(Q33204326)

23 July 2017

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title

AMPA receptor ligands: synthetic and pharmacological studies of polyamines and polyamine toxins (English)

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23 July 2017

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1

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Ian R Mellor

object named as

Ian Mellor

series ordinal

2

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publication date

1 September 2004

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Medicinal Research Reviews

23 July 2017

published in

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23 July 2017

volume

24

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23 July 2017

issue

5

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23 July 2017

page(s)

589-620

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23 July 2017

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Polyamine-dependent gene expression

21 January 2018

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Targeting ionotropic receptors with polyamine-containing toxins

21 January 2018

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Modulation and block of ion channels: a new biology of polyamines

21 January 2018

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Terminally alkylated polyamine analogues as chemotherapeutic agents.

21 January 2018

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Nicotinic receptors at the amino acid level

21 January 2018

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Cloning by functional expression of a member of the glutamate receptor family

21 January 2018

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Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development

21 January 2018

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Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA

21 January 2018

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Molecular cloning and characterization of the rat NMDA receptor

21 January 2018

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Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain

21 January 2018

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Unraveling the modular design of glutamate-gated ion channels

21 January 2018

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An early Cambrian craniate-like chordate

21 January 2018

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N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1.

21 January 2018

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Topology profile for a glutamate receptor: three transmembrane domains and a channel-lining reentrant membrane loop.

21 January 2018

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Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins

21 January 2018

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New class of glutamate agonist structurally related to ibotenic acid

21 January 2018

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New developments in the molecular pharmacology of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate and kainate receptors

21 January 2018

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Glutamate receptors in the mammalian central nervous system

21 January 2018

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The structure and function of glutamate receptor ion channels

21 January 2018

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Structure of a glutamate-receptor ligand-binding core in complex with kainate

21 January 2018

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Glutamate-operated channels: developmentally early and mature forms arise by alternative splicing.

21 January 2018

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The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

21 January 2018

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A synaptic model of memory: long-term potentiation in the hippocampus

21 January 2018

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Long-term depression: a cascade of induction and expression mechanisms.

21 January 2018

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Long-term potentiation--a decade of progress?

21 January 2018

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Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmann glia

21 January 2018

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Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala

21 January 2018

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Role of AMPA receptor endocytosis in synaptic plasticity

21 January 2018

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Restless AMPA receptors: implications for synaptic transmission and plasticity

21 January 2018

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AMPA receptor trafficking and synaptic plasticity

21 January 2018

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Receptor trafficking and the plasticity of excitatory synapses.

21 January 2018

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Regulation of AMPA receptors during synaptic plasticity

21 January 2018

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Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons

21 January 2018

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Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons

21 January 2018

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Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction

21 January 2018

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Ligands for glutamate receptors: design and therapeutic prospects

21 January 2018

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Mechanism of glutamate receptor desensitization

21 January 2018

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Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity

21 January 2018

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GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists

21 January 2018

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Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX

21 January 2018

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Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core

21 January 2018

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Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal

21 January 2018

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Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate

21 January 2018

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Structural basis for partial agonist action at ionotropic glutamate receptors

21 January 2018

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Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core

21 January 2018

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Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes

21 January 2018

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The glutamate AMPA receptor antagonist, YM872, attenuates cortical tissue loss, regional cerebral edema, and neurological motor deficits after experimental brain injury in rats

21 January 2018

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Effect of AMPA receptor antagonist YM872 on cerebral hematoma size and neurological recovery in the intracerebral hemorrhage rat model

21 January 2018

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Talampanel, a new antiepileptic drug: single- and multiple-dose pharmacokinetics and initial 1-week experience in patients with chronic intractable epilepsy

21 January 2018

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Atropisomeric quinazolin-4-one derivatives are potent noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists

21 January 2018

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Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist

21 January 2018

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CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo

21 January 2018

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Functional characterization of YM928, a novel moncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist

21 January 2018

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Argiotoxin detects molecular differences in AMPA receptor channels.

21 January 2018

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Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives.

21 January 2018

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Differential blocking action of Joro spider toxin analog on parallel fiber and climbing fiber synapses in cerebellar Purkinje cells

21 January 2018

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Blocking effect of 1-naphthyl acetyl spermine on Ca(2+)-permeable AMPA receptors in cultured rat hippocampal neurons.

21 January 2018

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Ca2+-Zn2+ permeable AMPA or kainate receptors: possible key factors in selective neurodegeneration

21 January 2018

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The GluR2 (GluR-B) hypothesis: Ca(2+)-permeable AMPA receptors in neurological disorders

21 January 2018

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Inward rectification of both AMPA and kainate subtype glutamate receptors generated by polyamine-mediated ion channel block

21 January 2018

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Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification

21 January 2018

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Strong voltage-dependent inward rectification of inward rectifier K+ channels is caused by intracellular spermine.

21 January 2018

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Facilitation of currents through rat Ca2+-permeable AMPA receptor channels by activity-dependent relief from polyamine block

21 January 2018

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Polyamine-dependent facilitation of postsynaptic AMPA receptors counteracts paired-pulse depression

21 January 2018

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A short-term mechanism of plasticity for interneurones?

