(Q31820996)

English

The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11154688%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11154688%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference

based on heuristic

inferred from title

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11154688%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11154688%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

author name string

Crespo NC

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11154688%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Hamilton AD

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11154688%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Sebti SM

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11154688%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

language of work or name

0 references

publication date

11 January 2001

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11154688%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Journal of Biological Chemistry

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11154688%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

276

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11154688%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

16161-16167

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11154688%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

19

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11154688%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Protein prenylation: molecular mechanisms and functional consequences

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

Increasing complexity of Ras signaling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

Signal transduction. How receptors turn Ras on.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

Inhibition of Ras prenylation: a novel approach to cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

Non-Ras targets of farnesyltransferase inhibitors: focus on Rho.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

CENP-E function at kinetochores is essential for chromosome alignment.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

CENP-E as an essential component of the mitotic checkpoint in vitro.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

Cytoplasmic dynein plays a role in mammalian mitotic spindle formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

Mitotic regulation of microtubule cross-linking activity of CENP-E kinetochore protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006213200

21 January 2018

Identifiers

10.1074/JBC.M006213200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11154688%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11154688%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q31820996&oldid=1976127242"