(Q37288448)

English

Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage.

scientific article published on 27 May 2009

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29 January 2020

Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage (English)

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29 January 2020

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29 January 2020

Micheal J Zuscik

5

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29 January 2020

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Qiuqian Wu

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29 January 2020

Erik R Sampson

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29 January 2020

Kyung-O K Kim

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29 January 2020

Regis J O'Keefe

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29 January 2020

Di Chen

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29 January 2020

Randy N Rosier

8

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29 January 2020

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27 May 2009

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29 January 2020

Experimental Cell Research

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29 January 2020

315

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29 January 2020

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29 January 2020

2386-2398

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29 January 2020

Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.

1 reference

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6 September 2017

Inhibition of beta-catenin signaling causes defects in postnatal cartilage development

1 reference

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6 September 2017

Collagen/annexin V interactions regulate chondrocyte mineralization

1 reference

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6 September 2017

Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II

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1 reference

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6 September 2017

Wnt/beta-catenin signaling in development and disease

1 reference

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6 September 2017

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6 September 2017

Cyclin D1-cdk4 induce runx2 ubiquitination and degradation

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6 September 2017

CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling

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6 September 2017

Mechanisms of synovial joint and articular cartilage formation: recent advances, but many lingering mysteries

1 reference

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6 September 2017

Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

The Wnt signaling pathway in development and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

Wnt-7a causes loss of differentiated phenotype and inhibits apoptosis of articular chondrocytes via different mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

Burden of major musculoskeletal conditions.

1 reference

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6 September 2017

High bone density due to a mutation in LDL-receptor-related protein 5

1 reference

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6 September 2017

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

A dominant interference collagen X mutation disrupts hypertrophic chondrocyte pericellular matrix and glycosaminoglycan and proteoglycan distribution in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

TGF-beta signaling by Smad proteins

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

3 September 2018

Growth plate compressions and altered hematopoiesis in collagen X null mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

Transcriptional control by the TGF-beta/Smad signaling system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

Smads: transcriptional activators of TGF-beta responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

6 September 2017

Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis

1 reference

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6 September 2017

Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage

1 reference

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6 September 2017

beta-catenin is a target for the ubiquitin-proteasome pathway

1 reference

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6 September 2017

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

1 reference

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6 September 2017

Abnormal compartmentalization of cartilage matrix components in mice lacking collagen X: implications for function

1 reference

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6 September 2017

Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay

1 reference

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6 September 2017

The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain

1 reference

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1 reference

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1 reference

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26 June 2018

Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin

1 reference

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3 September 2018

Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors.

1 reference

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3 September 2018

Frizzled-related protein variants are risk factors for hip osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

3 September 2018

Interaction of Ihh and BMP/Noggin signaling during cartilage differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

3 September 2018

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3 September 2018

Immunolocalization of type X collagen before and after mineralization of human thyroid cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

3 September 2018

Chondrocyte hypertrophy can be induced by a cryptic sequence of type II collagen and is accompanied by the induction of MMP-13 and collagenase activity: Implications for development and arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720571

3 December 2018

BMPs are required at two steps of limb chondrogenesis: formation of prechondrogenic condensations and their differentiation into chondrocytes

1 reference

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Gene expression and distribution of connective tissue growth factor (CCN2/CTGF) during secondary ossification center formation

1 reference

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7 January 2021

Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy

1 reference

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7 January 2021

Immunolocalization of type X collagen in normal fetal and adult osteoarthritic cartilage with monoclonal antibodies

1 reference

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7 January 2021

Expression of type-X collagen in osteoarthritis

1 reference

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7 January 2021

Effect of transforming growth factor-beta and platelet-derived growth factor-BB on articular cartilage in rats

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.05.019

7 January 2021

Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections

1 reference

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7 January 2021

Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites

1 reference

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7 January 2021

Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice

1 reference

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7 January 2021

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7 January 2021

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19481076

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of transforming growth factors beta 1, beta 2, beta 3 and beta 5 on chondrogenesis in mouse limb bud mesenchymal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19481076

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collagenase-3 (matrix metalloprotease 13) is preferentially localized in the deep layer of human arthritic cartilage in situ: in vitro mimicking effect by transforming growth factor beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/19481076

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteoarthritic lesions: involvement of three different collagenases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19481076

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.YEXCR.2009.05.019

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19481076%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19481076%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19481076%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

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