(Q3162114)

tyrosine-protein kinase, non-receptor Jak2

1 reference

SH2 domain superfamily

1 reference

FERM superfamily, second domain

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

SH2 domain, protein family

1 reference

Band 4.1 domain, protein family

1 reference

Janus kinase 2, pseudokinase domain, protein family

1 reference

Janus kinase 2, catalytic domain, protein family

1 reference

JAK2, FERM domain C-lobe, protein family

1 reference

Tyrosine-protein kinase JAK2, SH2 domain, protein family

1 reference

FERM domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

signaling receptor binding

1 reference

9 May 2019

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

growth hormone receptor binding

IPI

interleukin-12 receptor binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

9 May 2019

Heme controls the regulation of protein tyrosine kinases Jak2 and Src

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

histone kinase activity (H3-Y41 specific)

1 reference

24 April 2018

JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60674&geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

14 references

9 May 2019

Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

hTid-1, a human DnaJ protein, modulates the interferon signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

PTP1B regulates leptin signal transduction in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

Mpl traffics to the cell surface through conventional and unconventional routes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

protein tyrosine kinase activity

IPI

11 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin

EXP

protein kinase binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

protein C-terminus binding

protein kinase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

type 1 angiotensin receptor binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

acetylcholine receptor binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

phosphatidylinositol 3-kinase binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

insulin receptor substrate binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

peptide hormone receptor binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

3 references

extrinsic component of cytoplasmic side of plasma membrane

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60674&geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

glutamatergic synapse

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

negative regulation of neuron apoptotic process

biological process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

intrinsic apoptotic signaling pathway in response to oxidative stress

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

adaptive immune response

1 reference

9 May 2019

negative regulation of DNA binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

tumor necrosis factor-mediated signaling pathway

1 reference

9 May 2019

IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of phosphoprotein phosphatase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

growth hormone receptor signaling pathway

1 reference

9 May 2019

Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of interleukin-1 beta production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of DNA binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

9 May 2019

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

activation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

negative regulation of cell population proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

regulation of apoptotic process

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60674&geneProductId=UniProtKB:O60674

positive regulation of cell activation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

mammary gland epithelium development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

extrinsic apoptotic signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons

response to antibiotic

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of nitric-oxide synthase biosynthetic process

response to oxidative stress

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

response to tumor necrosis factor

1 reference

9 May 2019

IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

response to interleukin-12

1 reference

9 May 2019

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of tumor necrosis factor production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

platelet-derived growth factor receptor signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of cell-substrate adhesion

1 reference

9 May 2019

Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of growth hormone receptor signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

G protein-coupled receptor signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

growth hormone receptor signaling pathway via JAK-STAT

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of inflammatory response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

immune system process

1 reference

9 May 2019

positive regulation of DNA-binding transcription factor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

negative regulation of cardiac muscle cell apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

actin filament polymerization

1 reference

9 May 2019

Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

response to lipopolysaccharide

NAS

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

regulation of inflammatory response

1 reference

9 May 2019

Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

peptidyl-tyrosine autophosphorylation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60674&geneProductId=UniProtKB:O60674

enzyme linked receptor protein signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of insulin secretion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

intracellular signal transduction

negative regulation of cell-cell adhesion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

mineralocorticoid receptor signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

negative regulation of heart contraction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of cell migration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of cytosolic calcium ion concentration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of nitric oxide biosynthetic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

response to hydroperoxide

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

regulation of interferon-gamma-mediated signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

regulation of cell population proliferation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60674&geneProductId=UniProtKB:O60674

positive regulation of cell population proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

hormone-mediated signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of phosphatidylinositol 3-kinase signaling

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60674&geneProductId=UniProtKB:O60674

peptidyl-tyrosine phosphorylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60674&geneProductId=UniProtKB:O60674

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of epithelial cell apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of growth factor dependent skeletal muscle satellite cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

negative regulation of cell death

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of vascular associated smooth muscle cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

activation of Janus kinase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

tyrosine phosphorylation of STAT protein

cytokine-mediated signaling pathway

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60674&geneProductId=UniProtKB:O60674

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60674&geneProductId=UniProtKB:O60674

24 April 2018

IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60674&geneProductId=UniProtKB:O60674

interleukin-23-mediated signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

interleukin-6-mediated signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

interleukin-27-mediated signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

interleukin-35-mediated signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

chromatin organization

1 reference

9 May 2019

regulation of receptor signaling pathway via JAK-STAT

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

cytokine-mediated signaling pathway

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

innate immune response

1 reference

9 May 2019

positive regulation of Ras protein signal transduction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

modulation of chemical synaptic transmission

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

postsynapse to nucleus signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

positive regulation of cold-induced thermogenesis

1 reference

9 May 2019

JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

microglial cell activation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

receptor signaling pathway via JAK-STAT

3 references

positive regulation of MHC class II biosynthetic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674

physically interacts with

1 reference

7792

17 August 2016

1 reference

7791

17 August 2016

1 reference

7793

17 August 2016

1 reference

5688

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1078178

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3622821

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1231124

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3545215

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2107823

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3137308

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1944698

has part(s)

tyrosine-protein kinase, active site

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

SH2 domain

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

Band 4.1 domain

1 reference

FERM domain

1 reference

Janus kinase 2, catalytic domain

1 reference

Janus kinase 2, pseudokinase domain

1 reference

Tyrosine-protein kinase JAK2, SH2 domain

1 reference

JAK2, FERM domain C-lobe

1 reference

D08.811.913.696.620.682.725.124.200

Identifiers

MeSH descriptor ID

D053614

subject named as

Janus Kinase 2

0 references

MeSH tree code

0 references

D12.776.476.393.200

0 references

D12.776.624.664.700.117

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1 reference

30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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13 November 2019

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1 reference

9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

1 reference

9 August 2016

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9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

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9 August 2016

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9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

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9 August 2016

1 reference

9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

1 reference

9 August 2016

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9 August 2016

1 reference

9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023