(Q45010727)

8 December 2017

title

Evolution of a T7 RNA polymerase variant that transcribes 2'-O-methyl RNA. (English)

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8 December 2017

author name string

Jijumon Chelliserrykattil

series ordinal

1

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8 December 2017

Andrew D Ellington

series ordinal

2

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8 December 2017

publication date

8 August 2004

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8 December 2017

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8 December 2017

volume

22

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8 December 2017

issue

9

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8 December 2017

page(s)

1155-1160

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https://scigraph.springernature.com/pub.10.1038/nbt1001

8 December 2017

exact match

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cites work

Nucleic-acid therapeutics: basic principles and recent applications

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Emerging clinical applications of RNA

21 January 2018

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Antisense technologies. Improvement through novel chemical modifications

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A combined in vitro/in vivo selection for polymerases with novel promoter specificities

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DNA polymerase active site is highly mutable: evolutionary consequences

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Directed evolution of polymerase function by compartmentalized self-replication

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Multiple amino acid substitutions allow DNA polymerases to synthesize RNA.

21 January 2018

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Directed evolution of novel polymerase activities: mutation of a DNA polymerase into an efficient RNA polymerase

21 January 2018

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Expanding the substrate repertoire of a DNA polymerase by directed evolution

21 January 2018

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2'-deoxycytidines carrying amino and thiol functionality: synthesis and incorporation by Vent (exo-) polymerase.

21 January 2018

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An unnatural hydrophobic base, 4-propynylpyrrole-2-carbaldehyde, as an efficient pairing partner of 9-methylimidazo[(4,5)-b]pyridine.

21 January 2018

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Enzymatic recognition of the base pair between isocytidine and isoguanosine

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PCR amplification of DNA containing non-standard base pairs by variants of reverse transcriptase from Human Immunodeficiency Virus-1

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1 reference

A Y639F/H784A T7 RNA polymerase double mutant displays superior properties for synthesizing RNAs with non-canonical NTPs

21 January 2018

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Efficient synthesis of nucleic acids heavily modified with non-canonical ribose 2'-groups using a mutantT7 RNA polymerase (RNAP).

21 January 2018

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Mechanism of ribose 2'-group discrimination by an RNA polymerase

21 January 2018

1 reference

Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase

21 January 2018

1 reference

Structural basis for substrate selection by t7 RNA polymerase.

21 January 2018

1 reference

RNA interference in mammalian cells by chemically-modified RNA.

21 January 2018

1 reference

Antisense therapy for cancer--the time of truth

21 January 2018

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Advantages of 2'-O-methyl oligoribonucleotide probes for detecting RNA targets

21 January 2018

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What affects the effect of 2'-alkoxy modifications? 1. Stabilization effect of 2'-methoxy substitutions in uniformly modified DNA oligonucleotides

21 January 2018

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21 January 2018

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Structural Determinants of Enzymic Processivity

21 January 2018

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Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead Ribozymes

21 January 2018

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7 January 2021

Expanding the genetic alphabet: non-epimerizing nucleoside with the pyDDA hydrogen-bonding pattern

1 reference

7 January 2021

An unnatural base pair for efficient incorporation of nucleotide analogs into RNAs

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7 January 2021

Roles of histidine 784 and tyrosine 639 in ribose discrimination by T7 RNA polymerase

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7 January 2021

A mutant T7 RNA polymerase as a DNA polymerase.

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7 January 2021

Template strand switching by T7 RNA polymerase

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7 January 2021

Identifiers

DOI

10.1038/NBT1001

1 reference

Dimensions Publication ID

8 December 2017

1052852369

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