(Q31135534)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

title

CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Timothy P. Hickling

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

author name string

Brian J Fennell

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Barry McDonnell

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Amy Sze Pui Tam

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Lijun Chang

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

John Steven

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Huilan Gao

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Elizabeth Kieras

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Jennifer Alley

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Deborah Luxenberg

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Jason Edmonds

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Lori J Fitz

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Wenyan Miao

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Matthew J Whitters

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Quintus G Medley

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Yongjing J Guo

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Alfredo Darmanin-Sheehan

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Bénédicte Autin

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Deirdre Ní Shúilleabháin

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Emma Cummins

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Amy King

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Mark R H Krebs

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Christopher Grace

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Angela Boisvert

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Xiaotian Zhong

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Matthew McKenna

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Christopher Francis

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Stephane Olland

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Laird Bloom

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Janet Paulsen

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Will Somers

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Allan Jensen

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Laura Lin

34

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

William J J Finlay

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Orla Cunningham

36

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

publication date

21 August 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

published in

Monoclonal Antibodies

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

page(s)

882-895

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

Comprehensive interrogation of a minimalist synthetic CDR-H3 library and its ability to generate antibodies with therapeutic potential

8 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

Rapid optimization and prototyping for therapeutic antibody-like molecules

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

High-throughput measurement, correlation analysis, and machine-learning predictions for pH and thermal stabilities of Pfizer-generated antibodies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

Optimized generation of high-affinity, high-specificity single-chain Fv antibodies from multiantigen immunized chickens

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

Stability engineering of scFvs for the development of bispecific and multivalent antibodies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

Therapeutic antibodies for autoimmunity and inflammation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

Computational analysis of off-rate selection experiments to optimize affinity maturation by directed evolution

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

A dual-targeting PDGFRbeta/VEGF-A molecule assembled from stable antibody fragments demonstrates anti-angiogenic activity in vitro and in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTbetaR.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

Engineering of stable bispecific antibodies targeting IL-17A and IL-23.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

A modular IgG-scFv bispecific antibody topology

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

Catumaxomab: a bispecific trifunctional antibody.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

Affinity maturation of a humanized rat antibody for anti-RAGE therapy: comprehensive mutagenesis reveals a high level of mutational plasticity both inside and outside the complementarity-determining regions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

Improving antibody binding affinity and specificity for therapeutic development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

Tumor regression in cancer patients by very low doses of a T cell-engaging antibody

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

Treatment of non-small cell lung cancer patients with the trifunctional monoclonal antibody catumaxomab (anti-EpCAM x anti-CD3): a phase I study

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

Methods for the generation of chicken monoclonal antibody fragments by phage display

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

Influence of mass transfer and surface ligand heterogeneity on quantitative BIAcore binding data. Analysis of the interaction of NC10 Fab with an anti-idiotype Fab'.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

Antibody fragments from a 'single pot' phage display library as immunochemical reagents

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896602

Treatment of malignant pleural effusion with the trifunctional antibody catumaxomab (Removab) (anti-EpCAM x Anti-CD3): results of a phase 1/2 study.

21 June 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.26201

Domain interactions in the Fab fragment: a comparative evaluation of the single-chain Fv and Fab format engineered with variable domains of different stability

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.26201

High-throughput dynamic light scattering method for measuring viscosity of concentrated protein solutions

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.26201

A simple high-throughput purification method for hit identification in protein screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.26201

Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.26201

Improving biosensor analysis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23995618

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Aggregation-resistant domain antibodies selected on phage by heat denaturation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23995618

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pharmacokinetics of heterologous and homologous immunoglobulin G, F(ab')2 and Fab after intravenous administration in the rat

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23995618

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4161/MABS.26201

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995618%20AND%20SRC:MED&resulttype=core&format=json