(Q32117273)

6 July 2017

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title

Clinical pharmacokinetics and pharmacodynamics of ifosfamide and its metabolites (English)

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6 July 2017

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Kerbusch T

1

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6 July 2017

de Kraker J

2

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6 July 2017

Keizer HJ

3

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6 July 2017

van Putten JW

4

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6 July 2017

Groen HJ

5

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6 July 2017

Jansen RL

6

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6 July 2017

Schellens JH

7

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6 July 2017

Beijnen JH

8

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6 July 2017

1 January 2001

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Clinical Pharmacokinetics

6 July 2017

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6 July 2017

40

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6 July 2017

41-62

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6 July 2017

1

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https://scigraph.springernature.com/pub.10.2165/00003088-200140010-00004

6 July 2017

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cites work

Urinary excretion of ifosfamide, 4-hydroxyifosfamide, 3- and 2-dechloroethylifosfamide, mesna, and dimesna in patients on fractionated intravenous ifosfamide and concomitant mesna therapy

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12 December 2020

Erythrocytes and the transport of drugs and endogenous compounds

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12 December 2020

Ifosfamide cytotoxicity on human tumor and renal cells: role of chloroacetaldehyde in comparison to 4-hydroxyifosfamide.

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12 December 2020

Cyclophosphamide and ifosfamide metabolites in the cerebrospinal fluid of children.

1 reference

12 December 2020

High-dose chemotherapy regimens for solid tumors

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12 December 2020

Phenobarbital administration does not affect high-dose ifosfamide pharmacokinetics in humans

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12 December 2020

Preferential location of circulating activated cyclophosphamide within the erythrocyte

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12 December 2020

Analytical and preparative high-performance liquid chromatographic separation of the enantiomers of ifosfamide, cyclophosphamide and trofosfamide and their determination in plasma

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12 December 2020

Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes

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12 December 2020

The N-dechloroethylation of ifosfamide: using stereochemistry to obtain an accurate picture of a clinically relevant metabolic pathway

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12 December 2020

Ifosfamide/mesna. A review of its antineoplastic activity, pharmacokinetic properties and therapeutic efficacy in cancer

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12 December 2020

Mobilization of peripheral blood progenitor cells by sequential administration of interleukin-3 and granulocyte-macrophage colony-stimulating factor following polychemotherapy with etoposide, ifosfamide, and cisplatin

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12 December 2020

Interindividual variations in drug disposition. Clinical implications and methods of investigation

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12 December 2020

Partitioning of ifosfamide and its metabolites between red blood cells and plasma

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12 December 2020

Determination of 4-hydroxyifosfamide in biological matrices by high-performance liquid chromatography.

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12 December 2020

Chromatographic analysis of anticancer drugs

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12 December 2020

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12 December 2020

Clinical pharmacokinetics of ifosfamide in combination with N-acetylcysteine

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12 December 2020

The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactions

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12 December 2020

Ifosfamide/mesa and encephalopathy

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12 December 2020

Cyclophosphamide pharmacokinetics: correlation with cardiac toxicity and tumor response

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12 December 2020

Cytochrome P450-based cancer gene therapy: recent advances and future prospects

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12 December 2020

Metabolism of ifosfamide during a 3 day infusion

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12 December 2020

Mesna--a short review

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12 December 2020

Modulation of P450-dependent ifosfamide pharmacokinetics: a better understanding of drug activation in vivo

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12 December 2020

Chromatographic analysis of the enantiomers of ifosfamide and some of its metabolites in plasma and urine

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12 December 2020

Determination of 4-hydroxyifosfamide concomitantly with ifosfamide and its dechloroethylated metabolites using gas chromatography and a nitrogen phosphorus-selective detector

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12 December 2020

Fractionated ifosfamide therapy produces a time-dependent increase in ifosfamide metabolism

1 reference

12 December 2020

Pharmacokinetics of ifosfamide and its enantiomers following a single 1 h intravenous infusion of the racemate in patients with small cell lung carcinoma

1 reference

12 December 2020

Pharmacokinetics of ifosfamide administered according to three different schedules in metastatic soft tissue and bone sarcomas

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12 December 2020

Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles

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12 December 2020

Ifosfamide nephrotoxicity: limited influence of metabolism and mode of administration during repeated therapy in paediatrics

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12 December 2020

High-dose ifosfamide for soft tissue sarcomas: set the scene, or senescence?

