(Q33384661)

26 July 2017

title

The use of clinical irrelevance criteria in covariate model building with application to dofetilide pharmacokinetic data (English)

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26 July 2017

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6

Mats O Karlsson

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26 July 2017

Karin Tunblad

1

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26 July 2017

Lars Lindbom

2

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26 July 2017

Lynn McFadyen

3

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26 July 2017

E Niclas Jonsson

4

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26 July 2017

Scott Marshall

5

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26 July 2017

publication date

1 October 2008

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Journal of Pharmacokinetics and Pharmacodynamics

26 July 2017

published in

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26 July 2017

volume

35

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26 July 2017

issue

5

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26 July 2017

page(s)

503-526

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Pharmacokinetic and pharmacodynamic effects of UK-68,798, a new potential class III antiarrhythmic drug

26 July 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10928-008-9099-Z

A dose-ranging study of UK-68,798, a novel class III anti-arrhythmic agent, in normal volunteers

21 January 2018

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Crossref

https://api.crossref.org/works/10.1007%2FS10928-008-9099-Z

Comparison of stepwise covariate model building strategies in population pharmacokinetic-pharmacodynamic analysis

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10928-008-9099-Z

Measurement of the class III antidysrhythmic drug, UK-68,798, in plasma by radioimmunoassay

21 January 2018

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12 December 2020

UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells.

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12 December 2020

Intravenous dofetilide, a class III antiarrhythmic agent, for the termination of sustained atrial fibrillation or flutter. Intravenous Dofetilide Investigators

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12 December 2020

Pharmacokinetics and metabolism of dofetilide in mouse, rat, dog and man

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12 December 2020

PsN-Toolkit--a collection of computer intensive statistical methods for non-linear mixed effect modeling using NONMEM.

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12 December 2020

Significance of metabolism in the disposition and action of the antidysrhythmic drug, dofetilide. In vitro studies and correlation with in vivo data.

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12 December 2020

Efficacy and safety of a new selective class III antiarrhythmic agent dofetilide in paroxysmal atrial fibrillation or atrial flutter

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12 December 2020

Pharmacodynamics and Pharmacokinetics of the Class III Antiarrhythmic Agent Dofetilide (UK-68,798) in Humans

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12 December 2020

Estimation of population characteristics of pharmacokinetic parameters from routine clinical data

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12 December 2020

Population modelling in drug development

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12 December 2020

Pharmacokinetic and pharmacodynamic modeling of the effects of oral and intravenous administrations of dofetilide on ventricular repolarization*

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12 December 2020

Power, selection bias and predictive performance of the Population Pharmacokinetic Covariate Model

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12 December 2020

Xpose--an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM

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12 December 2020

Efficacy and safety of intravenously administered dofetilide in acute termination of atrial fibrillation and flutter: a multicenter, randomized, double-blind, placebo-controlled trial. Danish Dofetilide in Atrial Fibrillation and Flutter Study Group

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12 December 2020

A three-step approach combining Bayesian regression and NONMEM population analysis: application to midazolam.

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12 December 2020

Prediction of creatinine clearance from serum creatinine

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12 December 2020

Efficient screening of covariates in population models using Wald's approximation to the likelihood ratio test

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12 December 2020

The pharmacokinetics and pharmacodynamics of oral dofetilide after twice daily and three times daily dosing

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12 December 2020

Effect of cimetidine and ranitidine on pharmacokinetics and pharmacodynamics of a single dose of dofetilide

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12 December 2020

Building population pharmacokineticpharmacodynamic models. I. Models for covariate effects

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12 December 2020

Automated covariate model building within NONMEM.

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12 December 2020

Dofetilide: a new pure class III antiarrhythmic agent

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12 December 2020

10.1007/S10928-008-9099-Z

Identifiers

DOI

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Dimensions Publication ID

26 July 2017

1023361617

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