(Q31133166)

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Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast: identification of second-site mutations that restore function to a coupling-deficient mutant M3 receptor.

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5 January 2020

Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast: identification of second-site mutations that restore function to a coupling-deficient mutant M3 receptor (English)

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15572356%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Kenneth A. Jacobson

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5 January 2020

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Bo Li

1

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5 January 2020

Nicola M Nowak

2

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5 January 2020

Soo-Kyung Kim

3

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5 January 2020

Ali Bagheri

5

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5 January 2020

Clarice Schmidt

6

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5 January 2020

Jürgen Wess

7

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5 January 2020

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30 November 2004

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5 January 2020

Journal of Biological Chemistry

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5 January 2020

280

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5 January 2020

5664-5675

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5 January 2020

7

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5 January 2020

Initial sequencing and analysis of the human genome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

The Sequence of the Human Genome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Identification of G protein-coupled receptor genes from the human genome sequence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Seven-transmembrane receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Molecular tinkering of G protein-coupled receptors: an evolutionary success

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Crystal structure of rhodopsin: A G protein-coupled receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Structure of bovine rhodopsin in a trigonal crystal form.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Molecular biology of muscarinic acetylcholine receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Functional expression of M(1), M(3) and M(5) muscarinic acetylcholine receptors in yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast. Identification of point mutations that "silence" a constitutively active mutant M3 receptor and greatly impair receptor/G protein coupling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Single amino acid substitutions and deletions that alter the G protein coupling properties of the V2 vasopressin receptor identified in yeast by receptor random mutagenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Genetic mapping of the human C5a receptor. Identification of transmembrane amino acids critical for receptor function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

C5a receptor activation. Genetic identification of critical residues in four transmembrane helices

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Mutation of Pro-258 in transmembrane domain 6 constitutively activates the G protein-coupled alpha-factor receptor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

The third cytoplasmic loop of a yeast G-protein-coupled receptor controls pathway activation, ligand discrimination, and receptor internalization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Reciprocal mutations of highly conserved residues in transmembrane helices 2 and 7 of the alpha(2A)-adrenoceptor restore agonist activation of G(i1)alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

The role of conserved aspartate and serine residues in ligand binding and in function of the 5-HT1A receptor: a site-directed mutation study

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Mutation of Asp74 of the rat angiotensin II receptor confers changes in antagonist affinities and abolishes G-protein coupling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Aspartate mutation distinguishes ETA but not ETB receptor subtype-selective ligand binding while abolishing phospholipase C activation in both receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Binding of low affinity N-formyl peptide receptors to G protein. Characterization of a novel inactive receptor intermediate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

The Lutropin/Choriogonadotropin Receptor, A 2002 Perspective

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Plasma membrane localization and functional rescue of truncated forms of a G protein-coupled receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Functional role of the third cytoplasmic loop in muscarinic receptor dimerization.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Recombination-mediated PCR-directed plasmid construction in vivo in yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Fourier transform infrared difference spectroscopy of rhodopsin mutants: light activation of rhodopsin causes hydrogen-bonding change in residue aspartic acid-83 during meta II formation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Seven-transmembrane receptors: crystals clarify

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Rhodopsin mutants that bind but fail to activate transducin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

The function of a highly-conserved arginine residue in activation of the muscarinic M1 receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Three-dimensional model for meta-II rhodopsin, an activated G-protein-coupled receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

The ants go marching two by two: oligomeric structure of G-protein-coupled receptors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Identification and molecular characterization of m3 muscarinic receptor dimers.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

C5a receptor oligomerization. I. Disulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Multiple interactions between transmembrane helices generate the oligomeric alpha1b-adrenoceptor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Identification of a family of muscarinic acetylcholine receptor genes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411623200

21 January 2018

Identifiers

10.1074/JBC.M411623200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15572356%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15572356%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

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