(Q37008845)

17 August 2017

1 reference

title

Tumour targeting by microtubule-depolymerizing vascular disrupting agents (English)

1 reference

17 August 2017

2

Gillian M Tozer

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17 August 2017

Chryso Kanthou

1

1 reference

17 August 2017

language of work or name

English

0 references

publication date

1 November 2007

1 reference

Expert Opinion on Therapeutic Targets

17 August 2017

published in

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17 August 2017

volume

11

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17 August 2017

issue

11

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17 August 2017

page(s)

1443-1457

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What Is the Evidence That Tumors Are Angiogenesis Dependent?

17 August 2017

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Disrupting tumour blood vessels

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Tumour vascular targeting

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Vascular damaging agents

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Microtubule-targeting agents in angiogenesis: where do we stand?

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Vinca alkaloids: anti-vascular effects in a murine tumour

21 January 2018

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Antineoplastic agents, 122. Constituents of Combretum caffrum

21 January 2018

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Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4.

21 January 2018

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Effects of combretastatin on murine tumours monitored by 31P MRS, 1H MRS and 1H MRI.

21 January 2018

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Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: effects on radiation therapy.

21 January 2018

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Interaction between combretastatin A-4 disodium phosphate and radiation in murine tumors

21 January 2018

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Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy

21 January 2018

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Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system

21 January 2018

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Intravital imaging of tumour vascular networks using multi-photon fluorescence microscopy

21 January 2018

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Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate

21 January 2018

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Tumour parameters affected by combretastatin A-4 phosphate therapy in a human colorectal xenograft model in nude mice

21 January 2018

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Combretastatin A-4 prodrug inhibits growth of human non-small cell lung cancer in a murine xenotransplant model

21 January 2018

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Combretastatin family member OXI4503 induces tumor vascular collapse through the induction of endothelial apoptosis

21 January 2018

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Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors.

21 January 2018

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Efficacy of combined antiangiogenic and vascular disrupting agents in treatment of solid tumors

21 January 2018

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Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: magnetic resonance imaging evidence for altered tumor blood flow

21 January 2018

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Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results

21 January 2018

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Assessment of pharmacodynamic vascular response in a phase I trial of combretastatin A4 phosphate

21 January 2018

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Combretastatin A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging

21 January 2018

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Microtubules as a target for anticancer drugs

21 January 2018

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Understanding microtubule dynamics for improved cancer therapy.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Dynamic instability of microtubule growth

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Functional cooperation between the microtubule and actin cytoskeletons

21 January 2018

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Microtubules and signal transduction

21 January 2018

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Antiangiogenic concentrations of vinflunine increase the interphase microtubule dynamics and decrease the motility of endothelial cells.

21 January 2018

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In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug

21 January 2018

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Rho family proteins: coordinating cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Myosin light chain kinase: an actin-binding protein that regulates an ATP-dependent interaction with myosin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Dysregulation of the endothelial cellular response to oxidative stress in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Selective activation of p38 MAPK cascade and mitotic arrest caused by low level oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

MZ3 induces apoptosis in human leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Rho GTPases and the regulation of endothelial permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Microtubule depolymerization rapidly collapses capillary tube networks in vitro and angiogenic vessels in vivo through the small GTPase Rho.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Vascular targeting effect of combretastatin A-4 phosphate dominates the inherent angiogenesis inhibitory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Rac regulates endothelial morphogenesis and capillary assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Multifaceted role of Rho proteins in angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Temporal and spatial modulation of Rho GTPases during in vitro formation of capillary vascular network. Adherens junctions and myosin light chain as targets of Rac1 and RhoA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Matrix-specific activation of Src and Rho initiates capillary morphogenesis of endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Rho activity critically and selectively regulates endothelial cell organization during angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Regulation of microtubule dynamics in 3T3 fibroblasts by Rho family GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Rho guanosine triphosphatase mediates the selective stabilization of microtubules induced by lysophosphatidic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

mDia mediates Rho-regulated formation and orientation of stable microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Conserved microtubule-actin interactions in cell movement and morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Selective stabilization of microtubules oriented toward the direction of cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Actin and microtubules in cell motility: which one is in control?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

The tubulin-binding agent combretastatin A-4-phosphate arrests endothelial cells in mitosis and induces mitotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

The spindle assembly checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Schedule dependence of combretastatin A4 phosphate in transplanted and spontaneous tumour models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Signaling mechanisms regulating endothelial permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

RhoGDI-1 modulation of the activity of monomeric RhoGTPase RhoA regulates endothelial barrier function in mouse lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Microvascular mechanisms by which the combretastatin A-4 derivative AC7700 (AVE8062) induces tumour blood flow stasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Rocks: multifunctional kinases in cell behaviour

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Phase I clinical evaluation of weekly administration of the novel vascular-targeting agent, ZD6126, in patients with solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

On the origin and nature of elevated levels of circulating endothelial cells after treatment with a vascular disrupting agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Determinants of anti-vascular action by combretastatin A-4 phosphate: role of nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Molecular regulation of vessel maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Rac and Rho play opposing roles in the regulation of hypoxia/reoxygenation-induced permeability changes in pulmonary artery endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Rac1 and RhoA as regulators of endothelial phenotype and barrier function in hypoxia-induced neonatal pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Hypoxia and the regulation of mitogen-activated protein kinases: gene transcription and the assessment of potential pharmacologic therapeutic interventions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Endothelial-cell proliferation in experimental tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Genes expressed in human tumor endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Anti-vascular agent Combretastatin A-4-P modulates hypoxia inducible factor-1 and gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Regulation of leading edge microtubule and actin dynamics downstream of Rac1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

10.1517/14728222.11.11.1443

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference