(Q37736260)

22 August 2017

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title

Therapeutic antibodies for autoimmunity and inflammation (English)

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22 August 2017

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Andrew C Chan

1

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22 August 2017

Paul J Carter

series ordinal

2

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22 August 2017

publication date

1 May 2010

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Nature Reviews Immunology

22 August 2017

published in

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22 August 2017

volume

10

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22 August 2017

issue

5

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22 August 2017

page(s)

301-316

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mAbs: a business perspective

22 August 2017

cites work

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Industrialization of mAb production technology: the bioprocessing industry at a crossroads

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Engineered therapeutic antibodies with improved effector functions

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31 March 2020

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Anti-infliximab IgE and non-IgE antibodies and induction of infusion-related severe anaphylactic reactions.

31 March 2020

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Formation of antibodies against infliximab and adalimumab strongly correlates with functional drug levels and clinical responses in rheumatoid arthritis

31 March 2020

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Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial

31 March 2020

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Clinical response to adalimumab: relationship to anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis

31 March 2020

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Golimumab, a human anti-tumor necrosis factor α monoclonal antibody, injected subcutaneously every four weeks in methotrexate-naive patients with active rheumatoid arthritis: Twenty-four-week results of a phase III, multicenter, randomized, double-b

31 March 2020

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Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway

31 March 2020

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Chimeric anti-TNF-alpha monoclonal antibody cA2 binds recombinant transmembrane TNF-alpha and activates immune effector functions

31 March 2020

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Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease

31 March 2020

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Certolizumab pegol for the treatment of Crohn's disease

31 March 2020

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Maintenance therapy with certolizumab pegol for Crohn's disease

31 March 2020

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Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra

31 March 2020

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In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes

31 March 2020

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Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

31 March 2020

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Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)

31 March 2020

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A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease

31 March 2020

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Blockade of CD11a by Efalizumab in Psoriasis Patients Induces a Unique State of T-Cell Hyporesponsiveness

31 March 2020

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The effect of treatment with omalizumab, an anti-IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthma

31 March 2020

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Omalizumab-induced reductions in mast cell Fce psilon RI expression and function

31 March 2020

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Omalizumab treatment downregulates dendritic cell FcepsilonRI expression

31 March 2020

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Endocytosis, recycling, and degradation of unoccupied FcepsilonRI in human basophils

31 March 2020

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Basophil phenotypes in chronic idiopathic urticaria in relation to disease activity and autoantibodies

31 March 2020

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Comparative studies of functional and binding assays for IgG anti-Fc(epsilon)RIalpha (alpha-subunit) in chronic urticaria.

31 March 2020

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Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks

31 March 2020

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B-cell depletion with rituximab in relapsing-remitting multiple sclerosis

31 March 2020

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Alemtuzumab vs. interferon beta-1a in early multiple sclerosis

31 March 2020

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Ocrelizumab, a humanized anti-CD20 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I/II randomized, blinded, placebo-controlled, dose-ranging study.

31 March 2020

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Differential effects of epratuzumab on peripheral blood B cells of patients with systemic lupus erythematosus versus normal controls

31 March 2020

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CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: further regulation by CD55 and CD59

31 March 2020

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Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy

31 March 2020

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Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI, FcgammaRIII, and FcgammaRIV.

31 March 2020

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Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene

31 March 2020

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Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma

31 March 2020

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The relationship of FcgammaRIIIa genotype to degree of B cell depletion by rituximab in the treatment of systemic lupus erythematosus.

31 March 2020

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Diffuse large B-cell lymphoma: reduced CD20 expression is associated with an inferior survival

31 March 2020

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A quantitative exploration of surface antigen expression in common B-cell malignancies using flow cytometry.

31 March 2020

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Complement-induced cell death by rituximab depends on CD20 expression level and acts complementary to antibody-dependent cellular cytotoxicity

31 March 2020

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Complement activation determines the therapeutic activity of rituximab in vivo.

