(Q33278117)

25 July 2017

1 reference

title

Advances in ischemic stroke treatment: neuroprotective and combination therapies (English)

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25 July 2017

Paul A Lapchak

1

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author name string

Dalia M Araujo

series ordinal

2

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25 July 2017

language of work or name

English

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publication date

1 March 2007

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Expert Opinion on Emerging Drugs

25 July 2017

published in

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25 July 2017

volume

12

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25 July 2017

issue

1

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25 July 2017

page(s)

97-112

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Hemorrhagic transformation following ischemic stroke: significance, causes, and relationship to therapy and treatment

25 July 2017

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Coadministration of NXY-059 and tenecteplase six hours following embolic strokes in rabbits improves clinical rating scores

21 January 2018

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Postischemic intracarotid treatment with TNK-tPA reduces infarct volume and improves neurological deficits in embolic stroke in the unanesthetized rat.

21 January 2018

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A pilot dose-escalation safety study of tenecteplase in acute ischemic stroke

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Neuroprotective effects of the spin trap agent disodium-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) in a rabbit small clot embolic stroke model: combination studies with the thrombolytic tissue plasminogen activator

21 January 2018

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Potential markers of oxidative stress in stroke.

21 January 2018

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Reducing bleeding complications after thrombolytic therapy for stroke: clinical potential of metalloproteinase inhibitors and spin trap agents

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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NXY-059 for acute ischemic stroke

21 January 2018

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3alpha-OL-5-beta-pregnan-20-one hemisuccinate, a steroidal low-affinity NMDA receptor antagonist improves clinical rating scores in a rabbit multiple infarct ischemia model: synergism with tissue plasminogen activator

21 January 2018

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Lost in translation: taking neuroprotection from animal models to clinical trials.

21 January 2018

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Ebselen, a seleno-organic antioxidant, is neuroprotective after embolic strokes in rabbits: synergism with low-dose tissue plasminogen activator

21 January 2018

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Pharmacological effects of the spin trap agents N-t-butyl-phenylnitrone (PBN) and 2,2,6, 6-tetramethylpiperidine-N-oxyl (TEMPO) in a rabbit thromboembolic stroke model: combination studies with the thrombolytic tissue plasminogen activator

21 January 2018

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Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.12.1.97

Pharmacologic properties of phenyl N-tert-butylnitrone

21 January 2018

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Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat.

21 January 2018

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Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat.

21 January 2018

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NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species

21 January 2018

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Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window

21 January 2018

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In vitro blood-brain barrier permeability and cerebral endothelial cell uptake of the neuroprotective nitrone compound NXY-059 in normoxic, hypoxic and ischemic conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.12.1.97

Effects of the spin trap agent disodium- [tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) on intracerebral hemorrhage in a rabbit Large clot embolic stroke model: combination studies with tissue plasminogen activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.12.1.97

The neuroprotective agent ebselen modifies NMDA receptor function via the redox modulatory site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.12.1.97

Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia

21 January 2018

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Ebselen: prospective therapy for cerebral ischaemia

21 January 2018

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Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group

21 January 2018

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Ebselen in acute middle cerebral artery occlusion: a placebo-controlled, double-blind clinical trial.

21 January 2018

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Stilbazulenyl nitrone (STAZN): a nitronyl-substituted hydrocarbon with the potency of classical phenolic chain-breaking antioxidants

21 January 2018

1 reference

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Stilbazulenyl nitrone, a novel azulenyl nitrone antioxidant: improved neurological deficit and reduced contusion size after traumatic brain injury in rats

21 January 2018

1 reference

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Stilbazulenyl nitrone, a novel antioxidant, is highly neuroprotective in focal ischemia

21 January 2018

1 reference

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Stilbazulenyl nitrone, a second-generation azulenyl nitrone antioxidant, confers enduring neuroprotection in experimental focal cerebral ischemia in the rat: neurobehavior, histopathology, and pharmacokinetics

21 January 2018

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Kinetic studies on stilbazulenyl-bis-nitrone (STAZN), a nonphenolic chain-breaking antioxidant in solution, micelles, and lipid membranes

21 January 2018

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A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities

21 January 2018

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Matrix metalloproteinases in brain injury

21 January 2018

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Matrix metalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke.

21 January 2018

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Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke.

21 January 2018

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Matrix metalloproteinase-9 concentration after spontaneous intracerebral hemorrhage.

21 January 2018

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Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures.

