(Q31956379)

English

Comprehensive survey of chemical libraries yielding enzyme inhibitors, receptor agonists and antagonists, and other biologically active agents: 1992 through 1997.

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

5 July 2017

1 reference

Europe PubMed Central

Comprehensive survey of chemical libraries yielding enzyme inhibitors, receptor agonists and antagonists, and other biologically active agents: 1992 through 1997. (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 July 2017

author name string

Dolle RE

1

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Europe PubMed Central

PubMed publication ID

5 July 2017

publication date

1 January 1997

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Europe PubMed Central

PubMed publication ID

5 July 2017

Molecular Diversity

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Europe PubMed Central

PubMed publication ID

5 July 2017

3

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Europe PubMed Central

PubMed publication ID

5 July 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

5 July 2017

199-233

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Europe PubMed Central

PubMed publication ID

5 July 2017

'Targeted' molecular diversity: design and development of non-peptide antagonists for cholecystokinin and tachykinin receptors

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Deconvolution of combinatorial libraries for drug discovery: experimental comparison of pooling strategies

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Drug leads from combinatorial phosphodiester libraries

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Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(substituted)glycine peptoid library

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Inhibitors of human heart chymase based on a peptide library

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Synthetic peptide combinatorial libraries: a method for the identification of bioactive peptides against phytopathogenic fungi

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Multiple simultaneous synthesis of phenolic libraries.

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Synthesis of potent cyclic hexapeptide NK-1 antagonists. Use of a minilibrary in transforming a peptidal somatostatin receptor ligand into an NK-1 receptor ligand via a polyvalent peptidomimetic

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Selection of a histidine-containing inhibitor of gelatinases through deconvolution of combinatorial tetrapeptide libraries

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Discovery of enzyme inhibitors through combinatorial chemistry

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The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library

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The use of positional scanning synthetic peptide combinatorial libraries for the rapid determination of opioid receptor ligands

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Selection of chymotrypsin inhibitors from a conformationally-constrained combinatorial peptide library

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A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere

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An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library

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Identification of substrate-analog trypsin inhibitors through the screening of synthetic peptide combinatorial libraries

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Identification of a peptide inhibitor against glycosomal phosphoglycerate kinase of Trypanosoma brucei by a synthetic peptide library approach.

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Encoded combinatorial chemistry: synthesis and screening of a library of highly functionalized pyrrolidines

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Development of highly potent and selective phosphinic peptide inhibitors of zinc endopeptidase 24-15 using combinatorial chemistry.

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One bead-one compound combinatorial peptide library: different types of screening

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NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein

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Development of the first potent and selective inhibitor of the zinc endopeptidase neurolysin using a systematic approach based on combinatorial chemistry of phosphinic peptides

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A high-density screening format for encoded combinatorial libraries: assay miniaturization and its application to enzymatic reactions

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Acetalins: opioid receptor antagonists determined through the use of synthetic peptide combinatorial libraries

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The rapid identification of HIV protease inhibitors through the synthesis and screening of defined peptide mixtures

1 reference

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

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A review of the utility of soluble peptide combinatorial libraries.

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Structure optimization of a leukotriene D4 antagonist by combinatorial chemistry in solution

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Novel bradykinin receptor antagonists from a structurally directed non-peptide combinatorial library

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Six highly active mu-selective opioid peptides identified from two synthetic combinatorial libraries

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Expedient method for the solid-phase synthesis of aspartic acid protease inhibitors directed toward the generation of libraries

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Synthesis and Applications of Small Molecule Libraries

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Use of peptide combinatorial libraries in drug design: the identification of a potent serotonin reuptake inhibitor derived from a tripeptide cassette library

1 reference

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Screening a random pentapeptide library, composed of 14 D-amino acids, against the COOH-terminal sequence of fructose-1,6-bisphosphate aldolase from Trypanosoma brucei

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Systematic study of substance P analogs. I. Evaluation of peptides synthesized by the multipin method for quantitative receptor binding assay

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Combinatorial diffusion assay used to identify topically active melanocyte-stimulating hormone receptor antagonists

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Pharmacologic actions of Ro 24-5913, a novel antagonist of leukotriene D4

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Screening and characterization of estrogenic activity from a hydroxystilbene library

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Peptoids: a modular approach to drug discovery.

1 reference

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Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library

1 reference

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Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists

1 reference

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New promise in combinatorial chemistry: synthesis, characterization, and screening of small-molecule libraries in solution

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Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin D.

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Cyclic peptide template combinatorial libraries: synthesis and identification of chymotrypsin inhibitors

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Screening derivatized peptide libraries for tight binding inhibitors to carbonic anhydrase II by electrospray ionization-mass spectrometry

1 reference

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A paradigm for drug discovery employing encoded combinatorial libraries

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A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)

1 reference

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Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery

1 reference

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Novel alpha-glucosidase inhibitors identified using multiple cyclic peptide combinatorial libraries

1 reference

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Synthetic chemical diversity: solid phase synthesis of libraries of C2 symmetric inhibitors of HIV protease containing diamino diol and diamino alcohol cores

1 reference

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Rapid microscale synthesis, a new method for lead optimization using robotics and solution phase chemistry: application to the synthesis and optimization of corticotropin-releasing factor1 receptor antagonists

1 reference

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Identifiers

10.1023/A:1009699413828

1 reference

Europe PubMed Central

PubMed publication ID

5 July 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 July 2017

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