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12 December 2020

A simple quantitative HPLC assay for ifosfamide in biological fluids

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12 December 2020

Ifosfamide encephalopathy and methylene-blue: a case report

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12 December 2020

Disposition of ifosfamide in patients receiving ifosfamide infusion therapy for the treatment of cervical carcinoma

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12 December 2020

Immunohistochemical localization of cytochrome P450 3A in human pulmonary carcinomas and normal bronchial tissue

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12 December 2020

Dechloroethylation of ifosfamide and neurotoxicity

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12 December 2020

Use of mesna to prevent ifosfamide-induced urotoxicity

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12 December 2020

Gas chromatographic determination of ifosfamide in microvolumes of urine and plasma

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12 December 2020

Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide

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12 December 2020

Gas chromatographic method for the determination of plasma isophosphamide (NSC-109724)

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12 December 2020

Increased urinary losses of carnitine during ifosfamide chemotherapy

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12 December 2020

The history of ifosfamide

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12 December 2020

Irreversible encephalopathy with ifosfamide/mesna

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12 December 2020

Depletion of circulating cyst(e)ine by oral and intravenous mesna

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12 December 2020

The efficacy and safety of GR38032F in the prophylaxis of ifosfamide-induced nausea and vomiting

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12 December 2020

Toxicity of single- vs. fractionated-dose ifosfamide in non-small cell lung cancer: a multi-center study.

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12 December 2020

Potentiation of ifosfamide neurotoxicity, hematotoxicity, and tubular nephrotoxicity by prior cis-diamminedichloroplatinum(II) therapy

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12 December 2020

Ifosfamide stereoselective dichloroethylation and neurotoxicity

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12 December 2020

Analysis of ifosfamide, 4-hydroxyifosfamide, N2-dechloroethylifosfamide, N3-dechloroethylifosfamide and iphosphoramide mustard in plasma by gas chromatography-mass spectrometry

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12 December 2020

Pharmacokinetics of ifosfamide

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12 December 2020

Saturable metabolism of continuous high-dose ifosfamide with mesna and GM-CSF: a pharmacokinetic study in advanced sarcoma patients. Swiss Group for Clinical Cancer Research (SAKK).

1 reference

12 December 2020

Cytotoxicity, DNA cross-linking, and single strand breaks induced by activated cyclophosphamide and acrolein in human leukemia cells

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12 December 2020

Pharmacokinetics of divided‐dose ifosfamide

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12 December 2020

Ifosfamide encephalopathy: a reappraisal

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12 December 2020

Prolongation of ifosfamide elimination half-life in obese patients due to altered drug distribution

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12 December 2020

Determination of the enantiomers of ifosfamide and its 2- and 3-N-dechloroethylated metabolites in plasma and urine using enantioselective gas chromatography with mass spectrometric detection

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12 December 2020

Determination of ifosfamide, 2- and 3-dechloroethyifosfamide using gas chromatography with nitrogen-phosphorus or mass spectrometry detection

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12 December 2020

A structural basis for a phosphoramide mustard-induced DNA interstrand cross-link at 5'-d(GAC)

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12 December 2020

Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide

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12 December 2020

The kinetics of the auto-induction of ifosfamide metabolism during continuous infusion

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12 December 2020

The initial clinical trial of nitrogen mustard

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12 December 2020

Development of new cancer chemoprevention agents: role of pharmacokinetic/pharmacodynamic and intermediate endpoint biomarker monitoring.

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12 December 2020

Pharmacokinetics of alkylating agents.

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12 December 2020

Pharmacokinetics of ifosfamide, 2- and 3-dechloroethylifosfamide in plasma and urine of cancer patients treated with a 10-day continuous infusion of ifosfamide

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12 December 2020

The bioavailability of oral and intravenous ifosfamide in the treatment of bronchogenic carcinoma

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12 December 2020

The comparative pharmacology of cyclophosphamide and ifosfamide

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12 December 2020

Stereoselective metabolism of ifosfamide by human P-450s 3A4 and 2B6. Favorable metabolic properties of R-enantiomer

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12 December 2020

Prevention of isophosphamide-induced urothelial toxicity with 2-mercaptoethane sulphonate sodium (mesnum) in patients with advanced carcinoma