31 March 2020

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Expression of complement inhibitors CD46, CD55, and CD59 on tumor cells does not predict clinical outcome after rituximab treatment in follicular non-Hodgkin lymphoma

31 March 2020

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Assessment of rituximab's immunomodulatory synovial effects (ARISE trial). 1: clinical and synovial biomarker results

31 March 2020

1 reference

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

31 March 2020

1 reference

Ten years of Orthoclone OKT3 (muromonab-CD3): a review

31 March 2020

1 reference

Anti-CD3 antibodies: towards clinical antigen-specific immunomodulation

31 March 2020

1 reference

Pharmacokinetics and pharmacodynamics of a chimeric/humanized anti-CD3 monoclonal antibody, otelixizumab (TRX4), in subjects with psoriasis and with type 1 diabetes mellitus

31 March 2020

1 reference

Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala).

31 March 2020

1 reference

TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs

31 March 2020

1 reference

Development trends for therapeutic antibody fragments

31 March 2020

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When binding is enough: nonactivating antibody formats.

31 March 2020

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Phase I trial of a humanized, Fc receptor nonbinding OKT3 antibody, huOKT3gamma1(Ala-Ala) in the treatment of acute renal allograft rejection

31 March 2020

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The generation of a humanized, non-mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties

31 March 2020

1 reference

Isotype selection in antibody engineering

31 March 2020

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Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

31 March 2020

1 reference

Antibody therapeutics: isotype and glycoform selection

31 March 2020

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Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses.

31 March 2020

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Elimination of Fc receptor-dependent effector functions of a modified IgG4 monoclonal antibody to human CD4.

31 March 2020

1 reference

Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria

31 March 2020

1 reference

Efficacy of a novel PEGylated humanized anti-TNF fragment (CDP870) in patients with rheumatoid arthritis: a phase II double-blinded, randomized, dose-escalating trial

31 March 2020

1 reference

Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas

31 March 2020

1 reference

High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

31 March 2020

1 reference

Enhancing the potency of therapeutic monoclonal antibodies via Fc optimization

31 March 2020

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Engineered antibody Fc variants with enhanced effector function

31 March 2020

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Optimization of antibody binding to FcgammaRIIa enhances macrophage phagocytosis of tumor cells

31 March 2020

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Aglycosylated IgG variants expressed in bacteria that selectively bind FcgammaRI potentiate tumor cell killing by monocyte-dendritic cells

31 March 2020

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Glycosylation as a strategy to improve antibody-based therapeutics

31 March 2020

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Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity

31 March 2020

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Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity

31 March 2020

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The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity

31 March 2020

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Establishment of FUT8 knockout Chinese hamster ovary cells: an ideal host cell line for producing completely defucosylated antibodies with enhanced antibody-dependent cellular cytotoxicity

31 March 2020

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Nonfucosylated therapeutic IgG1 antibody can evade the inhibitory effect of serum immunoglobulin G on antibody-dependent cellular cytotoxicity through its high binding to FcgammaRIIIa.

31 March 2020

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Optimization of humanized IgGs in glycoengineered Pichia pastoris.

31 March 2020

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Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc

31 March 2020

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Engineered antibodies with increased activity to recruit complement

31 March 2020

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Modulation of the effector functions of a human IgG1 through engineering of its hinge region

31 March 2020

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Engineered antibodies of IgG1/IgG3 mixed isotype with enhanced cytotoxic activities

31 March 2020

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Depletion of B cells by a humanized anti-CD20 antibody PRO70769 in Macaca fascicularis

31 March 2020

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Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity

31 March 2020

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Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation

31 March 2020

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Antibody pharmacokinetics and pharmacodynamics

31 March 2020

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FcRn: the neonatal Fc receptor comes of age.

31 March 2020

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Metabolic properties of IgG subclasses in man

31 March 2020

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Increasing the serum persistence of an IgG fragment by random mutagenesis.

31 March 2020

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Engineered human IgG antibodies with longer serum half-lives in primates

31 March 2020

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An engineered human IgG1 antibody with longer serum half-life.

31 March 2020

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Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor

31 March 2020

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Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn).

31 March 2020

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Structural characterization of a human Fc fragment engineered for extended serum half-life

31 March 2020

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Enhanced antibody half-life improves in vivo activity

31 March 2020

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Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies

31 March 2020

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Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.

31 March 2020

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Increasing the affinity of a human IgG1 for the neonatal Fc receptor: biological consequences.

31 March 2020

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Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels.

