(Q33352582)

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Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds

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scholarly article

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Europe PubMed Central

PubMed publication ID

26 July 2017

Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds (English)

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Europe PubMed Central

PubMed publication ID

26 July 2017

drug interaction

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author name string

Michael Zientek

1

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Europe PubMed Central

PubMed publication ID

26 July 2017

Howard Miller

2

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Europe PubMed Central

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26 July 2017

Danielle Smith

3

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Europe PubMed Central

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26 July 2017

Mary Beth Dunklee

4

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Europe PubMed Central

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26 July 2017

Lance Heinle

5

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Europe PubMed Central

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26 July 2017

Archie Thurston

6

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26 July 2017

Caroline Lee

7

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26 July 2017

Ruth Hyland

8

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26 July 2017

Odette Fahmi

9

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26 July 2017

Douglas Burdette

10

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26 July 2017

publication date

25 June 2008

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26 July 2017

Journal of Pharmacological and Toxicological Methods

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26 July 2017

58

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26 July 2017

3

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26 July 2017

206-214

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26 July 2017

High-throughput screening for stability and inhibitory activity of compounds toward cytochrome P450-mediated metabolism

1 reference

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Use of heterologously expressed human cytochrome P4501A2 to predict tacrine-fluvoxamine drug interaction in man

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The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

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Substrate-dependent competition of different P450 isozymes for limiting NADPH-cytochrome P450 reductase

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Characterization of the inhibition of P4501A2 by furafylline

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In vitro drug interactions of cytochrome p450: an evaluation of fluorogenic to conventional substrates

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In vitro LC-MS cocktail assays to simultaneously determine human cytochrome P450 activities

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Assessment of CYP1A2 activity in clinical practice: why, how, and when?

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Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans

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The stoichiometry of the cytochrome P-450-catalyzed metabolism of methoxyflurane and benzphetamine in the presence and absence of cytochrome b5.

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Role of itraconazole metabolites in CYP3A4 inhibition

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Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions

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7 January 2021

Testosterone 1 beta-hydroxylation by human cytochrome P450 3A4.

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Cytochrome P450 3A4-catalyzed testosterone 6beta-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting steps

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Stereochemical aspects of itraconazole metabolism in vitro and in vivo

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Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline

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Pharmacokinetic and Pharmacodynamic Interactions of Oral Midazolam with Ketoconazole, Fluoxetine, Fluvoxamine, and Nefazodone

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CYP2D6 inhibition by selective serotonin reuptake inhibitors: analysis of achievable steady-state plasma concentrations and the effect of ultrarapid metabolism at CYP2D6.

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Consumption of charcoal-broiled meat as an experimental tool for discerning CYP1A2-mediated drug metabolism in vivo

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Tacrine is not an ideal probe drug for measuring CYP1A2 activity in vivo

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Cytochrome P450TB (CYP2C): a major monooxygenase catalyzing diclofenac 4'-hydroxylation in human liver

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Mechanistic enzymology of oxygen activation by the cytochromes P450.

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Impact of Nonspecific Binding to Microsomes and Phospholipid on the Inhibition of Cytochrome P4502D6: Implications for Relating in Vitro Inhibition Data to in Vivo Drug Interactions

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Measurement of Michaelis constants for cytochrome P450-mediated biotransformation reactions using a substrate depletion approach

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Measurement of human liver microsomal cytochrome P450 2D6 activity using [O-methyl-14C]dextromethorphan as substrate

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Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2

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7 January 2021

Analytical approaches to determine cytochrome P450 inhibitory potential of new chemical entities in drug discovery

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Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms

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7 January 2021

High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry

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7 January 2021

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential--toward a consensus

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7 January 2021

Validated assays for human cytochrome P450 activities

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Selective inhibition of human cytochrome P4502C8 by montelukast

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Hierarchical Grouping to Optimize an Objective Function

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Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation

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Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. V. Competition between cytochromes P-450 and P-448 for reductase in 3,4-benzpyrene hydroxylation

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Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios

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Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4'-hydroxylation

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Rapid and quantitative determination of metabolites from multiple cytochrome P450 probe substrates by gradient liquid chromatography-electrospray ionization-ion trap mass spectrometry

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High throughput P450 inhibition screens in early drug discovery

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Identifiers

10.1016/J.VASCN.2008.05.131

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

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