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12 December 2020

In-vitro metabolism of anti-cancer drugs, methods and applications: paclitaxel, docetaxel, tamoxifen and ifosfamide

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12 December 2020

Enantiomeric separation of R- and S-ifosfamide and their determination in serum from clinical subjects

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12 December 2020

Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture

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12 December 2020

Rapid gas chromatographic determination of ifosfamide in biological fluids

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12 December 2020

The determination of (-)-(S)- and (+)-(R)-ifosfamide in plasma using enantioselective gas chromatography: a validated assay for pharmacokinetic and clinical studies

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12 December 2020

Phenytoin-induced alteration in the N-dechloroethylation of ifosfamide stereoisomers

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12 December 2020

Ifosfamide causes a diazepam-sensitive encephalopathy

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12 December 2020

Kinetics of cyclophosphamide biotransformation in vivo

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12 December 2020

Ifosfamide: should the honeymoon be over?

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12 December 2020

A mechanism-based pharmacokinetic-enzyme model for cyclophosphamide autoinduction in breast cancer patients

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12 December 2020

Hallucinations and ifosfamide-induced neurotoxicity

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12 December 2020

Bioavailability of subcutaneous ifosfamide and feasibility of continuous outpatient application in cancer patients

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12 December 2020

Ifosfamide--pharmacology, safety and therapeutic potential

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12 December 2020

Stereoselective separations of chiral anticancer drugs and their application to pharmacodynamic and pharmacokinetic studies

1 reference

12 December 2020

The analysis of ifosfamide and its metabolites (review).

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12 December 2020

Evaluation of the autoinduction of ifosfamide metabolism by a population pharmacokinetic approach using NONMEM.

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12 December 2020

Ifosfamide and carboplatin combined with 41.8 degrees C whole-body hyperthermia in patients with refractory sarcoma and malignant teratoma.

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12 December 2020

Combined thin-layer chromatography-photography-densitometry for the quantification of ifosfamide and its principal metabolites in urine, cerebrospinal fluid and plasma

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12 December 2020

Role of cytochrome P450 in oxazaphosphorine metabolism. Deactivation via N-dechloroethylation and activation via 4-hydroxylation catalyzed by distinct subsets of rat liver cytochromes P450

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12 December 2020

Nephrotoxicity of ifosfamide--moving towards understanding the molecular mechanisms

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12 December 2020

Inhibition of (mono)amine oxidase activity and prevention of ifosfamide encephalopathy by methylene blue.

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12 December 2020

Metabolism and pharmacokinetics of oral and intravenous ifosfamide

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12 December 2020

Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene.

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12 December 2020

Pharmacokinetics of ifosfamide and some metabolites in children.

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12 December 2020

Leucocyte nadir as a marker for chemotherapy efficacy in node-positive breast cancer treated with adjuvant CMF

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12 December 2020

Ifosfamide cardiotoxicity in humans

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12 December 2020

Gas chromatographic determination of 2- and 3-dechloroethylifosfamide in plasma and urine

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12 December 2020

The oxazaphosphorines

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12 December 2020

Central nervous system toxicity following the treatment of pediatric patients with ifosfamide/mesna

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12 December 2020

Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: development of a combined chemotherapy/cancer gene therapy strategy

1 reference

12 December 2020

The pharmacokinetics and metabolism of ifosfamide during bolus and infusional administration: a randomized cross-over study

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12 December 2020

Pharmacokinetic Model to Describe Self‐Induced Decreases in Steady‐State Concentrations of Carbamazepine

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12 December 2020

Activated oxazaphosphorines are transported predominantly by erythrocytes

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12 December 2020

Intrasubject variation in children of ifosfamide pharmacokinetics and metabolism during repeated administration

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12 December 2020

The effect of ifosfamide and its metabolites on intracellular glutathione levels in vitro and in vivo

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12 December 2020

Fatal Encephalopathy with Ifosfamide/Mesna

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12 December 2020

Ifosfamide continuous infusion without mesna. A phase I trial of a 14-day cycle

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12 December 2020

Measurement of DNA cross-linking in patients on ifosfamide therapy using the single cell gel electrophoresis (comet) assay

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12 December 2020

31P NMR studies of the kinetics of bisalkylation by isophosphoramide mustard: comparisons with phosphoramide mustard

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12 December 2020

Determination of ifosfamide in plasma by gas chromatography with nitrogen detector

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12 December 2020

Pharmacokinetic studies in lung cancer patients

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12 December 2020

Oxazaphosphorine cytostatics: past-present-future. Seventh Cain Memorial Award lecture

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12 December 2020

The effect of route of administration and fractionation of dose on the metabolism of ifosfamide

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12 December 2020

Toxicity, pharmacokinetics, and in vitro hemodialysis clearance of ifosfamide and metabolites in an anephric pediatric patient with Wilms' tumor.

