(Q33205160)

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Tumor necrosis factor alpha sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-kappaB.

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Europe PubMed Central

PubMed publication ID

23 July 2017

Tumor necrosis factor alpha sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-kappaB. (English)

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Europe PubMed Central

PubMed publication ID

23 July 2017

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author name string

Karin Schmelz

1

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Europe PubMed Central

PubMed publication ID

23 July 2017

Thomas Wieder

2

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Europe PubMed Central

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23 July 2017

Ingo Tamm

3

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Europe PubMed Central

PubMed publication ID

23 July 2017

Antje Müller

4

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Europe PubMed Central

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23 July 2017

Frank Essmann

5

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Europe PubMed Central

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23 July 2017

Christoph-C Geilen

6

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Europe PubMed Central

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23 July 2017

Klaus Schulze-Osthoff

7

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Europe PubMed Central

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23 July 2017

Bernd Dörken

8

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23 July 2017

Peter-T Daniel

9

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23 July 2017

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1 September 2004

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Europe PubMed Central

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23 July 2017

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23 July 2017

23

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23 July 2017

40

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Europe PubMed Central

PubMed publication ID

23 July 2017

6743-6759

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Europe PubMed Central

PubMed publication ID

23 July 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1207848

0 references

Modulation of life and death by the TNF receptor superfamily

1 reference

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Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells

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Characterization of a novel Hodgkin cell line, HD-MyZ, with myelomonocytic features mimicking Hodgkin's disease in severe combined immunodeficient mice.

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21 January 2018

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

1 reference

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21 January 2018

Ionizing radiation and the activation of caspase-8 in highly apoptosis-sensitive lymphoma cells.

1 reference

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21 January 2018

A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis

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21 January 2018

Cell death beyond apoptosis

1 reference

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Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

1 reference

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21 January 2018

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

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21 January 2018

Blocking NF-kappaB activation in Jurkat leukemic T cells converts the survival agent and tumor promoter PMA into an apoptotic effector.

1 reference

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21 January 2018

TRAF1 is a TNF inducible regulator of NF-kappaB activation.

1 reference

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TRAF2 plays a dual role in NF-kappaB-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and IkappaB kinase pathways.

1 reference

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21 January 2018

FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis

1 reference

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21 January 2018

Activation and activation-induced death of human tonsillar B cells and Burkitt lymphoma cells: lack of CD95 (Fas/APO-1) ligand expression and function

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Guardians of cell death: the Bcl-2 family proteins

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21 January 2018

The kiss of death: promises and failures of death receptors and ligands in cancer therapy

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The differential sensitivity of Bc1-2-overexpressing human breast tumor cells to TRAIL or doxorubicin-induced apoptosis is dependent on Bc1-2 protein levels.

1 reference

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21 January 2018

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

1 reference

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21 January 2018

The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases

1 reference

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21 January 2018

APO-I-mediated apoptosis in normal and malignant lymphocytes

1 reference

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21 January 2018

Involvement of caspase-2 long isoform in Fas-mediated cell death of human leukemic cells.

1 reference

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21 January 2018

Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling

1 reference

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21 January 2018

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

1 reference

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21 January 2018

Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance

1 reference

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21 January 2018

Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression.

1 reference

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21 January 2018

The vitamin D3 analogue, calcipotriol, induces sphingomyelin hydrolysis in human keratinocytes

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Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity

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21 January 2018

Bcl-x(L) prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis

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21 January 2018

Functions of ceramide in coordinating cellular responses to stress

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Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-x(L) in a strictly caspase-3-dependent manner in human carcinoma cells

1 reference

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21 January 2018

Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis

1 reference

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21 January 2018

Crosstalk between NF-kappaB-activating and apoptosis-inducing proteins of the TNF-receptor complex

1 reference

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21 January 2018

Ionizing radiation but not anticancer drugs causes cell cycle arrest and failure to activate the mitochondrial death pathway in MCF-7 breast carcinoma cells

1 reference

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21 January 2018

Resistance to the cytotoxic effects of tumor necrosis factor alpha can be overcome by inhibition of a FADD/caspase-dependent signaling pathway

1 reference

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21 January 2018

Resistance of mitochondrial DNA-deficient cells to TRAIL: role of Bax in TRAIL-induced apoptosis

1 reference

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21 January 2018

Sensitivity of Ewing's sarcoma to TRAIL-induced apoptosis

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21 January 2018

Involvement of sphingomyelinases in TNF signaling pathways

1 reference

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21 January 2018

Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

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The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice.

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Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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Sensitization to death receptor cytotoxicity by inhibition of fas-associated death domain protein (FADD)/caspase signaling. Requirement of cell cycle progression

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21 January 2018

Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia.

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FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

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Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

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Caspase-2-induced apoptosis is dependent on caspase-9, but its processing during UV- or tumor necrosis factor-dependent cell death requires caspase-3

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Regulation of Ikappa B kinase (IKK)gamma /NEMO function by IKKbeta -mediated phosphorylation

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The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines

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Identification and characterization of an IkappaB kinase

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Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis

1 reference

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The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

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Caspase activation: the induced-proximity model

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TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase

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Adenovirus-mediated wild-type-p53-gene expression sensitizes TNF-resistant tumor cells to TNF-induced cytotoxicity by altering the cellular redox state

1 reference

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Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD.

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21 January 2018

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

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21 January 2018

High constitutive level of NF-kappaB is crucial for viability of adenocarcinoma cells

1 reference

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Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.

1 reference

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Caspase-2 redux

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Suppression of TNF-alpha-induced apoptosis by NF-kappaB

1 reference

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Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop

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Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells

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How are the regulators regulated? The search for mechanisms that impose specificity on induction of cell death and NF-kappaB activation by members of the TNF/NGF receptor family

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Tumor necrosis factor receptor and Fas signaling mechanisms.

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NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

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Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3.

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Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog, hexadecylphosphocholine

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Enhanced tumor killing by Apo2L/TRAIL and CPT-11 co-treatment is associated with p21 cleavage and differential regulation of Apo2L/TRAIL ligand and its receptors

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Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

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FLICE Induced Apoptosis in a Cell-free System

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Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis

1 reference

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7 January 2021

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Sensitization of resistant lymphoma cells to irradiation-induced apoptosis by the death ligand TRAIL

1 reference

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7 January 2021

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High-titer packaging cells producing recombinant retroviruses resistant to human serum

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Bax deficiency affects caspase-2 activation during ultraviolet radiation-induced apoptosis

1 reference

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7 January 2021

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inferred from DOI database lookup

Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts

1 reference

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inferred from DOI database lookup

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10.1038/SJ.ONC.1207848

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Europe PubMed Central

PubMed publication ID

23 July 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 July 2017

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