(Q31106131)

English

Ex vivo evidence for the contribution of hemodynamic shear stress abnormalities to the early pathogenesis of calcific bicuspid aortic valve disease

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

4 October 2017

Ex vivo evidence for the contribution of hemodynamic shear stress abnormalities to the early pathogenesis of calcific bicuspid aortic valve disease (English)

1 reference

Europe PubMed Central

PMC publication ID

4 October 2017

0 references

0 references

aortic valve disease

1 reference

based on heuristic

inferred from title

bicuspid aortic valve

1 reference

based on heuristic

inferred from title

Philippe Sucosky

object named as

Philippe Sucosky

3

0 references

author name string

Ling Sun

1

1 reference

Europe PubMed Central

PMC publication ID

4 October 2017

Santanu Chandra

2

1 reference

Europe PubMed Central

PMC publication ID

4 October 2017

language of work or name

0 references

publication date

31 October 2012

1 reference

Europe PubMed Central

PMC publication ID

4 October 2017

1 reference

Europe PubMed Central

PMC publication ID

4 October 2017

7

1 reference

Europe PubMed Central

PMC publication ID

4 October 2017

10

1 reference

Europe PubMed Central

PMC publication ID

4 October 2017

e48843

1 reference

Europe PubMed Central

PMC publication ID

4 October 2017

copyright license

Creative Commons Attribution 4.0 International

31 October 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3485349/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

The congenital bicuspid aortic valve can experience high-frequency unsteady shear stresses on its leaflet surface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Can valvular interstitial cells become true osteoblasts? A side-by-side comparison.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Hemodynamics and mechanobiology of aortic valve inflammation and calcification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Calcific aortic valve stenosis: methods, models, and mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Experimental measurement of dynamic fluid shear stress on the ventricular surface of the aortic valve leaflet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Design and validation of a novel bioreactor to subject aortic valve leaflets to side-specific shear stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Elevated cyclic stretch induces aortic valve calcification in a bone morphogenic protein-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Bicuspid aortic valve: four-dimensional MR evaluation of ascending aortic systolic flow patterns

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Quantification of hemodynamic wall shear stress in patients with bicuspid aortic valve using phase-contrast MRI

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Mechano-potential etiologies of aortic valve disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Calcific aortic stenosis: lessons learned from experimental and clinical studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Altered shear stress stimulates upregulation of endothelial VCAM-1 and ICAM-1 in a BMP-4- and TGF-beta1-dependent pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Cyclic strain regulates pro-inflammatory protein expression in porcine aortic valve endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Molecular mechanisms underlying the onset of degenerative aortic valve disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Mechanobiology of the aortic heart valve

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Insights into degenerative aortic valve disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Synergistic effects of cyclic tension and transforming growth factor-beta1 on the aortic valve myofibroblast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Calcific aortic stenosis: a disease ready for prime time

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

An ex vivo study of the biological properties of porcine aortic valves in response to circumferential cyclic stretch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Pathogenesis of calcific aortic valve disease: a disease process comes of age (and a good deal more).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Differential immediate-early gene responses to elevated pressure in porcine aortic valve interstitial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

The bicuspid aortic valve

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Mutations in NOTCH1 cause aortic valve disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Heart valve development: endothelial cell signaling and differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Expression and activity of matrix metalloproteinase-2 in calcific aortic stenosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

The congenitally bicuspid aortic valve: how does it function? Why does it fail?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Human Aortic Valve Calcification Is Associated With an Osteoblast Phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

The cardiac valve interstitial cell

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Transforming growth factor-beta1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Clinical significance of the bicuspid aortic valve

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Estimation of the shear stress on the surface of an aortic valve leaflet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Progression of aortic valve dysfunction in 51 adult patients with congenital bicuspid aortic valve: assessment and follow up by Doppler echocardiography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Accumulation of T lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Osteocalcin. Biochemical considerations and clinical applications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

The natural history of a non-stenotic bicuspid aortic valve

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Two-Dimensional Echocardiographic Features of Bicuspid Aortic Valve

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

21 June 2018

Role of human valve interstitial cells in valve calcification and their response to atorvastatin.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048843

21 January 2018

Transforming growth factor-beta1 mechanisms in aortic valve calcification: increased alkaline phosphatase and related events.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048843

21 January 2018

Age-associated aortic stenosis in apolipoprotein E-deficient mice.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048843

21 January 2018

Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048843

21 January 2018

Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048843

21 January 2018

Increased expression of elastolytic cathepsins S, K, and V and their inhibitor cystatin C in stenotic aortic valves.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048843

21 January 2018

Images in cardiovascular medicine. Evaluation of bicuspid aortic valve and aortic coarctation with 4D flow magnetic resonance imaging

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048843

21 January 2018

Cyclic pressure affects the biological properties of porcine aortic valve leaflets in a magnitude and frequency dependent manner.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048843

21 January 2018

Effects of constant static pressure on the biological properties of porcine aortic valve leaflets

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048843

21 January 2018

Valvular endothelial cells regulate the phenotype of interstitial cells in co-culture: effects of steady shear stress.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048843

21 January 2018

Cyclic pressure and shear stress regulate matrix metalloproteinases and cathepsin activity in porcine aortic valves.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

25 November 2018

Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

25 November 2018

Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485349

25 November 2018

The Bicuspid Aortic Valve

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048843

21 January 2018

The congenitally bicuspid aortic valve. A study of 85 autopsy cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Echocardiographic Recognition of the Congenital Bicuspid Aortic Valve

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Computational assessment of bicuspid aortic valve wall-shear stress: implications for calcific aortic valve disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone formation and inflammation in cardiac valves

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of endothelial cell adhesion molecules on heart valves: up-regulation in degeneration as well as acute endocarditis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A classification system for the bicuspid aortic valve from 304 surgical specimens

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of MMP2, MMP9, MT1-MMP, TIMP1, and TIMP2 mRNA in valvular lesions of the heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor alpha promotes an osteoblast-like phenotype in human aortic valve myofibroblasts: a potential regulatory mechanism of valvular calcification

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequency by decades of unicuspid, bicuspid, and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated aortic regurgitation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Congenitally bicuspid aortic valves: a surgical pathology study of 542 cases (1991 through 1996) and a literature review of 2,715 additional cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aortic stenosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic strain inhibits acute pro-inflammatory gene expression in aortic valve interstitial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteopontin is expressed in human aortic valvular lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro characterization of bicuspid aortic valve hemodynamics using particle image velocimetry

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular matrix remodelling in human aortic valve disease: the role of matrix metalloproteinases and their tissue inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of osteopontin in calcified human aortic valves

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for an altered balance between matrix metalloproteinase-9 and its inhibitors in calcific aortic stenosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix metalloproteinase expression in nonrheumatic aortic stenosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23119099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0048843

1 reference

Europe PubMed Central

PMC publication ID

4 October 2017

2012PLoSO...748843S

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

4 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

4 October 2017

ResearchGate publication ID

0 references

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