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12 December 2020

Bioavailability of ifosfamide in patients with bronchial carcinoma

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12 December 2020

Prophylaxis and reversal of ifosfamide encephalopathy with methylene-blue.

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12 December 2020

Ifosfamide by continuous infusion to prevent encephalopathy.

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12 December 2020

Quantification by gas chromatography of N,N'-di-(2-chloroethyl)-phosphorodiamidic acid in the plasma of patients receiving isophosphamide

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12 December 2020

Mesna inactivates platinum agents in vitro

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12 December 2020

Ifosfamide with mesna uroprotection in the management of lung cancer

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12 December 2020

Pharmacokinetics, metabolism and clinical effect of ifosfamide in breast cancer patients

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12 December 2020

Depletion of total cysteine, glutathione, and homocysteine in plasma by ifosfamide/mesna therapy

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12 December 2020

Clinical and preclinical modulation of chemotherapy-induced toxicity in patients with cancer

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12 December 2020

Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes

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12 December 2020

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12 December 2020

Ifosfamide-induced neurotoxicity: a case report and review of the literature

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12 December 2020

Interstitial pneumonitis associated with ifosfamide therapy.

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12 December 2020

Formation of chloroethylamine and 1,3-oxazolidine-2-one following ifosfamide administration in humans

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12 December 2020

Determination of the urinary excretion of ifosfamide and its phosphorated metabolites by phosphorus-31 nuclear magnetic resonance spectroscopy

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12 December 2020

Ifosfamide metabolism and pharmacokinetics (review).

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12 December 2020

Alkylating agent resistance: in vitro studies with human cell lines

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12 December 2020

Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes

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12 December 2020

Alkylating activity in serum, urine, and CSF following high-dose ifosfamide in children.

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12 December 2020

The pharmacokinetics of ifosfamide given as short and long intravenous infusions in cancer patients

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12 December 2020

Renal dysfunctions secondary to ifosfamide treatment in children

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12 December 2020

2-Chloroacetaldehyde-induced cerebral glutathione depletion and neurotoxicity

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12 December 2020

Determination of chloroacetaldehyde, a metabolite of oxazaphosphorine cytostatic drugs, in plasma

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12 December 2020

Prediction of ifosfamide/mesna associated encephalopathy

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12 December 2020

Ifosfamide induced stress response in human lymphocytes

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12 December 2020

Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

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12 December 2020

Ifosfamide-induced nephrotoxicity in children: critical review of predictive risk factors

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12 December 2020

Combined intravenous and oral mesna in outpatients treated with ifosfamide

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12 December 2020

Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines

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12 December 2020

The determination of cyclophosphamide and its metabolites in blood plasma as stable trifluoroacetyl derivatives by electron capture chemical ionization gas chromatography/mass spectrometry

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12 December 2020

Ifosfamide enantiomers: pharmacokinetics in children

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12 December 2020

Ifosfamide, mesna, and nephrotoxicity in children

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12 December 2020

Excretion kinetics of ifosfamide side-chain metabolites in children on continuous and short-term infusion

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12 December 2020

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12 December 2020

Isophosphoramide mustard, a metabolite of ifosfamide with activity against murine tumours comparable to cyclophosphamide

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12 December 2020

Comparison of continuous infusion and bolus administration of ifosfamide in children

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12 December 2020

Efficacy and toxicity of ifosfamide stereoisomers in an in vivo rat mammary carcinoma model

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12 December 2020

Inhibition and stimulation of long-chain fatty acid oxidation by chloroacetaldehyde and methylene blue in rats

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12 December 2020

High-performance liquid chromatographic determination of stabilized 4-hydroxyifosfamide in human plasma and erythrocytes

