(Q33380531)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662289%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

title

Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662289%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference

0 references

1 reference

1

1 reference

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11 January 2020

Koen Vandenbroeck

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662289%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

author name string

Jeff S Millership

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662289%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Paul S Collier

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662289%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Anthony McCarthy

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662289%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Sid Dempsey

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662289%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Carole Cairns

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662289%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

John Collins

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662289%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Colin Rodgers

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662289%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

James C McElnay

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662289%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

language of work or name

English

0 references

publication date

28 June 2008

1 reference

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British Journal of Clinical Pharmacology

11 January 2020

published in

1 reference

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11 January 2020

volume

66

1 reference

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11 January 2020

issue

4

1 reference

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11 January 2020

page(s)

517-528

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662289%20AND%20SRC:MED&resulttype=core&format=json

Review article: thiopurines in inflammatory bowel disease

11 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Thiopurine S-methyltransferase pharmacogenetics: insights, challenges and future directions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Mutation in the ITPA gene predicts intolerance to azathioprine

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Analytic aspects of monitoring therapy with thiopurine medications

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Pharmacogenetic determinants of outcome in acute lymphoblastic leukaemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Pharmacogenomics and "individualized drug therapy": high expectations and disappointing achievements

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Pharmacogenomics of azathioprine and 6-mercaptopurine in gastroenterologic therapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Treatment of inflammatory bowel disease in childhood: best available evidence

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Optimizing treatment with thioguanine derivatives in inflammatory bowel disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Therapeutic drug monitoring of cytotoxic drugs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

New developments in the immunosuppressive drug monitoring of cyclosporine, tacrolimus, and azathioprine

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Therapeutic drug monitoring of antimetabolic cytotoxic drugs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Pharmacogenetics of cancer therapy: getting personal

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Cellular pharmacology of 6-mercaptopurine in acute lymphoblastic leukemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Quantitation of 6-thioguanine residues in peripheral blood leukocyte DNA obtained from patients receiving 6-mercaptopurine-based maintenance therapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Analysis of serial measurements in medical research

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Human liver xanthine oxidase: Nature and extent of individual variation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

The clinical pharmacology of 6-mercaptopurine

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

RBC 6-TGN and hematological parameters in patients with Crohn's disease treated by azathioprine

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Thiopurine methyltransferase and 6-thioguanine nucleotide measurement: early experience of use in clinical practice.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

ITPA genotyping test does not improve detection of Crohn's disease patients at risk of azathioprine/6-mercaptopurine induced myelosuppression

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Pharmacokinetics of 6-mercaptopurine in patients with inflammatory bowel disease: implications for therapy

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Clinical use and practical application of TPMT enzyme and 6-mercaptopurine metabolite monitoring in IBD.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

TPMT in the treatment of Crohn's disease with azathioprine

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Inhibition of mammalian xanthine oxidase by folate compounds and amethopterin.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561120

Application of pharmacogenetics to optimization of mercaptopurine dosing

31 October 2018

1 reference

12 December 2020

Thiopurine pharmacogenetics: clinical and molecular studies of thiopurine methyltransferase

1 reference

12 December 2020

Variable bioavailability of oral mercaptopurine. Is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered?

1 reference

12 December 2020

Analysis of thiopurine methyltransferase variant alleles in childhood acute lymphoblastic leukaemia

1 reference

12 December 2020

BASIC BIOCHEMICAL EFFECTS AND MECHANISM OF ACTION OF 6-THIOGUANINE

1 reference

12 December 2020

Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

1 reference

12 December 2020

Purine substrates for human thiopurine methyltransferase

1 reference

12 December 2020

Risk of relapse in childhood acute lymphoblastic leukemia is related to RBC methotrexate and mercaptopurine metabolites during maintenance chemotherapy. Nordic Society for Pediatric Hematology and Oncology

1 reference

12 December 2020

Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia

1 reference

12 December 2020

Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase

1 reference

12 December 2020

10.1111/J.1365-2125.2008.03248.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662289%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662289%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

PubMed publication ID

18662289

1 reference