(Q42524236)

English

Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations.

scientific article published on 26 July 2002

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scholarly article

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11 November 2019

Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations (English)

1 reference

Europe PubMed Central

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11 November 2019

Harel Weinstein

4

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11 November 2019

author name string

Cassandra Prioleau

1

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11 November 2019

Irache Visiers

2

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11 November 2019

Barbara J Ebersole

3

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11 November 2019

Stuart C Sealfon

5

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11 November 2019

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publication date

26 July 2002

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11 November 2019

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8

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Journal of Biological Chemistry

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11 November 2019

277

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11 November 2019

36577-36584

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11 November 2019

39

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11 November 2019

Initial sequencing and analysis of the human genome

1 reference

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21 January 2018

The Sequence of the Human Genome

1 reference

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Seven-transmembrane receptors: crystals clarify

1 reference

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Sequence alignment of the G-protein coupled receptor superfamily

1 reference

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Crystal structure of rhodopsin: A G protein-coupled receptor

1 reference

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Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)

1 reference

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Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F.

1 reference

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21 January 2018

Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor

1 reference

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21 January 2018

Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor

1 reference

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21 January 2018

Conformational changes that occur during M3 muscarinic acetylcholine receptor activation probed by the use of an in situ disulfide cross-linking strategy

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21 January 2018

Activation of rhodopsin: new insights from structural and biochemical studies

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21 January 2018

Insertional mutagenesis of the arginine cage domain of the gonadotropin-releasing hormone receptor

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21 January 2018

Transmembrane domains 4 and 7 of the M(1) muscarinic acetylcholine receptor are critical for ligand binding and the receptor activation switch

1 reference

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21 January 2018

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

1 reference

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21 January 2018

Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp.

1 reference

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21 January 2018

Constitutive activation of the mu opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression.

1 reference

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21 January 2018

The second intracellular loop of the m5 muscarinic receptor is the switch which enables G-protein coupling

1 reference

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21 January 2018

Mechanism of constitutive activation of the AT1 receptor: influence of the size of the agonist switch binding residue Asn(111).

1 reference

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21 January 2018

Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation

1 reference

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21 January 2018

An activation switch in the ligand binding pocket of the C5a receptor

1 reference

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21 January 2018

Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6.

1 reference

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21 January 2018

Phe(303) in TMVI of the alpha(1B)-adrenergic receptor is a key residue coupling TM helical movements to G-protein activation

1 reference

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21 January 2018

Two different forms of metarhodopsin II: Schiff base deprotonation precedes proton uptake and signaling state

1 reference

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21 January 2018

Conformation and stability of alpha-helical membrane proteins. 1. Influence of salts on conformational equilibria between active and Inactive states of rhodopsin

1 reference

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21 January 2018

Single-molecule spectroscopy of the beta(2) adrenergic receptor: observation of conformational substates in a membrane protein

1 reference

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21 January 2018

Agonist-receptor efficacy. II. Agonist trafficking of receptor signals

1 reference

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21 January 2018

Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus.

1 reference

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21 January 2018

Agonist regulation of D(2) dopamine receptor/G protein interaction. Evidence for agonist selection of G protein subtype

1 reference

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21 January 2018

Control of conformational equilibria in the human B2 bradykinin receptor. Modeling of nonpeptidic ligand action and comparison to the rhodopsin structure.

1 reference

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21 January 2018

Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor

1 reference

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21 January 2018

Conversion of agonist site to metal-ion chelator site in the beta(2)-adrenergic receptor

1 reference

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21 January 2018

A proposed structure for transmembrane segment 7 of G protein-coupled receptors incorporating an asn-Pro/Asp-Pro motif

1 reference

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21 January 2018

Conserved helix 7 tyrosine functions as an activation relay in the serotonin 5HT(2C) receptor

1 reference

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21 January 2018

Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes

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21 January 2018

Analyzing mRNA-protein complexes using a yeast three-hybrid system

1 reference

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21 January 2018

Protein engineering and the study of structure--function relationships in receptors

1 reference

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21 January 2018

Differences in agonist-independent activity of 5-Ht2A and 5-HT2c receptors revealed by heterologous expression

1 reference

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21 January 2018

Mutations of Tyr326 in the beta 2-adrenoceptor disrupt multiple receptor functions.

1 reference

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21 January 2018

Identification of potential tyrosine-containing endocytic motifs in the carboxyl-tail and seventh transmembrane domain of the neurokinin 1 receptor

1 reference

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The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization.

1 reference

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21 January 2018

Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor

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The propagation of binding interactions to remote sites in proteins: analysis of the binding of the monoclonal antibody D1.3 to lysozyme

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A Conserved NPLFY Sequence Contributes to Agonist Binding and Signal Transduction but Is Not an Internalization Signal for the Type 1 Angiotensin II Receptor

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Functional Microdomains in G-protein-coupled Receptors

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Identifiers

10.1074/JBC.M206223200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12145300%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

release_v3xfbsqhffdbtofzlfvixovh7a

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https://api.fatcat.wiki/v0/release/v3xfbsqhffdbtofzlfvixovh7a

24 November 2022

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Europe PubMed Central

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11 November 2019

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