21 January 2018

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An activity-dependent spermine-mediated mechanism that modulates glutamate transmission

21 January 2018

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Visually driven modulation of glutamatergic synaptic transmission is mediated by the regulation of intracellular polyamines

21 January 2018

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Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues

21 January 2018

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Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist.

21 January 2018

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Synthesis and high performance liquid chromatography/electrospray mass spectrometry single-bead decoding of split-pool structural libraries of polyamines supported on polystyrene and polystyrene/ethylene glycol resins.

21 January 2018

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Combinatorial approach to selective multivalent ion pairing in mixed aqueous-organic media using bead-supported libraries of unnatural polyamines.

21 January 2018

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A mild and general solid-phase method for the synthesis of chiral polyamines. Solution studies on the cleavage of borane-amine intermediates from the reduction of secondary amides.

21 January 2018

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Solid phase syntheses of polyamine toxins HO-416b and PhTX-433. Use of an efficient polyamide reduction strategy that facilitates access to branched analogues.

21 January 2018

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A sequential high-yielding large-scale solution-method for synthesis of philanthotoxin analogues

21 January 2018

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An efficient and versatile synthesis of acylpolyamine spider toxins

21 January 2018

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Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor.

21 January 2018

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Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors

21 January 2018

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Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors

21 January 2018

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Synthesis of diaminobutane derivatives as potent Ca(2+)-permeable AMPA receptor antagonists

21 January 2018

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Discovery of diaminobutane derivatives as Ca(2+)-permeable AMPA receptor antagonists

21 January 2018

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Arthropod toxins as leads for novel insecticides: an assessment of polyamine amides as glutamate antagonists

21 January 2018

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Preparation and biological assessment of hydroxycinnamic acid amides of polyamines

21 January 2018

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Synthesis and paralytic activities of squaryl amino acid-containing polyamine toxins.

21 January 2018

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Spider toxin blocks excitatory amino acid responses in isolated hippocampal pyramidal neurons

21 January 2018

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Dissociation between the Joro spider toxin sensitivity of recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors and their ability to increase intracellular calcium

21 January 2018

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Ca2+ permeability and joro spider toxin sensitivity of AMPA and kainate receptors on cerebellar granule cells

21 January 2018

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The open channel blocking drug, IEM-1460, reveals functionally distinct alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors in rat brain neurons

21 January 2018

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Evaluation of GluR2 subunit involvement in AMPA receptor function of neonatal rat hypoglossal motoneurons

21 January 2018

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Afferent-specific innervation of two distinct AMPA receptor subtypes on single hippocampal interneurons

21 January 2018

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Studies of the structure of glutamate receptor ion channels and the mechanisms of their blockade by organic cations.

21 January 2018

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Amino acid substitutions in the pore of rat glutamate receptors at sites influencing block by polyamines

21 January 2018

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The role of hydrophobic interactions in binding of polyamines to non NMDA receptor ion channels

21 January 2018

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Channel blockers acting at N-methyl-D-aspartate receptors: differential effects of mutations in the vestibule and ion channel pore.

21 January 2018

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Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines.

21 January 2018

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NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines.

21 January 2018

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Structure-activity relationships of analogues of the wasp toxin philanthotoxin: non-competitive antagonists of quisqualate receptors.

21 January 2018

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Single channel studies of non-competitive antagonism of a quisqualate-sensitive glutamate receptor by argiotoxin636--a fraction isolated from orb-web spider venom.

21 January 2018

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Spermine and philanthotoxin potentiate excitatory amino acid responses of Xenopus oocytes injected with rat and chick brain RNA

21 January 2018

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Characterisation of kainate receptor mediated whole-cell currents in rat cultured cerebellar granule cells

21 January 2018

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Argiotoxin636 inhibits NMDA-activated ion channels expressed in Xenopus oocytes

21 January 2018

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A highly potent and selective N-methyl-D-aspartate receptor antagonist from the venom of the Agelenopsis aperta spider

21 January 2018

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Subunit-specific block of cloned NMDA receptors by argiotoxin636.

21 January 2018

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Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B

21 January 2018

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Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+.

21 January 2018

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Molecular diversity of the NMDA receptor channel

21 January 2018

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Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

21 January 2018

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Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons.

21 January 2018

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Cloning and characterization of a novel NMDA receptor subunit NR3B: a dominant subunit that reduces calcium permeability.

21 January 2018

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Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors

21 January 2018

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Inhibition of nicotinic acetylcholine receptor by philanthotoxin-343: kinetic investigations in the microsecond time region using a laser-pulse photolysis technique

21 January 2018

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Polymethylene tetramines: a new generation of selective muscarinic antagonists

21 January 2018

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Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 2. Role of polymethylene chain lengths separating amine functions and of substituents on the terminal nitrogen atoms

21 January 2018

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Location of the polyamine binding site in the vestibule of the nicotinic acetylcholine receptor ion channel

21 January 2018

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Modulation of the nicotinic acetylcholine receptor channels by spermine in Xenopus muscle cell culture.

21 January 2018

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Synthesis of Polyamines, Their Derivatives, Analogues and Conjugates

21 January 2018

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Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure

21 January 2018

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The Acylpolyamines from the Venom of the SpiderAgelenopsis aperta

21 January 2018

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Identifiers

DOI

10.1002/MED.20004

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23 July 2017

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