(Q33418187)

26 July 2017

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity (English)

1 reference

26 July 2017

Chudi O Ndubaku

22

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Brad E Sleebs

object named as

Brad E Sleebs

27

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Brian J. Smith

object named as

Brian J Smith

28

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Hans E Purkey

24

object named as

Hans E Purkey

1 reference

26 July 2017

Zhi-Fu Tao

1

1 reference

26 July 2017

Lisa Hasvold

2

1 reference

26 July 2017

Le Wang

3

1 reference

26 July 2017

Xilu Wang

4

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26 July 2017

Andrew M Petros

5

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26 July 2017

Chang H Park

6

1 reference

26 July 2017

Erwin R Boghaert

7

1 reference

26 July 2017

Nathaniel D Catron

8

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26 July 2017

Jun Chen

9

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26 July 2017

Peter M Colman

10

1 reference

26 July 2017

Peter E Czabotar

11

1 reference

26 July 2017

Kurt Deshayes

12

1 reference

26 July 2017

Wayne J Fairbrother

13

1 reference

26 July 2017

John A Flygare

14

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26 July 2017

Sarah G Hymowitz

15

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26 July 2017

Sha Jin

16

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26 July 2017

Russell A Judge

17

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26 July 2017

Michael F T Koehler

18

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26 July 2017

Peter J Kovar

19

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26 July 2017

Guillaume Lessene

20

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26 July 2017

Michael J Mitten

21

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26 July 2017

Paul Nimmer

23

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26 July 2017

Anatol Oleksijew

25

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26 July 2017

Darren C Phillips

26

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26 July 2017

Morey L Smith

29

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26 July 2017

Stephen K Tahir

30

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26 July 2017

Keith G Watson

31

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26 July 2017

Yu Xiao

32

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26 July 2017

John Xue

33

1 reference

26 July 2017

Haichao Zhang

34

1 reference

26 July 2017

Kerry Zobel

35

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26 July 2017

Saul H Rosenberg

36

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26 July 2017

Chris Tse

37

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26 July 2017

Joel D Leverson

38

1 reference

26 July 2017

Steven W Elmore

39

1 reference

26 July 2017

Andrew J Souers

40

1 reference

26 July 2017

26 August 2014

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ACS Medicinal Chemistry Letters

26 July 2017

1 reference

26 July 2017

5

1 reference

26 July 2017

1088-1093

1 reference

26 July 2017

10

1 reference

Structure-Guided Rescaffolding of Selective Antagonists of BCL-X L

26 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

Structure-guided design of a selective BCL-X(L) inhibitor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

Navitoclax (ABT-263) reduces Bcl-x(L)-mediated chemoresistance in ovarian cancer models

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

Fluorine in pharmaceuticals: looking beyond intuition

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

Programmed anuclear cell death delimits platelet life span.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

The Bcl-2 apoptotic switch in cancer development and therapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

An informatics approach identifying markers of chemosensitivity in human cancer cell lines.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

21 June 2018

The Hallmarks of Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

Discovering high-affinity ligands for proteins: SAR by NMR

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

Bcl-2 family proteins are essential for platelet survival.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190639

31 October 2018

Identifiers

DOI

10.1021/ML5001867

1 reference

26 July 2017

1 reference

26 July 2017

1 reference