(Q33471412)

27 July 2017

title

Selective processing and metabolism of disease-causing mutant prion proteins (English)

1 reference

27 July 2017

0 references

Ramanujan Shankar Hegde

series ordinal

2

1 reference

27 July 2017

Aarthi Ashok

1

1 reference

27 July 2017

language of work or name

1 reference

19 June 2009

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27 July 2017

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27 July 2017

volume

5

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27 July 2017

issue

6

1 reference

27 July 2017

page(s)

e1000479

1 reference

Creative Commons CC0 License

27 July 2017

copyright license

start time

19 June 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

cites work

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21 June 2018

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The prion's elusive reason for being

21 June 2018

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Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

21 June 2018

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Retrotranslocation of prion proteins from the endoplasmic reticulum by preventing GPI signal transamidation

21 June 2018

1 reference

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Protein quality control in the early secretory pathway

21 June 2018

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Autophagy in the Pathogenesis of Disease

21 June 2018

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Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans

21 June 2018

1 reference

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Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway

21 June 2018

1 reference

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Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein

21 June 2018

1 reference

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Potential compensatory responses through autophagic/lysosomal pathways in neurodegenerative diseases

21 June 2018

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Protein misfolding and human disease

21 June 2018

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Monitoring chaperone engagement of substrates in the endoplasmic reticulum of live cells

21 June 2018

1 reference

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Detergent-resistant membrane domains but not the proteasome are involved in the misfolding of a PrP mutant retained in the endoplasmic reticulum

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691595

Protein degradation and aging

21 June 2018

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Pathogenic mutations located in the hydrophobic core of the prion protein interfere with folding and attachment of the glycosylphosphatidylinositol anchor.

21 June 2018

1 reference

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Protection from cytosolic prion protein toxicity by modulation of protein translocation

21 June 2018

1 reference

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Misfolding of the prion protein at the plasma membrane induces endocytosis, intracellular retention and degradation

21 June 2018

1 reference

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Doxycycline and protein folding agents rescue the abnormal phenotype of familial CJD H187R in a cell model

21 June 2018

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Scrapie-like prion protein accumulates in aggresomes of cyclosporin A-treated cells.

21 June 2018

1 reference

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Mutations of the prion protein gene phenotypic spectrum

21 June 2018

1 reference

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The neuropathogenic contributions of lysosomal dysfunction

21 June 2018

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Secretory pathway quality control operating in Golgi, plasmalemmal, and endosomal systems

21 June 2018

1 reference

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Cellular phenotyping of secretory and nuclear prion proteins associated with inherited prion diseases

21 June 2018

1 reference

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Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation

21 June 2018

1 reference

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Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691595

Mutant prion proteins are partially retained in the endoplasmic reticulum

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691595

Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691595

Prion protein with an E200K mutation displays properties similar to those of the cellular isoform PrP(C).

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691595

Most pathogenic mutations do not alter the membrane topology of the prion protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691595

Effect of the E200K mutation on prion protein metabolism. Comparative study of a cell model and human brain

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691595

Transmissible and genetic prion diseases share a common pathway of neurodegeneration

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691595

Yeast mutants affecting possible quality control of plasma membrane proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691595

A transmembrane form of the prion protein in neurodegenerative disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691595

Aggregation as a determinant of protein fate in post-Golgi compartments: role of the luminal domain of furin in lysosomal targeting

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691595

A pathway for targeting soluble misfolded proteins to the yeast vacuole

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691595

Two mutant prion proteins expressed in cultured cells acquire biochemical properties reminiscent of the scrapie isoform.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691595

Targeting of the yeast plasma membrane [H+]ATPase: a novel gene AST1 prevents mislocalization of mutant ATPase to the vacuole

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691595

Building a multichain receptor: synthesis, degradation, and assembly of the T-cell antigen receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691595

Synthesis and trafficking of prion proteins in cultured cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691595

Lysosomes as key organelles in the pathogenesis of prion encephalopathies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691595

Evidence for synthesis of scrapie prion proteins in the endocytic pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691595

Signal sequences control gating of the protein translocation channel in a substrate-specific manner

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000479

Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000479

Expression of wild-type and V210I mutant prion protein in human neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000479

Involvement of the endosomal-lysosomal system correlates with regional pathology in Creutzfeldt-Jakob disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000479

Up-regulation of cathepsin B and cathepsin L activities in scrapie-infected mouse Neuro2a cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000479

The abnormal isoform of the prion protein accumulates in late-endosome-like organelles in scrapie-infected mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000479

Recognition of lumenal prion protein aggregates by post-ER quality control mechanisms is mediated by the preoctarepeat region of PrP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000479

The Metabolism and Imaging in Live Cells of the Bovine Prion Protein in Its Native Form or Carrying Single Amino Acid Substitutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000479

Aggresome formation by mutant prion proteins: the unfolding role of proteasomes in familial prion disorders

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691595

The Chaperone Protein BiP Binds to a Mutant Prion Protein and Mediates Its Degradation by the Proteasome

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19543376

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Prion Protein Aggregation Reverted by Low Temperature in Transfected Cells Carrying a Prion Protein Gene Mutation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19543376

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Coexpression of Wild-type and Mutant Prion Proteins Alters Their Cellular Localization and Partitioning into Detergent-resistant Membranes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19543376

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PPAT.1000479

1 reference

27 July 2017

1 reference

27 July 2017

1 reference