(Q33323032)

25 July 2017

title

Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila (English)

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25 July 2017

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Shuang Chang

1

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25 July 2017

Steven M Bray

2

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25 July 2017

Zigang Li

3

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25 July 2017

Daniela C Zarnescu

4

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25 July 2017

Chuan He

5

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25 July 2017

Peng Jin

6

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25 July 2017

Stephen T Warren

7

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25 July 2017

publication date

9 March 2008

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25 July 2017

published in

Nature Chemical Biology

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25 July 2017

volume

4

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25 July 2017

issue

4

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25 July 2017

page(s)

256-263

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The pathophysiology of fragile x syndrome.

25 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association

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7 January 2021

The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95

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7 January 2021

Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome

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7 January 2021

Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function

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7 January 2021

The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesis.

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7 January 2021

The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development.

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7 January 2021

RNA and microRNAs in fragile X mental retardation

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7 January 2021

The mGluR theory of fragile X mental retardation

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Differential translation and fragile X syndrome

1 reference

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7 January 2021

Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome

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7 January 2021

Understanding fragile X syndrome: insights from retarded flies

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7 January 2021

Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Control of dendritic development by theDrosophila fragile X-relatedgene involves the small GTPase Rac1

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Defective neuronal development in the mushroom bodies of Drosophila fragile X mental retardation 1 mutants.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

The Drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects

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7 January 2021

The importance of company: Na+ and Cl- influence substrate interaction with SLC6 transporters and other proteins.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Stimulation of muscarinic receptors mimics experience-dependent plasticity in the honey bee brain

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7 January 2021

Propagation of olfactory information in Drosophila.

1 reference

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7 January 2021

Role of GABAergic inhibition in shaping odor-evoked spatiotemporal patterns in the Drosophila antennal lobe.

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7 January 2021

Mushroom body memoir: from maps to models

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

1 reference

7 January 2021

Conditioned responses in courtship behavior of normal and mutant Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Altered synaptic function in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Biologically active molecules that reduce polyglutamine aggregation and toxicity

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Forward chemical genetic approach identifies new role for GAPDH in insulin signaling

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Identification of novel antimicrobials using a live-animal infection model

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Invertebrate animal models of diseases as screening tools in drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Nucleus accumbens acetylcholine regulates appetitive learning and motivation for food via activation of muscarinic receptors

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Genetic deletion of CB1 receptors improves non-associative learning.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Memory impairment induced by cholinergic antagonists injected into the mushroom bodies of the honeybee

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Decreased expression of the GABAA receptor in fragile X syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Expression profiling suggests underexpression of the GABA(A) receptor subunit delta in the fragile X knockout mouse model

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Decreased GABA(A) receptor expression in the seizure-prone fragile X mouse.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Major defects in neocortical GABAergic inhibitory circuits in mice lacking the fragile X mental retardation protein

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Formation of dendritic spines in cultured striatal neurons depends on excitatory afferent activity

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

gamma-Aminobutyric acid receptor distribution in the mushroom bodies of a fly (Calliphora erythrocephala): a functional subdivision of Kenyon cells?

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Three classes of GABA-like immunoreactive neurons in the mushroom body of the cockroach

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.78

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO.78

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25 July 2017

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