31 March 2020

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Therapeutic antibody fragments with prolonged in vivo half-lives

31 March 2020

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The impact of PEGylation on biological therapies

31 March 2020

1 reference

Design of yeast-secreted albumin derivatives for human therapy: biological and antiviral properties of a serum albumin-CD4 genetic conjugate

31 March 2020

1 reference

Designing CD4 immunoadhesins for AIDS therapy

31 March 2020

1 reference

A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner

31 March 2020

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Albumin binding as a general strategy for improving the pharmacokinetics of proteins

31 March 2020

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Retargeting serum immunoglobulin with bispecific diabodies

31 March 2020

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Enhancement of therapeutic protein in vivo activities through glycoengineering

31 March 2020

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Antibody-drug conjugates for cancer therapy

31 March 2020

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Bispecific T-cell engaging antibodies for cancer therapy

31 March 2020

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Recombinant approaches to IgG-like bispecific antibodies

31 March 2020

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Quantitative Estimation of the Hybridization of Rabbit Antibodies

31 March 2020

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Recombinant bispecific antibodies for cancer therapy

31 March 2020

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Hybrid antibodies can target sites for attack by T cells

31 March 2020

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Tumor regression in cancer patients by very low doses of a T cell-engaging antibody

31 March 2020

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A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity.

31 March 2020

1 reference

Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody.

31 March 2020

1 reference

Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site

31 March 2020

1 reference

Treatment with a novel poly(ADP-ribose) glycohydrolase inhibitor reduces development of septic shock-like syndrome induced by zymosan in mice

31 March 2020

1 reference

Selective costimulation modulation using abatacept in patients with active rheumatoid arthritis while receiving etanercept: a randomised clinical trial

31 March 2020

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IL-1, IL-18, and IL-33 families of cytokines

31 March 2020

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Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment

31 March 2020

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Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1Ra

31 March 2020

1 reference

Molecular construction and optimization of anti-human IL-1alpha/beta dual variable domain immunoglobulin (DVD-Ig) molecules

31 March 2020

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Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin.

31 March 2020

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Development and function of TH17 cells in health and disease

31 March 2020

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Engineering of stable bispecific antibodies targeting IL-17A and IL-23.

31 March 2020

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Mitogenic properties of a bispecific single-chain Fv-Ig fusion generated from CD2-specific mAb to distinct epitopes

31 March 2020

1 reference

Intradiabodies, bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors.

31 March 2020

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Design and production of novel tetravalent bispecific antibodies

31 March 2020

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Engineering bispecific antibodies

31 March 2020

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Rituximab levels in cerebrospinal fluid of patients with neurological autoimmune disorders.

31 March 2020

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Single-chain antigen-binding proteins

31 March 2020

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Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli

31 March 2020

1 reference

"Diabodies": small bivalent and bispecific antibody fragments

31 March 2020

1 reference

Single-domain antibodies as building blocks for novel therapeutics

31 March 2020

1 reference

Hybrid hybridomas and their use in immunohistochemistry

31 March 2020

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Bispecific monoclonal antibodies from hybrid hybridomas

31 March 2020

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An efficient route to human bispecific IgG.

31 March 2020

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Antibody engineering to develop new antirheumatic therapies

31 March 2020

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Structural characterization of a human Fc fragment engineered for lack of effector functions

31 March 2020

1 reference

Monoclonal antibodies: versatile platforms for cancer immunotherapy

31 March 2020

1 reference

Bispecific antibodies for cancer therapy

31 March 2020

1 reference

12 December 2020

Consensus statement regarding OKT3-induced cytokine-release syndrome and human antimouse antibodies.

1 reference

12 December 2020

Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments.

1 reference

12 December 2020

Decreased CD20 expression in rheumatoid arthritis synovium following 8 weeks of rituximab therapy

1 reference

12 December 2020

Abatacept binds to the Fc receptor CD64 but does not mediate complement-dependent cytotoxicity or antibody-dependent cellular cytotoxicity

1 reference

12 December 2020

Complete inhibition of vascular endothelial growth factor (VEGF) activities with a bifunctional diabody directed against both VEGF kinase receptors, fms-like tyrosine kinase receptor and kinase insert domain-containing receptor

1 reference

12 December 2020

Down-regulation of Fc(epsilon)RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody.

1 reference

12 December 2020

A non-activating "humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo

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12 December 2020

Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells

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12 December 2020

Humanization of antibodies.

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12 December 2020

Engineered anti-CD20 antibodies with enhanced complement-activating capacity mediate potent anti-lymphoma activity

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRI2761

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22 August 2017

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