(Q33368199)

26 July 2017

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title

Molecular pathogenesis of colorectal cancer (English)

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26 July 2017

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Hoops TC

1

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26 July 2017

Traber PG

series ordinal

2

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26 July 2017

publication date

1 August 1997

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Hematology / Oncology Clinics of North America

26 July 2017

published in

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26 July 2017

volume

11

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26 July 2017

issue

4

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26 July 2017

page(s)

609-633

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Overexpression of p53 and long-term survival in colon carcinoma

26 July 2017

cites work

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7 January 2021

The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase

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7 January 2021

Hereditary nonpolyposis colorectal cancer: review of clinical, molecular genetics, and counseling aspects

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7 January 2021

APC gene: database of germline and somatic mutations in human tumors and cell lines

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7 January 2021

Activation of pp60c-src protein kinase activity in human colon carcinoma

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7 January 2021

p21ras: An oncoprotein functioning in growth factor-induced signal transduction

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7 January 2021

Molecular assessment of histopathological staging in squamous-cell carcinoma of the head and neck

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7 January 2021

Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer

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7 January 2021

Loss of APC protein expressed by human colonic epithelial cells and the appearance of a specific low-molecular-weight form is associated with apoptosis in vitro

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7 January 2021

Elevated c-Src tyrosine kinase activity in premalignant epithelia of ulcerative colitis

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7 January 2021

pp60c-src activation in human colon carcinoma

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7 January 2021

Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis

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https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

cDCC (chicken homologue to a gene deleted in colorectal carcinoma) is an epithelial adhesion molecule expressed in the basal cells and involved in epithelial-mesenchymal interaction

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https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Unraveling the cytoplasmic interactions of the cadherin superfamily

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7 January 2021

Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer

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7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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7 January 2021

Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

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https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors

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https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

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https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Identification of a chromosome 18q gene that is altered in colorectal cancers

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https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

A genetic model for colorectal tumorigenesis

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7 January 2021

Presence of a potent transcription activating sequence in the p53 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis

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https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

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https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Aspirin and the Risk of Colorectal Cancer in Women

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https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Identification and characterization of the familial adenomatous polyposis coli gene

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

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https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Association of p53 mutations with short survival in colorectal cancer

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https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

The molecular basis of Turcot's syndrome

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https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

The DCC gene product in cellular differentiation and colorectal tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

A human homologue of the rat metastasis-associated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Gardner syndrome in a man with an interstitial deletion of 5q.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Decreased expression of DCC mRNA in human colorectal cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Allelic loss of chromosome 18q and prognosis in colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Identification of p53 as a sequence-specific DNA-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Identification of FAP locus genes from chromosome 5q21

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers

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https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

p53: puzzle and paradigm

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

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https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

T antigen is bound to a host protein in SY40-transformed cells

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https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

The gene for familial polyposis coli maps to the long arm of chromosome 5.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

The spectrum of mutations at the p53 locus. Evidence for tissue-specific mutagenesis, selection of mutant alleles, and a "gain of function" phenotype

1 reference

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7 January 2021

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Update on the differential diagnosis, surveillance and management of hereditary non-polyposis colorectal cancer

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https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch Syndrome).

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Signal transduction through beta-catenin and specification of cell fate during embryogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

The evolution of cancer of the colon and rectum

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Mutations of two PMS homologues in hereditary nonpolyposis colon cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Restriction of ocular fundus lesions to a specific subgroup of APC mutations in adenomatous polyposis coli patients.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Concordant p53 and DCC alterations and allelic losses on chromosomes 13q and 14q associated with liver metastases of colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Src activity increases and Yes activity decreases during mitosis of human colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Expression of a homologue of the deleted in colorectal cancer (DCC) gene in the nervous system of developing Xenopus embryos.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

APC mutations occur early during colorectal tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Age of onset in familial adenomatous polyposis: heterogeneity within families and among APC mutations.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

K-ras mutations in putative preneoplastic lesions in human colon

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Patients with adenomatous polyps and carcinomas have increased colonic mucosal prostaglandin E2

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Increased p53 protein content of colorectal tumours correlates with poor survival.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

A constitutional 5q23 deletion

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

CD44 expression patterns in breast and colon tumors: a PCR-based study of splice variants

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Identification and quantification of aberrant crypt foci and microadenomas in the human colon.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Cellular localisation of c-myc product in human colorectal epithelial neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Association of the APC gene product with beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

The DCC protein and prognosis in colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

c-myc oncogene expression in colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Over-expression of the c-myc proto-oncogene in colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Chromosome 5 allele loss in human colorectal carcinomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Alleles of the APC gene: an attenuated form of familial polyposis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Association of the APC tumor suppressor protein with catenins

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Somatic alterations of the DPC4 gene in human colorectal cancers in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Genetic alterations during colorectal-tumor development

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Differential pp60c-src activity in well and poorly differentiated human colon carcinomas and cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Expression of a CD44 variant containing exons 8 to 10 is a useful independent factor for the prediction of prognosis in colorectal cancer patients

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

Detection of exfoliated carcinoma cells in colonic luminal washings by identification of deranged patterns of expression of the CD44 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2805%2970453-6

7 January 2021

10.1016/S0889-8588(05)70453-6

Identifiers

DOI

1 reference

26 July 2017

1 reference