(Q31038437)

28 June 2017

title

Application of parallel liquid chromatography/mass spectrometry for high throughput microsomal stability screening of compound libraries (English)

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28 June 2017

Rongda Xu

1

1 reference

28 June 2017

Csaba Nemes

2

1 reference

28 June 2017

Kelly M Jenkins

3

1 reference

28 June 2017

Robyn A Rourick

4

1 reference

28 June 2017

Daniel B Kassel

5

1 reference

28 June 2017

Charles Z C Liu

6

1 reference

28 June 2017

publication date

1 February 2002

1 reference

Journal of the American Society for Mass Spectrometry

28 June 2017

published in

1 reference

28 June 2017

volume

13

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28 June 2017

issue

2

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28 June 2017

page(s)

155-165

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Approaches to higher-throughput pharmacokinetics (HTPK) in drug discovery

28 June 2017

cites work

1 reference

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Property-based design: optimization of drug absorption and pharmacokinetics

21 January 2018

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Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry.

21 January 2018

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High-throughput bioanalytical LC/MS/MS determination of benzodiazepines in human urine: 1000 samples per 12 hours

21 January 2018

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Use of Caco-2 cells and LC/MS/MS to screen a peptide combinatorial library for permeable structures

21 January 2018

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21 January 2018

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The development of a staggered parallel separation liquid chromatography/tandem mass spectrometry system with on-line extraction for high-throughout screening of drug candidates in biological fluids

21 January 2018

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A high-capacity LC/MS system for the bioanalysis of samples generated from plate-based metabolic screening

21 January 2018

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Evaluation of a four-channel multiplexed electrospray triple quadrupole mass spectrometer for the simultaneous validation of LC/MS/MS methods in four different preclinical matrixes

21 January 2018

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Automation of metabolic stability studies in microsomes, cytosol and plasma using a 215 Gilson liquid handler

21 January 2018

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Development of an automated mass spectrometry system for the quantitative analysis of liver microsomal incubation samples: a tool for rapid screening of new compounds for metabolic stability

21 January 2018

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Optimisation and routine use of generic ultra-high flow-rate liquid chromatography with mass spectrometric detection for the direct on-line analysis of pharmaceuticals in plasma

21 January 2018

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Bioanalytical high-throughput selected reaction monitoring-LC/MS determination of selected estrogen receptor modulators in human plasma: 2000 samples/day

21 January 2018

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Use of "N-in-One" dosing to create an in vivo pharmacokinetics database for use in developing structure-pharmacokinetic relationships

21 January 2018

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Novel procedure for rapid pharmacokinetic screening of discovery compounds in rats

21 January 2018

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Demonstration of the capabilities of a parallel high performance liquid chromatography tandem mass spectrometry system for use in the analysis of drug discovery plasma samples

21 January 2018

1 reference

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Application of a non-indexed dual sprayer pneumatically assisted electrospray source to the high throughput quantitation of target compounds in biological fluids

21 January 2018

1 reference

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Parallel ultra-high flow rate liquid chromatography with mass spectrometric detection using a multiplex electrospray source for direct, sensitive determination of pharmaceuticals in plasma at extremely high throughput

21 January 2018

1 reference

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A multiple electrospray interface for parallel mass spectrometric analyses of compound libraries

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11841071

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Drug selection in early drug development: screening for acceptable pharmacokinetic properties using combined in vitro and computational approaches

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11841071

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/S1044-0305(01)00342-7

1 reference

Dimensions Publication ID

28 June 2017

1039407737

0 references

1 reference