(Q33371141)

26 July 2017

Phase II trial of R115777 (NSC #70818) in patients with advanced colorectal cancer: a Southwest Oncology Group study (English)

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26 July 2017

phase II clinical trial

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10

Southwest Oncology Group

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26 July 2017

7

Heinz-Josef Lenz

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26 July 2017

Robert P Whitehead

1

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26 July 2017

Sheryl McCoy

2

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26 July 2017

John S Macdonald

3

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26 July 2017

Saul E Rivkin

4

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26 July 2017

Marcus A Neubauer

5

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26 July 2017

Shaker R Dakhil

6

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26 July 2017

Michael S Tanaka

8

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26 July 2017

James L Abbruzzese

9

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26 July 2017

1 July 2006

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Investigational New Drugs

26 July 2017

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26 July 2017

24

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26 July 2017

4

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26 July 2017

335-341

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https://scigraph.springernature.com/pub.10.1007/s10637-005-4345-3

26 July 2017

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cites work

Therapeutics targeting signal transduction for patients with colorectal carcinoma

1 reference

12 December 2020

Stability of K-ras mutations throughout the natural history of human colorectal cancer

1 reference

12 December 2020

Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer

1 reference

12 December 2020

New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

1 reference

12 December 2020

Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarcinoma

1 reference

12 December 2020

Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956

1 reference

12 December 2020

Molecular genetic studies of the adenoma-carcinoma sequence.

1 reference

12 December 2020

Cancer statistics, 2004

1 reference

12 December 2020

Genetic epidemiology of mutated K-ras proto-oncogene, altered suppressor genes, and microsatellite instability in colorectal adenomas

1 reference

12 December 2020

A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines

1 reference

12 December 2020

Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer

1 reference

12 December 2020

Prevalence of ras gene mutations in human colorectal cancers

1 reference

12 December 2020

Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models

1 reference

12 December 2020

Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer

1 reference

12 December 2020

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

1 reference

12 December 2020

FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study

1 reference

12 December 2020

Targeting RAS signalling pathways in cancer therapy

1 reference

12 December 2020

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

1 reference

12 December 2020

Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a Southwest Oncology Group study.

1 reference

12 December 2020

Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group

1 reference

12 December 2020

Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer

1 reference

12 December 2020

Prediction of outcome after curative resection for large bowel cancer

1 reference

12 December 2020

Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.

1 reference

12 December 2020

Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial

1 reference

12 December 2020

Homologies between signal transducing G proteins and ras gene products

1 reference

12 December 2020

Ras p21: effects and regulation

1 reference

12 December 2020

From bench top to bedside

1 reference

12 December 2020

Opinion: Searching for the elusive targets of farnesyltransferase inhibitors

1 reference

12 December 2020

Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer

1 reference

12 December 2020

10.1007/S10637-005-4345-3

Identifiers

DOI

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Dimensions Publication ID

26 July 2017

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1 reference