(Q31019492)

13 November 2017

Predicting drug-induced hepatotoxicity using QSAR and toxicogenomics approaches (English)

1 reference

13 November 2017

1 reference

1 reference

10

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13 November 2017

13

Alexander Tropsha

1 reference

13 November 2017

8

Eugene Muratov

1 reference

13 November 2017

Yen Low

1

1 reference

13 November 2017

Takeki Uehara

2

1 reference

13 November 2017

Yohsuke Minowa

3

1 reference

13 November 2017

Hiroshi Yamada

4

1 reference

13 November 2017

Yasuo Ohno

5

1 reference

13 November 2017

Tetsuro Urushidani

6

1 reference

13 November 2017

Alexander Sedykh

7

1 reference

13 November 2017

Viktor Kuz'min

9

1 reference

13 November 2017

Hao Zhu

11

1 reference

13 November 2017

Ivan Rusyn

12

1 reference

13 November 2017

21 July 2011

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Chemical Research in Toxicology

13 November 2017

1 reference

13 November 2017

24

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13 November 2017

8

1 reference

13 November 2017

1251-1262

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Per aspera ad astra: application of Simplex QSAR approach in antiviral research

13 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Trust, but verify: on the importance of chemical structure curation in cheminformatics and QSAR modeling research

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Use of transcriptomics in understanding mechanisms of drug-induced toxicity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Modeling liver-related adverse effects of drugs using knearest neighbor quantitative structure-activity relationship method

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

The Japanese toxicogenomics project: application of toxicogenomics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

c-Myc and eIF4F constitute a feedforward loop that regulates cell growth: implications for anticancer therapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Use of cell viability assay data improves the prediction accuracy of conventional quantitative structure-activity relationship models of animal carcinogenicity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Predictive QSAR modeling workflow, model applicability domains, and virtual screening

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Profiling of gene expression in rat liver and rat primary cultured hepatocytes treated with peroxisome proliferators

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

On Outliers and Activity Cliffs - Why QSAR Often Disappoints

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

ER stress: can the liver cope?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Why drugs fail--a study on side effects in new chemical entities.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

A safety assessment of coumarin taking into account species-specificity of toxicokinetics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Mechanisms of benzarone and benzbromarone-induced hepatic toxicity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Metabolic detoxification determines species differences in coumarin-induced hepatotoxicity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Significance analysis of microarrays applied to the ionizing radiation response

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Determination of in vivo adducts of disulfiram with mitochondrial aldehyde dehydrogenase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Carbon tetrachloride hepatotoxicity: an example of lethal cleavage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Metabolic activation and toxicity of acetaminophen and related analogs. A theoretical study

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Metabolism of methimazole by rat liver cytochrome P-450-containing monoxygenases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Gene expression profiling in rat liver treated with compounds inducing elevation of bilirubin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Gene expression profiling in rat liver treated with various hepatotoxic-compounds inducing coagulopathy.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Gene expression profiling in rat liver treated with compounds inducing phospholipidosis

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Identification of glutathione depletion-responsive genes using phorone-treated rat liver

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

A gene expression biomarker provides early prediction and mechanistic assessment of hepatic tumor induction by nongenotoxic chemicals

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Combinatorial QSAR of ambergris fragrance compounds.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Novel variable selection quantitative structure--property relationship approach based on the k-nearest-neighbor principle

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Genotoxicity studies of benzofuran dioxetanes and epoxides with isolated DNA, bacteria and mammalian cells

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281093

Application of random forest approach to QSAR prediction of aquatic toxicity

25 November 2018

1 reference

12 December 2020

Studies on the mechanism of coumarin-induced toxicity in rat hepatocytes: comparison with dihydrocoumarin and other coumarin metabolites

1 reference

12 December 2020

Disposition and oxidative metabolism of phenylbutazone in man

1 reference

12 December 2020

Structure-ADME relationship: still a long way to go?

1 reference

12 December 2020

Acute hepatotoxicity: a predictive model based on focused illumina microarrays

1 reference

12 December 2020

Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses

1 reference

12 December 2020

A structural analogue approach to the prediction of the octanol-water partition coefficient

1 reference

12 December 2020

Hierarchical QSAR technology based on the Simplex representation of molecular structure

1 reference

12 December 2020

ISIDA - Platform for Virtual Screening Based on Fragment and Pharmacophoric Descriptors

1 reference

13 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/TX200148A

Best Practices for QSAR Model Development, Validation, and Exploitation

1 reference

13 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/TX200148A

Identifiers

DOI

10.1021/TX200148A

1 reference

13 November 2017

1 reference

13 November 2017

1 reference