(Q33229925)

24 July 2017

title

Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function (English)

1 reference

ORCID Public Data File 2021

24 July 2017

1 reference

author name string

K Scott Weber

1

1 reference

24 July 2017

David L Donermeyer

2

1 reference

24 July 2017

Paul M Allen

3

1 reference

24 July 2017

David M Kranz

4

1 reference

24 July 2017

language of work or name

English

0 references

publication date

19 December 2005

1 reference

Proceedings of the National Academy of Sciences of the United States of America

24 July 2017

published in

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24 July 2017

volume

102

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24 July 2017

issue

52

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24 July 2017

page(s)

19033-19038

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T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell.

24 July 2017

cites work

1 reference

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21 June 2018

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High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3.

21 June 2018

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CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse

21 June 2018

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Dissecting the binding energy epitope of a high-affinity variant of human growth hormone: cooperative and additive effects from combining mutations from independently selected phage display mutagenesis libraries

21 June 2018

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Peptide-MHC class II dimers as therapeutics to modulate antigen-specific T cell responses in autoimmune diabetes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1323173

TCRs with high affinity for foreign pMHC show self-reactivity

21 June 2018

1 reference

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Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

21 June 2018

1 reference

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Positive and negative selection of T cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1323173

CD8(-) T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1323173

A comparative analysis of the immunological evolution of antibody 28B4

21 June 2018

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Kinetics and thermodynamics of T cell receptor- autoantigen interactions in murine experimental autoimmune encephalomyelitis

21 June 2018

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Structural and functional consequences of altering a peptide MHC anchor residue

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1323173

Breaking the affinity ceiling for antibodies and T cell receptors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1323173

In vitro evolution of a T cell receptor with high affinity for peptide/MHC.

21 June 2018

1 reference

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Differential requirements for CD4 in TCR-ligand interactions

21 June 2018

1 reference

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A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1323173

Selection of functional T cell receptor mutants from a yeast surface-display library

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1323173

Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1323173

Yeast surface display for screening combinatorial polypeptide libraries

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1323173

Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1323173

Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology

21 June 2018

1 reference

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The law of mass action governs antigen-stimulated cytolytic activity of CD8+ cytotoxic T lymphocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1323173

Formation of functional peptide complexes of class II major histocompatibility complex proteins from subunits produced in Escherichia coli

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1323173

High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1323173

Kinetic proofreading in T-cell receptor signal transduction

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1323173

Serial triggering of many T-cell receptors by a few peptide-MHC complexes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1323173

Ligand recognition by alpha beta T cell receptors

21 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0507554102

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0507554102

Two-step binding mechanism for T-cell receptor recognition of peptide MHC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0507554102

Directed evolution of a stable scaffold for T-cell receptor engineering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0507554102

Dissecting cooperative and additive binding energetics in the affinity maturation pathway of a protein-protein interface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0507554102

Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0507554102

Direct observation of ligand recognition by T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0507554102

Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0507554102

Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1323173

Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties

31 October 2018

1 reference

12 December 2020

Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

1 reference

12 December 2020

Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand

1 reference

12 December 2020

Complete dissection of the Hb(64-76) determinant using T helper 1, T helper 2 clones, and T cell hybridomas

1 reference

12 December 2020

Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response

1 reference

12 December 2020

High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0507554102

1 reference

24 July 2017

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24 July 2017

1 reference