(Q33389864)

26 July 2017

title

The genomic analysis of lactic acidosis and acidosis response in human cancers (English)

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26 July 2017

1 reference

Julia Ling-Yu Chen

1

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26 July 2017

Joseph E Lucas

2

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26 July 2017

Thies Schroeder

3

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26 July 2017

Seiichi Mori

4

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26 July 2017

Jianli Wu

5

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26 July 2017

Joseph Nevins

6

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26 July 2017

Mark Dewhirst

7

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26 July 2017

Mike West

8

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26 July 2017

Jen-Tsan Chi

9

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26 July 2017

publication date

5 December 2008

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26 July 2017

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26 July 2017

volume

4

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26 July 2017

issue

12

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26 July 2017

page(s)

e1000293

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Creative Commons Attribution 4.0 International

26 July 2017

copyright license

start time

5 December 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Oncogenic pathway signatures in human cancers as a guide to targeted therapies

28 July 2018

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28 July 2018

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28 July 2018

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An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival

28 July 2018

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28 July 2018

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28 July 2018

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A unique pathway of cardiac myocyte death caused by hypoxia-acidosis.

28 July 2018

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Akt stimulates aerobic glycolysis in cancer cells

28 July 2018

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Acidosis impairs insulin receptor substrate-1-associated phosphoinositide 3-kinase signaling in muscle cells: consequences on proteolysis

28 July 2018

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Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds

28 July 2018

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A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer

28 July 2018

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28 July 2018

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

28 July 2018

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Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism

28 July 2018

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HIF-1 and tumor progression: pathophysiology and therapeutics

28 July 2018

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Hypoxia--a key regulatory factor in tumour growth

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585811

Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

28 July 2018

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Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

28 July 2018

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Mitochondrion as a novel target of anticancer chemotherapy

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585811

Intracellular pH regulation in a nonmalignant and a derived malignant human breast cell line

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585811

Cluster analysis and display of genome-wide expression patterns

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585811

Tumor microenvironmental physiology and its implications for radiation oncology

28 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000293

Why do cancers have high aerobic glycolysis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000293

HIF activation by pH-dependent nucleolar sequestration of VHL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000293

Lactate modulates gene expression in human mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000293

Genome-wide gene expression profiling reveals renal genes regulated during metabolic acidosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000293

A microenvironmental model of carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000293

Influence of oxygen concentration and pH on expression of hypoxia induced genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000293

Hypoxia induced expression of endogenous markers in vitro is highly influenced by pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000293

GATHER: a systems approach to interpreting genomic signatures

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000293

Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000293

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000293

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000293

The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000293

Lactate: mirror and motor of tumor malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000293

Transcriptional response to hypoxia in human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000293

Carbonic anhydrase IX expression and tumor oxygenation status do not correlate at the microregional level in locally advanced cancers of the uterine cervix

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000293

Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585811

Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585811

Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585811

Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585811

Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation

10 December 2018

1 reference

12 December 2020

Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells

1 reference

12 December 2020

Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells

1 reference

12 December 2020

Correlation of high lactate levels in human cervical cancer with incidence of metastasis

1 reference

12 December 2020

Tumor pH: implications for treatment and novel drug design

1 reference

12 December 2020

High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers

1 reference

12 December 2020

10.1371/JOURNAL.PGEN.1000293

Identifiers

DOI

1 reference

26 July 2017

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26 July 2017

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