471

The resolution and characterization of putative ubiquitin carrier protein isozymes from rabbit reticulocytes

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20858899

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Smad7-induced beta-catenin degradation alters epidermal appendage development

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20858899

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.137471

1 reference

16 October 2017

1 reference

16 October 2017

PubMed publication ID

20858899

1 reference