(Q33232270)

24 July 2017

Directed evolution of adeno-associated virus yields enhanced gene delivery vectors (English)

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24 July 2017

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Narendra Maheshri

1

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24 July 2017

James T Koerber

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2

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24 July 2017

Brian K Kaspar

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3

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24 July 2017

David V Schaffer

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4

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24 July 2017

22 January 2006

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24 July 2017

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24 July 2017

24

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24 July 2017

2

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24 July 2017

198-204

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https://scigraph.springernature.com/pub.10.1038/nbt1182

24 July 2017

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cites work

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Adeno-associated viruses undergo substantial evolution in primates during natural infections

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Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector.

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AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.

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Repeated adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: a multicenter, double-blind, placebo-controlled trial

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The cryptic life style of adeno-associated virus

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Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypes

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Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors

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Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors

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Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector

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Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

21 January 2018

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21 January 2018

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Epitope mapping of human anti-adeno-associated virus type 2 neutralizing antibodies: implications for gene therapy and virus structure

21 January 2018

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21 January 2018

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21 January 2018

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Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain

21 January 2018

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Convection-enhanced delivery of AAV-2 combined with heparin increases TK gene transfer in the rat brain.

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21 January 2018

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21 January 2018

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Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2.

21 January 2018

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Insertional mutagenesis of the adeno-associated virus type 2 (AAV2) capsid gene and generation of AAV2 vectors targeted to alternative cell-surface receptors

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Rapid evolution of a protein in vitro by DNA shuffling

21 January 2018

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Inverting enantioselectivity by directed evolution of hydantoinase for improved production of L-methionine

21 January 2018

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Yeast surface display for screening combinatorial polypeptide libraries

21 January 2018

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Quantitative analysis of the effect of the mutation frequency on the affinity maturation of single chain Fv antibodies

21 January 2018

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Molecular breeding of viruses

21 January 2018

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Molecular evolution by staggered extension process (StEP) in vitro recombination

21 January 2018

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Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

21 January 2018

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Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity

21 January 2018

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Genetic modifications of the adeno-associated virus type 2 capsid reduce the affinity and the neutralizing effects of human serum antibodies

21 January 2018

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Clades of Adeno-associated viruses are widely disseminated in human tissues.

21 January 2018

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Impaired intracellular trafficking of adeno-associated virus type 2 vectors limits efficient transduction of murine fibroblasts

21 January 2018

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Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transfer

21 January 2018

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Transfer of high copy number plasmid into mammalian cells by calcium phosphate transfection

21 January 2018

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Identification of a heparin-binding motif on adeno-associated virus type 2 capsids

21 January 2018

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Nucleotide sequence and organization of the adeno-associated virus 2 genome

21 January 2018

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7 January 2021

Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector

1 reference

7 January 2021

Genetics of adeno-associated virus: isolation and preliminary characterization of adeno-associated virus type 2 mutants

1 reference

7 January 2021

Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2.

1 reference

7 January 2021

Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions

1 reference

7 January 2021

Structural studies on antibody interacting with viruses

1 reference

7 January 2021

Identifiers

DOI

10.1038/NBT1182

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24 July 2017

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