(Q33408783)

26 July 2017

Disease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates (English)

1 reference

26 July 2017

Elizabeth M H Tank

1

1 reference

PubMed ID

19214209

26 July 2017

Heather L True

series ordinal

2

1 reference

26 July 2017

13 February 2009

1 reference

26 July 2017

1 reference

26 July 2017

5

1 reference

26 July 2017

2

1 reference

26 July 2017

e1000382

1 reference

Creative Commons Attribution 4.0 International

26 July 2017

start time

13 February 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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21 June 2018

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The proteasome in Alzheimer's disease and Parkinson's disease: lessons from ubiquitin B+1.

21 June 2018

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21 June 2018

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Disease-specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brain

21 June 2018

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The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

21 June 2018

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Monitoring the ubiquitin/proteasome system in conformational diseases

21 June 2018

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Yeast [PSI+] Prion Aggregates Are Formed by Small Sup35 Polymers Fragmented by Hsp104

21 June 2018

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Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate

21 June 2018

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Analysis of prion factors in yeast

21 June 2018

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Toxic proteins in neurodegenerative disease

21 June 2018

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A yeast prion provides a mechanism for genetic variation and phenotypic diversity

21 June 2018

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Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.

21 June 2018

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Molecular misreading in non-neuronal cells.

21 June 2018

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Molecular misreading. A new type of transcript mutation in gerontology.

21 June 2018

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Assembly and preferential localization of Nup116p on the cytoplasmic face of the nuclear pore complex by interaction with Nup82p

21 June 2018

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 June 2018

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Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

21 June 2018

1 reference

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Recognition of the polyubiquitin proteolytic signal

21 June 2018

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CLN3 expression is sufficient to restore G1-to-S-phase progression in Saccharomyces cerevisiae mutants defective in translation initiation factor eIF4E.

21 June 2018

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The ubiquitin-proteasome pathway and pathogenesis of human diseases

21 June 2018

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Overexpression of the SUP45 gene encoding a Sup35p-binding protein inhibits the induction of the de novo appearance of the [PSI+] prion

21 June 2018

1 reference

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Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients

21 June 2018

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21 June 2018

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In vivo disassembly of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the proteasome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

The N-end rule pathway of protein degradation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

Genesis and variability of [PSI] prion factors in Saccharomyces cerevisiae.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

The multiubiquitin-chain-binding protein Mcb1 is a component of the 26S proteasome in Saccharomyces cerevisiae and plays a nonessential, substrate-specific role in protein turnover.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

Involvement of the molecular chaperone Ydj1 in the ubiquitin-dependent degradation of short-lived and abnormal proteins in Saccharomyces cerevisiae

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

Support for the prion hypothesis for inheritance of a phenotypic trait in yeast

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

Surface hydrophobic residues of multiubiquitin chains essential for proteolytic targeting

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

Single amino-acid replacement is responsible for the stabilization of ornithine decarboxylase in HMOA cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

The SUP35 omnipotent suppressor gene is involved in the maintenance of the non-Mendelian determinant [psi+] in the yeast Saccharomyces cerevisiae.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+]

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

Toxic Amino Acids: Their Action as Antimetabolites

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

Recent advances in the biochemistry of polyamines in eukaryotes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

The yeast ubiquitin genes: a family of natural gene fusions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

In vivo half-life of a protein is a function of its amino-terminal residue

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

Prevention of rapid intracellular degradation of ODC by a carboxyl-terminal truncation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

Expression of the yeast UB14 gene increases in response to DNA-damaging agents and in meiosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

Interaction of the yeast omnipotent suppressors SUP1(SUP45) and SUP2(SUP35) with non-mendelian factors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

Dosage-dependent translational suppression in yeast Saccharomyces cerevisiae

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

The ubiquitin-conjugation system

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

Ubiquitin as a degradation signal

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

UCHL1 is a Parkinson's disease susceptibility gene.

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000382

Mutations in RNA: a first example of molecular misreading in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000382

Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000382

Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000382

Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000382

Accumulation of aberrant ubiquitin induces aggregate formation and cell death in polyglutamine diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000382

Ubiquitin-independent mechanisms of mouse ornithine decarboxylase degradation are conserved between mammalian and fungal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000382

Distinct functional surface regions on ubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000382

Modulation of prion-dependent polyglutamine aggregation and toxicity by chaperone proteins in the yeast model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000382

Pleiotropic effects of Ubp6 loss on drug sensitivities and yeast prion are due to depletion of the free ubiquitin pool

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000382

Specificity of prion assembly in vivo. [PSI+] and [PIN+] form separate structures in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000382

Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

PRE2, highly homologous to the human major histocompatibility complex-linked RING10 gene, codes for a yeast proteasome subunit necessary for chrymotryptic activity and degradation of ubiquitinated proteins.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2633047

Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits

31 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000382

Ubiquitin, cellular inclusions and their role in neurodegeneration

21 January 2018

1 reference

12 December 2020

Effects of ubiquitin system alterations on the formation and loss of a yeast prion

1 reference

12 December 2020

Novel frameshift mutations near short simple repeats

1 reference

12 December 2020

Deletion analysis of the SUP35 gene of the yeast Saccharomyces cerevisiae reveals two non-overlapping functional regions in the encoded protein

1 reference

12 December 2020

10.1371/JOURNAL.PGEN.1000382

Identifiers

DOI

1 reference

26 July 2017

1 reference

26 July 2017

1 reference

PubMed ID

19214209