(Q31023855)

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Identification of Cathepsin B as a Mediator of Neuronal Death Induced by Aβ-activated Microglial Cells Using a Functional Genomics Approach

scientific article published on November 10, 2003

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scholarly article

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Europe PubMed Central

PubMed publication ID

28 June 2017

Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

Identification of Cathepsin B as a Mediator of Neuronal Death Induced by Aβ-activated Microglial Cells Using a Functional Genomics Approach (English)

1 reference

10.1074/JBC.M306183200

https://api.crossref.org/works/10.1074/JBC.M306183200

31 March 2024

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functional genomics

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based on heuristic

inferred from title

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10.1074/JBC.M306183200

https://api.crossref.org/works/10.1074/JBC.M306183200

31 March 2024

1 reference

10.1074/JBC.M306183200

https://api.crossref.org/works/10.1074/JBC.M306183200

31 March 2024

Joseph C Murray

9

object named as

Joseph Murray

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14612454

31 March 2024

author name string

Li Gan

1

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Europe PubMed Central

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28 June 2017

Shiming Ye

2

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Europe PubMed Central

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28 June 2017

Alan Chu

3

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Europe PubMed Central

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28 June 2017

Kristin Anton

4

1 reference

Europe PubMed Central

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28 June 2017

Saili Yi

5

1 reference

Europe PubMed Central

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28 June 2017

David von Schack

7

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Europe PubMed Central

PubMed publication ID

28 June 2017

Daniel Chin

8

1 reference

Europe PubMed Central

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28 June 2017

Scott Lohr

10

1 reference

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28 June 2017

Laszlo Patthy

11

1 reference

Europe PubMed Central

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28 June 2017

Mirella Gonzalez-Zulueta

12

1 reference

Europe PubMed Central

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28 June 2017

Karoly Nikolich

13

1 reference

Europe PubMed Central

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28 June 2017

Roman Urfer

14

1 reference

Europe PubMed Central

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28 June 2017

Valerie A. Vincent

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14612454

31 March 2024

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publication date

10 November 2003

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Europe PubMed Central

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28 June 2017

number of pages

8

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full work available at URL

http://www.jbc.org/article/S0021925820748891/pdf

Portable Document Format

online access status

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14612454

31 March 2024

https://api.elsevier.com/content/article/PII:S0021925820748891?httpAccept=text/xml

1 reference

10.1074/JBC.M306183200

https://api.crossref.org/works/10.1074/JBC.M306183200

31 March 2024

https://api.elsevier.com/content/article/PII:S0021925820748891?httpAccept=text/plain

1 reference

10.1074/JBC.M306183200

https://api.crossref.org/works/10.1074/JBC.M306183200

31 March 2024

https://syndication.highwire.org/content/doi/10.1074/jbc.M306183200

1 reference

10.1074/JBC.M306183200

https://api.crossref.org/works/10.1074/JBC.M306183200

31 March 2024

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

279

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Europe PubMed Central

PubMed publication ID

28 June 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

5565-5572

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

Alzheimer's disease is a synaptic failure

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Interaction of Alzheimer beta-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-alpha

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Increased levels of alpha-1-antichymotrypsin in brains of patients with Alzheimer's disease correlate with activated astrocytes and are affected by APOE 4 genotype

1 reference

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Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia

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Beta-amyloid peptide potentiates inflammatory responses induced by lipopolysaccharide, interferon -gamma and 'advanced glycation endproducts' in a murine microglia cell line

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Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease.

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Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain.

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Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus

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Accelerated phagocytosis of amyloid-beta by mouse and human microglia overexpressing the macrophage colony-stimulating factor receptor

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Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

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Growth of a rat neuroblastoma cell line in serum-free supplemented medium

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Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries

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Gene ontology: tool for the unification of biology

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A new mathematical model for relative quantification in real-time RT-PCR

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beta-Amyloid induces increased release of interleukin-1 beta from lipopolysaccharide-activated human monocytes

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21 January 2018

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

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21 January 2018

Amyloid beta protein enhances the survival of hippocampal neurons in vitro

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21 January 2018

In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity

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21 January 2018

Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide

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21 January 2018

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

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21 January 2018

Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain

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21 January 2018

Detection of lysosomal cysteine proteinases in microglia: flow cytometric measurement and histochemical localization of cathepsin B and L.

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21 January 2018

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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21 January 2018

Inflammation in neurodegenerative disease--a double-edged sword

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21 January 2018

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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21 January 2018

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

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21 January 2018

Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells.

1 reference

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21 January 2018

Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

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Significance of cathepsin B accumulation in synovial fluid of rheumatoid arthritis

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Kininogenase activity by the major cysteinyl proteinase (cruzipain) from Trypanosoma cruzi

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Microglial secreted cathepsin B induces neuronal apoptosis.

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Microglial apoptosis induced by chromogranin A is mediated by mitochondrial depolarisation and the permeability transition but not by cytochrome c release

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Evidence that inhibition of cathepsin-B contributes to the neuroprotective properties of caspase inhibitor Tyr-Val-Ala-Asp-chloromethyl ketone.

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Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

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Amyloid beta plaque-associated proteins C1q and SAP enhance the Abeta1-42 peptide-induced cytokine secretion by adult human microglia in vitro.

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Cellular and Molecular Biology

48

48

151

author name string

Siao

publication date

2002

1 reference

10.1074/JBC.M306183200

https://api.crossref.org/works/10.1074/JBC.M306183200

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Microglial cathepsin B: an immunological examination of cellular and secreted species.

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Identifiers

10.1074/JBC.M306183200

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

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