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12 December 2020

A study of 5 day fractionated ifosfamide pharmacokinetics in consecutive treatment cycles

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12 December 2020

Comparative pharmacokinetics and alkylating activity of fractionated intravenous and oral ifosfamide in patients with bronchogenic carcinoma

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12 December 2020

Stereoselective pharmacokinetics of ifosfamide and its 2- and 3-N-dechloroethylated metabolites in female cancer patients

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12 December 2020

A new approach to the study of ifosfamide metabolism by the analysis of human body fluids with 31P nuclear magnetic resonance spectroscopy

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12 December 2020

Methylene blue and the neurotoxic mechanisms of ifosfamide encephalopathy

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12 December 2020

Methylene blue for ifosfamide-associated encephalopathy

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12 December 2020

Determination of urinary 2- and 3-dechloroethylated metabolites of ifosfamide by high-performance liquid chromatography

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12 December 2020

Pharmacokinetics and metabolism of ifosfamide administered as a continuous infusion in children

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12 December 2020

Renal clearance of ifosfamide

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12 December 2020

Ifosfamide metabolite chloroacetaldehyde causes Fanconi syndrome in the perfused rat kidney

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12 December 2020

Studies on the metabolism of isopnosphamide (NSC-109724) in man

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12 December 2020

Ifosfamide encephalopathy.

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12 December 2020

Mechanistic aspects of the cytotoxic activity of glufosfamide, a new tumour therapeutic agent

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12 December 2020

Oxazaphosphorine toxicity reduction by mesna

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12 December 2020

Comparative pharmacokinetics of oral and intravenous ifosfamide/mesna/methylene blue therapy.

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12 December 2020

High-dose ifosfamide, carboplatin, and etoposide pharmacokinetics: correlation of plasma drug levels with renal toxicity

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12 December 2020

Pharmacokinetic modelling of ifosfamide administered by continuous infusion on 5 days at the dose of 6 g/m2.

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12 December 2020

Pharmacokinetics of "activated" cyclophosphamide and therapeutic efficacies

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12 December 2020

Determination of ifosfamide by HPLC using on-line sample preparation

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12 December 2020

Drug resistance in the treatment of sarcomas

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12 December 2020

Cytochrome P-450 spin state: inorganic biochemistry of haem iron ligation and functional significance

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12 December 2020

Ifosfamide clinical pharmacokinetics

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12 December 2020

The enigma of ifosfamide encephalopathy.

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12 December 2020

Urinary excretion of the enantiomers of ifosfamide and its inactive metabolites in children

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12 December 2020

L-carnitine: a way to decrease cellular toxicity of ifosfamide?

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12 December 2020

Basis and new developments in the field of oxazaphosphorines

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12 December 2020

Characterization and quantitative estimation of activated cyclophosphamide in blood and urine

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12 December 2020

Ifosfamide extrapyramidal neurotoxicity

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12 December 2020

Effect of chirality on pharmacokinetics and pharmacodynamics

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12 December 2020

Ifosfamide pharmacokinetics and neurotoxicity

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12 December 2020

Time course of enzyme induction in humans: effect of pentobarbital on nortriptyline metabolism.

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12 December 2020

Ifosfamide extrapyramidal neurotoxicity

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12 December 2020

The leucocyte nadir, a predictor of chemotherapy efficacy?

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12 December 2020

Identification and quantification of metabolite conjugates of activated cyclophosphamide and ifosfamide with mesna in urine by ion-pair extraction and fast atom bombardment mass spectrometry.

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12 December 2020

The effect of age on the pharmacokinetics of ifosfamide

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12 December 2020

Metabolism of oxazaphosphorines

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12 December 2020

Rapid method for the determination of ifosfamide and cyclophosphamide in plasma by high-performance liquid chromatography with solid-phase extraction

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12 December 2020

Analysis of ifosforamide mustard, the active metabolite of ifosfamide, in plasma

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12 December 2020

Comparative pharmacokinetics of ifosfamide, 4-hydroxyifosfamide, chloroacetaldehyde, and 2- and 3-dechloroethylifosfamide in patients on fractionated intravenous ifosfamide therapy

1 reference

12 December 2020

10.2165/00003088-200140010-00004

Identifiers

DOI

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Dimensions Publication ID

6 July 2017

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