(Q33376941)

26 July 2017

title

The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor (English)

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26 July 2017

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Leonard B Saltz

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author name string

Kyle Holen

1

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26 July 2017

Ellen Hollywood

3

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26 July 2017

Konrad Burk

4

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26 July 2017

Axel-Rainer Hanauske

5

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26 July 2017

publication date

9 October 2007

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Investigational New Drugs

26 July 2017

published in

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26 July 2017

volume

26

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26 July 2017

issue

1

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26 July 2017

page(s)

45-51

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https://scigraph.springernature.com/pub.10.1007/s10637-007-9083-2

26 July 2017

exact match

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cites work

DNA fragmentation and NAD depletion. Their relation to the turnover of endogenous mono(ADP-ribosyl) and poly(ADP-ribosyl) proteins

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12 December 2020

Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress

1 reference

12 December 2020

WK175, a novel antitumor agent, decreases the intracellular nicotinamide adenine dinucleotide concentration and induces the apoptotic cascade in human leukemia cells

1 reference

12 December 2020

Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma.

1 reference

12 December 2020

Metabolic signatures associated with a NAD synthesis inhibitor-induced tumor apoptosis identified by 1H-decoupled-31P magnetic resonance spectroscopy

1 reference

12 December 2020

FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis

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12 December 2020

DNA-damage and NAD(+)-depletion are initial events in oxygen radical induced islet cell death

1 reference

12 December 2020

Chemotherapeutically induced DNA damage, ATP depletion, and the apoptotic biochemical cascade

1 reference

12 December 2020

Depletion of nicotinamide adenine dinucleotide in normal and xeroderma pigmentosum fibroblast cells by the antitumor drug CC-1065

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12 December 2020

Depletion of intracellular NAD(+) and ATP levels during ricin-induced apoptosis through the specific ribosomal inactivation results in the cytolysis of U937 cells

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12 December 2020

Reporting results of cancer treatment

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12 December 2020

Poly(ADP-ribose) biosynthesis and suicidal NAD+ depletion following carcinogen exposure of mammalian cells.

1 reference

12 December 2020

NAD+ depletion and cytotoxicity in isolated hepatocytes

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12 December 2020

Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transition

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12 December 2020

10.1007/S10637-007-9083-2

Identifiers

DOI

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Dimensions Publication ID

26 July 2017

1036949014

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