(Q33226231)

24 July 2017

1 reference

title

Improving success rates for lead generation using affinity binding technologies (English)

1 reference

24 July 2017

Gergely M Makara

1

1 reference

PubMed ID

16257522

24 July 2017

John Athanasopoulos

series ordinal

2

1 reference

24 July 2017

28 October 2005

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Current Opinion in Biotechnology

24 July 2017

1 reference

24 July 2017

16

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24 July 2017

6

1 reference

24 July 2017

666-673

1 reference

Capillary electrophoretic approach to screen for enzyme inhibitors in natural extracts

24 July 2017

1 reference

12 December 2020

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design

1 reference

12 December 2020

Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization

1 reference

12 December 2020

Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor

1 reference

12 December 2020

Allosteric inhibition of PTP1B activity by selective modification of a non-active site cysteine residue

1 reference

12 December 2020

Ligand efficiency: a useful metric for lead selection

1 reference

12 December 2020

Fragment-based lead discovery using X-ray crystallography.

1 reference

12 December 2020

The evolution of the matrix metalloproteinase inhibitor drug discovery program at abbott laboratories

1 reference

12 December 2020

Discovery of novel inhibitors of Bcl-xL using multiple high-throughput screening platforms

1 reference

12 December 2020

Frontal affinity chromatography-mass spectrometry assay technology for multiple stages of drug discovery: applications of a chromatographic biosensor

1 reference

12 December 2020

A small molecule-kinase interaction map for clinical kinase inhibitors

1 reference

12 December 2020

Discovery of an allosteric site in the caspases

1 reference

12 December 2020

Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions

1 reference

12 December 2020

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

12 December 2020

A new strategy for improved secondary screening and lead optimization using high-resolution SPR characterization of compound-target interactions

1 reference

12 December 2020

A general technique to rank protein-ligand binding affinities and determine allosteric versus direct binding site competition in compound mixtures

1 reference

12 December 2020

Probing affinity via capillary electrophoresis: advances in 2003-2004.

1 reference

12 December 2020

SpeedScreen: label-free liquid chromatography-mass spectrometry-based high-throughput screening for the discovery of orphan protein ligands

1 reference

12 December 2020

Frontal affinity chromatography with MS detection (FAC-MS) in drug discovery

1 reference

12 December 2020

A reagent-based strategy for the design of large combinatorial libraries: a preliminary experimental validation

1 reference

12 December 2020

Chemical proteomic analysis reveals alternative modes of action for pyrido[2,3-d]pyrimidine kinase inhibitors.

1 reference

12 December 2020

NMR-driven discovery of benzoylanthranilic acid inhibitors of far upstream element binding protein binding to the human oncogene c-myc promoter.

1 reference

12 December 2020

Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells

1 reference

12 December 2020

Discovery of a New Phosphotyrosine Mimetic for PTP1B Using Breakaway Tethering

1 reference

12 December 2020

Custom chemical microarray production and affinity fingerprinting for the S1 pocket of factor VIIa

1 reference

12 December 2020

Discovery and Structure−Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B

1 reference

12 December 2020

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

12 December 2020

Affinity-based screening techniques for enhancing lead discovery.

1 reference

12 December 2020

TINS, target immobilized NMR screening: an efficient and sensitive method for ligand discovery

1 reference

12 December 2020

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

1 reference

12 December 2020

Discovery and characterization of cooperative ligand binding in the adaptive region of interleukin-2

1 reference

12 December 2020

Leveraging structural approaches: applications of NMR-based screening and X-ray crystallography for inhibitor design.

1 reference

12 December 2020

High-affinity small molecule inhibitors of T cell costimulation: compounds for immunotherapy.

1 reference

12 December 2020

Design of a compound screening collection for use in high throughput screening

1 reference

12 December 2020

Characteristic physical properties and structural fragments of marketed oral drugs.

1 reference

12 December 2020

Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases

1 reference

12 December 2020

An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.

1 reference

12 December 2020

Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation.

1 reference

12 December 2020

Discovery of aminoglycoside mimetics by NMR-based screening of Escherichia coli A-site RNA.

1 reference

12 December 2020

SpeedScreen: The "missing link" between genomics and lead discovery

1 reference

12 December 2020

Pursuing the leadlikeness concept in pharmaceutical research.

1 reference

12 December 2020

Multitarget Affinity/Specificity Screening of Natural Products: Finding and Characterizing High-Affinity Ligands from Complex Mixtures by Using High-Performance Mass Spectrometry

1 reference

12 December 2020

Druggability indices for protein targets derived from NMR-based screening data

1 reference

12 December 2020

Applications of affinity interactions in capillary electrophoresis

1 reference

12 December 2020

Evaluation of kinase inhibitor selectivity by chemical proteomics

1 reference

12 December 2020

Site-specific disulfide capture of agonist and antagonist peptides on the C5a receptor

1 reference

12 December 2020

10.1016/J.COPBIO.2005.10.007

Identifiers

DOI

1 reference

release_k4qduymys5blzhry3decpxiacq

24 July 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/k4qduymys5blzhry3decpxiacq

24 November 2022

mapped directly with Wikidata item

1 reference

https://api.fatcat.wiki/v0/release/k4qduymys5blzhry3decpxiacq

24 November 2022

mapped directly with Wikidata item

PubMed ID

16257522

1 reference

PubMed ID

16257522