(Q31141055)

29 June 2017

title

Pharmacokinetics and biodistribution of novel aptamer compositions (English)

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29 June 2017

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Judith M Healy

1

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29 June 2017

Scott D Lewis

2

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29 June 2017

Markus Kurz

3

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29 June 2017

Ryan M Boomer

4

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29 June 2017

Kristin M Thompson

5

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29 June 2017

Charles Wilson

6

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29 June 2017

Thomas G McCauley

7

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29 June 2017

publication date

1 December 2004

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29 June 2017

published in

Pharmaceutical Research

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29 June 2017

volume

21

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29 June 2017

issue

12

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29 June 2017

page(s)

2234-2246

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In vivo properties of an anti-GnRH Spiegelmer: an example of an oligonucleotide-based therapeutic substance class

29 June 2017

cites work

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Pharmacokinetics and biodistribution of a nucleotide-based thrombin inhibitor in rats

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A 16-mer peptide (RQIKIWFQNRRMKWKK) from antennapedia preferentially targets the Class I pathway.

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Potent 2'-amino-2'-deoxypyrimidine RNA inhibitors of basic fibroblast growth factor

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Cellular delivery of antisense oligonucleotides

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12 December 2020

In vivo studies with antisense oligonucleotides

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Pharmacokinetics of oligonucleotides

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Anti-L-selectin aptamers: binding characteristics, pharmacokinetic parameters, and activity against an intravascular target in vivo

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Evolution of a T7 RNA polymerase variant that transcribes 2'-O-methyl RNA.

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Pharmacokinetic properties of 2'-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats

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Neutralization of Infectivity of Diverse R5 Clinical Isolates of Human Immunodeficiency Virus Type 1 by gp120-Binding 2′F-RNA Aptamers

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The discovery and characterization of a novel nucleotide-based thrombin inhibitor

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Controlled delivery of the anti-VEGF aptamer EYE001 with poly(lactic-co-glycolic)acid microspheres

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Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

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12 December 2020

Association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distribution

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12 December 2020

Tissue distribution and physiologically based pharmacokinetics of antisense phosphorothioate oligonucleotide ISIS 1082 in rat.

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12 December 2020

Quantification of 2'-fluoro-2'-deoxyuridine and 2'-fluoro-2'-deoxycytidine in DNA and RNA isolated from rats and woodchucks using LC/MS/MS.

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A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus

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Synthetic oligonucleotides: the development of antisense therapeutics

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12 December 2020

Nuclease-resistant nucleic acid ligands to vascular permeability factor/vascular endothelial growth factor

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Use of minimally modified antisense oligonucleotides for specific inhibition of gene expression

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Oligonucleotide inhibitors of P-selectin-dependent neutrophil-platelet adhesion

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Pharmacokinetics and metabolism of an oligodeoxynucleotide phosphorothioate (GEM91) in cynomolgus monkeys following intravenous infusion

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12 December 2020

Tritium labeling of antisense oligonucleotides by exchange with tritiated water

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12 December 2020

A novel, modification-dependent ATP-binding aptamer selected from an RNA library incorporating a cationic functionality

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12 December 2020

Antisense inhibition of P-glycoprotein expression using peptide-oligonucleotide conjugates

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12 December 2020

Oligonucleotide-peptide conjugates as potential antisense agents

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12 December 2020

Oligonucleotide conjugates as potential antisense drugs with improved uptake, biodistribution, targeted delivery, and mechanism of action

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12 December 2020

Inhibition of heregulin signaling by an aptamer that preferentially binds to the oligomeric form of human epidermal growth factor receptor-3.

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12 December 2020

Review of in vivo pharmacokinetics and toxicology of phosphorothioate oligonucleotides.

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12 December 2020

Advances in understanding the pharmacological properties of antisense oligonucleotides

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12 December 2020

Polymerization of 2'-fluoro- and 2'-O-methyl-dNTPs by human DNA polymerase alpha, polymerase gamma, and primase

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12 December 2020

In vivo imaging of oligonucleotides with positron emission tomography

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12 December 2020

Peptide-oligonucleotide phosphorothioate conjugates with membrane translocation and nuclear localization properties.

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12 December 2020

Oligonucleotide NX1838 inhibits VEGF165-mediated cellular responses in vitro

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12 December 2020

2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain

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12 December 2020

Arginine-rich molecular transporters for drug delivery: role of backbone spacing in cellular uptake

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12 December 2020

Detection and plasma pharmacokinetics of an anti-vascular endothelial growth factor oligonucleotide-aptamer (NX1838) in rhesus monkeys

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12 December 2020

Generation of RNA aptamers to the G-protein-coupled receptor for neurotensin, NTS-1.

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12 December 2020

Short polymers of arginine rapidly translocate into vascular cells: effects on nitric oxide synthesis

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12 December 2020

Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration

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12 December 2020

Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation

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12 December 2020

Sno storm in the nucleolus: new roles for myriad small RNPs

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12 December 2020

In vitro selection of RNA molecules that bind specific ligands

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12 December 2020

10.1007/S11095-004-7676-4

Identifiers

DOI

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29 June 2017

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