(Q31024172)

English

Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties (English)

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

author name string

Bernard L Flynn

1

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Gurmit S Gill

2

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Damian W Grobelny

3

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Jason H Chaplin

4

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Dharam Paul

5

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Annabell F Leske

6

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Tina C Lavranos

7

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

David K Chalmers

8

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Susan A Charman

9

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Edmund Kostewicz

10

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

David M Shackleford

11

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Julia Morizzi

12

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Ernest Hamel

13

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

M Katherine Jung

14

1 reference

Europe PubMed Central

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2 September 2017

Gabriel Kremmidiotis

15

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

language of work or name

0 references

publication date

5 August 2011

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Europe PubMed Central

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2 September 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

PMC publication ID

2 September 2017

54

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

17

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

6014-6027

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Phase 1 first-in-human trial of the vascular disrupting agent plinabulin(NPI-2358) in patients with solid tumors or lymphomas

1 reference

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21 June 2018

ASA404: a tumor vascular-disrupting agent with broad potential for cancer therapy.

1 reference

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21 June 2018

Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance

1 reference

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21 June 2018

Combretastatin A4 Phosphate: A Novel Vascular Disrupting Agent

1 reference

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21 June 2018

Phase I trial of CYT997, a novel cytotoxic and vascular-disrupting agent.

1 reference

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21 June 2018

4-(3-Halo/amino-4,5-dimethoxyphenyl)-5-aryloxazoles and -N-methylimidazoles That Are Cytotoxic against Combretastatin A Resistant Tumor Cells and Vascular Disrupting in a Cisplatin Resistant Germ Cell Tumor Model

1 reference

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21 June 2018

Identification of CKD-516: A Potent Tubulin Polymerization Inhibitor with Marked Antitumor Activity against Murine and Human Solid Tumors

1 reference

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21 June 2018

Substituted 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172808

21 June 2018

BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172808

21 June 2018

Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues

1 reference

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21 June 2018

A Phase Ib trial of CA4P (combretastatin A-4 phosphate), carboplatin, and paclitaxel in patients with advanced cancer

1 reference

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21 June 2018

Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance

1 reference

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21 June 2018

Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17-O,O-bis-sulfamate

1 reference

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21 June 2018

Disrupting established tumor blood vessels: an emerging therapeutic strategy for cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172808

21 June 2018

From signaling pathways to microtubule dynamics: the key players.

1 reference

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21 June 2018

Taxanes: optimizing adjuvant chemotherapy for early-stage breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172808

21 June 2018

Vascular disrupting activity of tubulin-binding 1,5-diaryl-1H-imidazoles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172808

21 June 2018

Design, synthesis, and biological evaluations of 2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoline analogs of combretastatin-A4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172808

21 June 2018

Recent development and SAR analysis of colchicine binding site inhibitors

1 reference

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21 June 2018

New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172808

21 June 2018

Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach.

1 reference

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21 June 2018

On and around microtubules: an overview

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172808

21 June 2018

Multidrug resistance through the spectacle of P-glycoprotein.

1 reference

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21 June 2018

Antivascular actions of microtubule-binding drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172808

21 June 2018

Discovery of 4-substituted methoxybenzoyl-aryl-thiazole as novel anticancer agents: synthesis, biological evaluation, and structure-activity relationships

1 reference

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21 June 2018

Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3',4',5'-trimethoxybenzoyl)-1H-indole (BPR0L075), as potential antivascular agents.

1 reference

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21 June 2018

Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma.

1 reference

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21 June 2018

Combretastatin a-4 analogs as anticancer agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172808

21 June 2018

Phase I clinical evaluation of ZD6126, a novel vascular-targeting agent, in patients with solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172808

21 June 2018

Tumour targeting by microtubule-depolymerizing vascular disrupting agents

1 reference

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21 June 2018

Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin

1 reference

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21 June 2018

Vascular disrupting agents in clinical development

1 reference

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21 June 2018

The concise synthesis of chalcone, indanone and indenone analogues of combretastatin A4.

1 reference

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21 June 2018

Vascular disrupting agents

1 reference

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21 June 2018

Colchicine today

1 reference

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21 June 2018

Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes

1 reference

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21 June 2018

Medicinal chemistry of combretastatin A4: present and future directions.

1 reference

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21 June 2018

Disrupting tumour blood vessels

1 reference

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21 June 2018

Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.

1 reference

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21 June 2018

Combretastatin A4 phosphate: background and current clinical status

1 reference

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21 June 2018

Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172808

21 June 2018

Vascular-targeting therapies for treatment of malignant disease.

1 reference

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21 June 2018

Microtubules as a target for anticancer drugs

1 reference

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21 June 2018

Tubulin and microtubules as targets for anticancer drugs

1 reference

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21 June 2018

Synthesis and biological evaluation of 2'-methyl taxoids derived from baccatin III and 14beta-OH-baccatin III 1,14-carbonate

1 reference

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21 June 2018

Oxi4503, a novel vascular targeting agent: effects on blood flow and antitumor activity in comparison to combretastatin A-4 phosphate.

1 reference

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21 June 2018

Evaluation of antimitotic agents by quantitative comparisons of their effects on the polymerization of purified tubulin

1 reference

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21 June 2018

ZD6126: a novel small molecule vascular targeting agent

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Anticancer therapy with novel tubulin-interacting drugs

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21 June 2018

Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity.

1 reference

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1 reference

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25 November 2018

Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.

1 reference

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25 November 2018

Altered angiogenesis and survival in human tumor-derived endothelial cells.

1 reference

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25 November 2018

ZD6126: a novel vascular-targeting agent that causes selective destruction of tumor vasculature.

1 reference

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25 November 2018

One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization

1 reference

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25 November 2018

The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4.

1 reference

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25 November 2018

Novel combretastatin analogues effective against murine solid tumors: design and structure-activity relationships

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Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells.

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25 November 2018

The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21774499

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A review and update of the current status of the vasculature-disabling agent combretastatin-A4 phosphate (CA4P)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21774499

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel palladium-mediated coupling approach to 2,3-disubstituted benzo(b)thiophenes and its application to the synthesis of tubulin binding agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/21774499

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An efficient synthesis and substitution of 3-aroyl-2-bromobenzo[b]furans

1 reference

https://pubmed.ncbi.nlm.nih.gov/21774499

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylcolchinol O-methyl ether and thiocolchicine, potent analogs of colchicine modified in the C ring. Evaluation of the mechanistic basis for their enhanced biological properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/21774499

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A multi-component coupling approach to benzo[b]furans and indoles

1 reference

https://pubmed.ncbi.nlm.nih.gov/21774499

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new anti-tubulin agent containing the benzo[b]thiophene ring system

1 reference

https://pubmed.ncbi.nlm.nih.gov/21774499

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM200454Y

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

ResearchGate publication ID

0 references

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