(Q35214746)

7 August 2017

title

Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies (English)

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7 August 2017

1 reference

4

Raimund J Ober

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7 August 2017

5

E Sally Ward

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7 August 2017

Carlos Vaccaro

1

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7 August 2017

Roger Bawdon

series ordinal

2

1 reference

7 August 2017

Sylvia Wanjie

series ordinal

3

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7 August 2017

language of work or name

English

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publication date

20 November 2006

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7 August 2017

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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7 August 2017

volume

103

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7 August 2017

issue

49

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7 August 2017

page(s)

18709-18714

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Potent antibody therapeutics by design

7 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

Engineered antibody Fc variants with enhanced effector function

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

Engineered human IgG antibodies with longer serum half-lives in primates

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

Immunoglobulin transport across polarized epithelial cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

Increasing the affinity of a human IgG1 for the neonatal Fc receptor: biological consequences.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

beta(2)-Microglobulin is important for cell surface expression and pH-dependent IgG binding of human FcRn.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

13 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

Expression of functionally active FcRn and the differentiated bidirectional transport of IgG in human placental endothelial cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

Multiple roles for the major histocompatibility complex class I- related receptor FcRn

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

Characterization and localization of the neonatal Fc receptor in adult human kidney

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

Increasing the serum persistence of an IgG fragment by random mutagenesis.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

Effect of glycosylation on antibody function: implications for genetic engineering

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

The stoichiometry and affinity of the interaction of murine Fc fragments with the MHC class I-related receptor, FcRn

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

Mouse MHC class I-like Fc receptor encoded outside the MHC.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

pH-dependent binding of immunoglobulins to intestinal cells of the neonatal rat

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693727

High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

13 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606304103

Functional expression of the MHC class I-related receptor, FcRn, in endothelial cells of mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606304103

Analysis of the pH dependence of the neonatal Fc receptor/immunoglobulin G interaction using antibody and receptor variants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606304103

An engineered human IgG1 antibody with longer serum half-life.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606304103

Studies on the immunoglobulin-G Fc-fragment receptor from neonatal rat small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606304103

Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606304103

Upping the ante on antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606304103

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606304103

Compensation for loss of ligand activity in surface plasmon resonance experiments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606304103

Identifying amino acid residues that influence plasma clearance of murine IgG1 fragments by site-directed mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606304103

Localization of the site of the murine IgG1 molecule that is involved in binding to the murine intestinal Fc receptor

21 January 2018

1 reference

12 December 2020

Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans

1 reference

12 December 2020

The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs

1 reference

12 December 2020

Antibody framework residues affecting the conformation of the hypervariable loops

1 reference

12 December 2020

Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice

1 reference

12 December 2020

Increased clearance of IgG in mice that lack beta 2-microglobulin: possible protective role of FcRn

1 reference

12 December 2020

Delineation of the amino acid residues involved in transcytosis and catabolism of mouse IgG1

1 reference

12 December 2020

Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells

1 reference

12 December 2020

Mapping the site on human IgG for binding of the MHC class I-related receptor, FcRn

1 reference

12 December 2020

Conferring the binding properties of the mouse MHC class I-related receptor, FcRn, onto the human ortholog by sequential rounds of site-directed mutagenesis

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0606304103

1 reference

7 August 2017

0 references

1 reference

7 August 2017

1 reference