(Q36045188)

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How T cells 'see' antigen

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scholarly article

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Europe PubMed Central

PubMed publication ID

11 August 2017

1 reference

Europe PubMed Central

How T cells 'see' antigen (English)

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Europe PubMed Central

PubMed publication ID

11 August 2017

author name string

Michelle Krogsgaard

1

1 reference

Europe PubMed Central

PubMed publication ID

11 August 2017

Mark M Davis

2

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Europe PubMed Central

PubMed publication ID

11 August 2017

language of work or name

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publication date

1 March 2005

1 reference

Europe PubMed Central

PubMed publication ID

11 August 2017

Nature Immunology

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Europe PubMed Central

PubMed publication ID

11 August 2017

6

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Europe PubMed Central

PubMed publication ID

11 August 2017

3

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Europe PubMed Central

PubMed publication ID

11 August 2017

239-245

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Europe PubMed Central

PubMed publication ID

11 August 2017

Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Ligand recognition by alpha beta T cell receptors

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Molecular interactions mediating T cell antigen recognition

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Molecular mechanisms determining the strength of receptor-mediated intermembrane adhesion

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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The kinetics of protein-protein recognition.

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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The crystal structure of a T cell receptor in complex with peptide and MHC class II

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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A functional hot spot for antigen recognition in a superagonist TCR/MHC complex

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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CDR3 loop flexibility contributes to the degeneracy of TCR recognition

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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A structural basis for immunodominant human T cell receptor recognition

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Structural Comparison of Allogeneic and Syngeneic T Cell Receptor–Peptide-Major Histocompatibility Complex Complexes

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

based on heuristic

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Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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TCR binding to peptide-MHC stabilizes a flexible recognition interface

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Thermodynamics of T cell receptor binding to peptide-MHC: evidence for a general mechanism of molecular scanning

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Kinetics and thermodynamics of T cell receptor- autoantigen interactions in murine experimental autoimmune encephalomyelitis

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Distinct molecular mechanisms account for the specificity of two different T-cell receptors

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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The immunological evolution of catalysis

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Structural insights into the evolution of an antibody combining site

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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The interplay between binding energy and catalysis in the evolution of a catalytic antibody

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

based on heuristic

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The specificity of TCR/pMHC interaction

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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What do TCR-pMHC crystal structures teach us about MHC restriction and alloreactivity?

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

based on heuristic

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The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

based on heuristic

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Receptor proximity, not intermolecular orientation, is critical for triggering T-cell activation

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

based on heuristic

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The MHC reactivity of the T cell repertoire prior to positive and negative selection.

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Control of MHC restriction by TCR Valpha CDR1 and CDR2

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Two-step binding mechanism for T-cell receptor recognition of peptide MHC.

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Selecting and maintaining a diverse T-cell repertoire

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Recognition of multiple peptide cores by a single T cell receptor

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: implications for TCR signaling.

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

based on heuristic

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Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

based on heuristic

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A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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T-cell-receptor affinity and thymocyte positive selection

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Peptide antagonism and T cell receptor interactions with peptide-MHC complexes

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

based on heuristic

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Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

based on heuristic

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The minimal number of class II MHC-antigen complexes needed for T cell activation

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Minimal requirements for peptide mediated activation of CD8+ CTL.

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

based on heuristic

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Determination of the relationship between T cell responsiveness and the number of MHC-peptide complexes using specific monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Direct observation of ligand recognition by T cells.

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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T cell killing does not require the formation of a stable mature immunological synapse.

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Elaborate interactions between the immune and nervous systems

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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How photons start vision

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Initiation of signal transduction by receptor aggregation: role of nonreceptor tyrosine kinases

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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CD8 Expression Allows T Cell Signaling by Monomeric Peptide-MHC Complexes

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Soluble peptide-MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Erratum: Costimulation and endogenous MHC ligands contribute to T cell recognition

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Serial triggering of many T-cell receptors by a few peptide-MHC complexes

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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TCRs with high affinity for foreign pMHC show self-reactivity

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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The T-cell receptor signalosome: a dynamic structure with expanding complexity

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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How the immune system works to protect the host from infection: a personal view

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Differential clustering of CD4 and CD3zeta during T cell recognition

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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Continuous T cell receptor signaling required for synapse maintenance and full effector potential

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https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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The immunological synapse balances T cell receptor signaling and degradation

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

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T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4.

1 reference

https://api.crossref.org/works/10.1038%2FNI1173

7 January 2021

based on heuristic

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Identifiers

1 reference

Europe PubMed Central

PubMed publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 August 2017

ResearchGate publication ID

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