(Q31122335)

29 June 2017

Biophysical properties of human antibody variable domains (English)

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29 June 2017

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Annemarie Honegger

3

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Andreas Plückthun

object named as

Andreas Plückthun

series ordinal

4

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author name string

Stefan Ewert

series ordinal

1

1 reference

PubMed ID

12498801

29 June 2017

Thomas Huber

series ordinal

2

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PubMed ID

12498801

29 June 2017

language of work or name

English

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publication date

1 January 2003

1 reference

Journal of Molecular Biology

29 June 2017

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29 June 2017

325

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29 June 2017

531-553

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29 June 2017

3

1 reference

Recombinant antibody fragments

29 June 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Exploiting antibody-based technologies to manage environmental pollution

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Single-chain antigen-binding proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

A comparison of strategies to stabilize immunoglobulin Fv-fragments

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Engineered turns of a recombinant antibody improve its in vivo folding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Identification of framework residues in a secreted recombinant antibody fragment that control production level and localization in Escherichia coli.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Two amino acid mutations in an anti-human CD3 single chain Fv antibody fragment that affect the yield on bacterial secretion but not the affinity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Disrupting the hydrophobic patches at the antibody variable/constant domain interface: improved in vivo folding and physical characterization of an engineered scFv fragment.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Stability engineering of antibody single-chain Fv fragments

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Different Equilibrium Stability Behavior of ScFv Fragments: Identification, Classification, and Improvement by Protein Engineering†

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Domain interactions in antibody Fv and scFv fragments: effects on unfolding kinetics and equilibria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

The scFv fragment of the antibody hu4D5-8: evidence for early premature domain interaction in refolding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Picomolar affinity antibodies from a fully synthetic naive library selected and evolved by ribosome display

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Intrabody construction and expression III: engineering hyperstable V(H) domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Folding and assembly of an antibody Fv fragment, a heterodimer stabilized by antigen 1 1Edited by P. E. Wright

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Intrabody construction and expression. I. The critical role of VL domain stability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Four structural risk factors identify most fibril-forming kappa light chains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Yet Another Numbering Scheme for Immunoglobulin Variable Domains: An Automatic Modeling and Analysis Tool

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Humanization of an anti-p185HER2 antibody for human cancer therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Biophysical Properties of Camelid VHHDomains Compared to Those of Human VH3 Domains†

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

High-level temperature-induced synthesis of an antibody VH-domain in Escherichia coli using the PelB secretion signal.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Denaturant m values and heat capacity changes: relation to changes in accessible surface areas of protein unfolding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Physicochemical consequences of amino acid variations that contribute to fibril formation by immunoglobulin light chains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

The influence of the buried glutamine or glutamate residue in position 6 on the structure of immunoglobulin variable domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Roles of electrostatic interaction in proteins.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Measuring and increasing protein stability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

MOLMOL: a program for display and analysis of macromolecular structures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Structural patterns at residue positions 9, 18, 67 and 82 in the VH framework regions of human and murine immunoglobulins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

The importance of framework residues H6, H7 and H10 in antibody heavy chains: experimental evidence for a new structural subclassification of antibody V(H) domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Protein aggregation: folding aggregates, inclusion bodies and amyloid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Selection for improved protein stability by phage display.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Sequence analysis and bacterial production of the anti-c-myc antibody 9E10: the V(H) domain has an extended CDR-H3 and exhibits unusual solubility

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Comparison of physical chemical properties of llama VHH antibody fragments and mouse monoclonal antibodies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

A single-domain antibody fragment in complex with RNase A: non-canonical loop structures and nanomolar affinity using two CDR loops

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Isolation of high affinity human antibodies directly from large synthetic repertoires.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

The disulfide bonds in antibody variable domains: effects on stability, folding in vitro, and functional expression in Escherichia coli.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Correlation betweenin VitroStability andin VivoPerformance of Anti-GCN4 Intrabodies as Cytoplasmic Inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

The intracellular antibody capture technology (IACT): towards a consensus sequence for intracellular antibodies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Intracellular antibody capture technology: application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Recombining germline-derived CDR sequences for creating diverse single-framework antibody libraries

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Design and use of a phage display library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

By-passing selection: direct screening for antibody-antigen interactions using protein arrays

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Selection for a periplasmic factor improving phage display and functional periplasmic expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Multicopy suppressors of prc mutant Escherichia coli include two HtrA (DegP) protease homologs (HhoAB), DksA, and a truncated R1pA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Renaturation, purification and characterization of recombinant Fab-fragments produced in Escherichia coli

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Specific detection of his-tagged proteins with recombinant anti-His tag scFv-phosphatase or scFv-phage fusions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

Synthesis, physicochemical characterization, and crystallization of a putative retro-coiled coil

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901237-8

10.1016/S0022-2836(02)01237-8

7 January 2021

Identifiers

DOI

1 reference

29 June 2017

1 reference

PubMed ID

12498801