(Q36426772)

14 August 2017

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title

Thiopurine S-methyltransferase pharmacogenetics: insights, challenges and future directions (English)

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14 August 2017

Wang L

1

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14 August 2017

Weinshilboum R

series ordinal

2

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14 August 2017

language of work or name

English

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publication date

1 March 2006

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14 August 2017

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14 August 2017

volume

25

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14 August 2017

issue

11

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14 August 2017

page(s)

1629-1638

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209372

14 August 2017

exact match

0 references

cites work

Human estrogen sulfotransferase (SULT1E1) pharmacogenomics: gene resequencing and functional genomics

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7 January 2021

BiDil raises questions about race as a marker

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7 January 2021

Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes

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7 January 2021

The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations

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7 January 2021

6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease.

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7 January 2021

Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia

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7 January 2021

Functional characterization of the human thiopurine S-methyltransferase (TPMT) gene promoter.

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7 January 2021

Human sulfotransferase SULT1C1 pharmacogenetics: gene resequencing and functional genomic studies

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7 January 2021

Hassles with taking out the garbage: aggravating aggresomes.

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Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease

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7 January 2021

Identification and functional analysis of two rare allelic variants of the thiopurine S-methyltransferase gene, TPMT*16 and TPMT*19.

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7 January 2021

Purification and properties of 5-phosphoribosyl pyrophosphate amidotransferase from adenocarcinoma 755 cells

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7 January 2021

From the cradle to the grave: molecular chaperones that may choose between folding and degradation

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7 January 2021

Polymorphism of the thiopurine S-methyltransferase gene in African-Americans

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7 January 2021

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing.

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7 January 2021

Human phenylethanolamine N-methyltransferase pharmacogenomics: gene re-sequencing and functional genomics

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7 January 2021

Cytoplasmic dynein/dynactin mediates the assembly of aggresomes

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7 January 2021

Aggresomes: a cellular response to misfolded proteins

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7 January 2021

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

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7 January 2021

Aggresomes, inclusion bodies and protein aggregation

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7 January 2021

Drug methylation in cancer therapy: lessons from the TPMT polymorphism

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A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase

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The clinical pharmacology of 6-mercaptopurine

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Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

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Childhood leukaemia: a relationship between intracellular 6-mercaptopurine metabolites and neutropenia

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Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations

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7 January 2021

Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism

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7 January 2021

Identification of two novel sequence variants affecting thiopurine methyltransferase enzyme activity.

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7 January 2021

Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia

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7 January 2021

ERAD: the long road to destruction

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7 January 2021

Pharmacogenomics and "individualized drug therapy": high expectations and disappointing achievements

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7 January 2021

Hsp90 inhibitors as novel cancer chemotherapeutic agents

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Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms

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7 January 2021

Human thiopurine methyltransferase pharmacogenetics. Kindred with a terminal exon splice junction mutation that results in loss of activity

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7 January 2021

High incidence of secondary brain tumours after radiotherapy and antimetabolites.

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7 January 2021

Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics

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7 January 2021

Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants

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7 January 2021

A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ALL.

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7 January 2021

Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population.

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7 January 2021

Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism

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7 January 2021

Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: mechanism for TPMT protein deficiency inherited by TPMT*2, TPMT*3A, TPMT*3B or TPMT*3C

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7 January 2021

Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity

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7 January 2021

Inhibition of phosphoribosyl pyrophosphate amidotransferase from Ehrlich ascites-tumour cells by thiopurine nucleotides

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209372

7 January 2021

Human sulfotransferase SULT2A1 pharmacogenetics: genotype-to-phenotype studies

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209372

7 January 2021

Human catecholamine sulfotransferase (SULT1A3) pharmacogenetics: functional genetic polymorphism

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7 January 2021

Thiopurine methyltransferase biochemical genetics: human lymphocyte activity

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209372

7 January 2021

Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209372

7 January 2021

Thiopurine S-methyltransferase pharmacogenetics: chaperone protein association and allozyme degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209372

7 January 2021

Inheritance and drug response

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209372

7 January 2021

Pharmacogenetics: inherited variation in amino acid sequence and altered protein quantity

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209372

7 January 2021

Pharmacogenomics: bench to bedside

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209372

7 January 2021

Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209372

7 January 2021

Posttranslational quality control: folding, refolding, and degrading proteins.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209372

7 January 2021

Human kidney thiopurine methyltransferase. Purification and biochemical properties.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209372

7 January 2021

Thiopurine methyltransferase polymorphic tandem repeat: genotype-phenotype correlation analysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209372

7 January 2021

Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209372

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209372

1 reference

Dimensions Publication ID

14 August 2017

1012498611

0 references

1 reference