21 January 2018

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Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview

21 January 2018

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Matrix metalloproteinases in cerebrovascular disease

21 January 2018

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Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size

21 January 2018

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Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia.

21 January 2018

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Metalloproteinase inhibition blocks edema in intracerebral hemorrhage in the rat.

21 January 2018

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Increased therapeutic efficacy with rt-PA and anti-CD18 antibody treatment of stroke in the rat.

21 January 2018

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Effects of a selective CD11b/CD18 antagonist and recombinant human tissue plasminogen activator treatment alone and in combination in a rat embolic model of stroke

21 January 2018

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Acute Stroke Therapy by Inhibition of Neutrophils (ASTIN): an adaptive dose-response study of UK-279,276 in acute ischemic stroke

21 January 2018

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Postischemic (6-Hour) treatment with recombinant human tissue plasminogen activator and proteasome inhibitor PS-519 reduces infarction in a rat model of embolic focal cerebral ischemia

21 January 2018

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Oral glycoprotein IIb/IIIa antagonism in patients with coronary artery disease

21 January 2018

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Neuroprotective effect of SolCD39, a novel platelet aggregation inhibitor, on transient middle cerebral artery occlusion in rats.

21 January 2018

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Dynamic platelet accumulation at the site of the occluded middle cerebral artery and in downstream microvessels is associated with loss of microvascular integrity after embolic middle cerebral artery occlusion

21 January 2018

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Therapeutic potential of platelet glycoprotein IIb/IIIa receptor antagonists in the management of ischemic stroke.

21 January 2018

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The nonpeptide glycoprotein IIb/IIIa platelet receptor antagonist SM-20302 reduces tissue plasminogen activator-induced intracerebral hemorrhage after thromboembolic stroke

21 January 2018

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Early abciximab administration in acute myocardial infarction treated with primary coronary intervention.

21 January 2018

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Effects of abciximab on microvascular integrity and left ventricular functional recovery in patients with acute infarction treated by primary coronary angioplasty.

21 January 2018

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Thrombolytics, anticoagulants, and antiplatelet agents

21 January 2018

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The use of abciximab in the treatment of acute cerebral thromboembolic events during neuroendovascular procedures.

21 January 2018

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Ongoing and planned trials of antiplatelet therapy in the acute and long-term management of patients with ischaemic brain syndromes: setting a new standard of care

21 January 2018

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Previous use of aspirin and baseline stroke severity: an analysis of 17,850 patients in the International Stroke Trial

21 January 2018

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Transcranial application of low-energy laser irradiation improves neurological deficits in rats following acute stroke.

21 January 2018

1 reference

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Effects of power densities, continuous and pulse frequencies, and number of sessions of low-level laser therapy on intact rat brain

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.12.1.97

Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.12.1.97

Impact of low level laser irradiation on infarct size in the rat following myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.12.1.97

Promotion of angiogenesis by low energy laser irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.12.1.97

Modulations of VEGF and iNOS in the rat heart by low level laser therapy are associated with cardioprotection and enhanced angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.12.1.97

Transcranial infrared laser therapy improves clinical rating scores after embolic strokes in rabbits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.12.1.97

Intravenous ancrod for acute ischaemic stroke in the European Stroke Treatment with Ancrod Trial: a randomised controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.12.1.97

Carbamylated erythropoietin ameliorates the metabolic stress induced in vivo by severe chronic hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.12.1.97

Neurophysiological consequences of nitroxide antioxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.12.1.97

Excretion, metabolism and tissue distribution of a spin trapping agent, alpha-phenyl-N-tert-butyl-nitrone (PBN) in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.12.1.97

Low-energy laser irradiation enhances de novo protein synthesis via its effects on translation-regulatory proteins in skeletal muscle myoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.12.1.97

Contraindications of VEGF-based therapeutic angiogenesis: effects on macrophage density and histology of normal and ischemic brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.12.1.97

Tissue plasminogen activator reduces neurological damage after cerebral embolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.12.1.97

Tissue plasminogen activator. Reduction of neurologic damage after experimental embolic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.12.1.97

The validity of rodent brain-ischemia models is self-evident

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.12.1.97

One-year follow-up of the ASSENT-2 trial: A double-blind, randomized comparison of single-bolus tenecteplase and front-loaded alteplase in 16,949 patients with ST-elevation acute myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.12.1.97

21 January 2018

Identifiers

DOI

10.1517/14728214.12.1.97

1 reference

25 July 2017

1 reference