(Q33489931)

English

Trimetrexate. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of Pneumocystis carinii pneumonia

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

1 reference

Europe PubMed Central

Trimetrexate. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of Pneumocystis carinii pneumonia (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Pneumocystis carinii

object named as

Pneumocystis carinii

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

author name string

Fulton B

1

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Wagstaff AJ

2

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

McTavish D

3

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

publication date

1 April 1995

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

49

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

563-576

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Clindamycin/primaquine versus trimethoprim-sulfamethoxazole as primary therapy for Pneumocystis carinii pneumonia in AIDS: a randomized, double-blind pilot trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of trimetrexate administered by five-day continuous infusion to patients with advanced cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy of trimetrexate, a potent lipid-soluble antifolate, in the treatment of rodent Pneumocystis carinii pneumonia

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of trimethoprim, paracetamol and cimetidine on trimetrexate metabolism by rat perfused isolated livers

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activities of antifolate, antiviral, and other drugs in an immunosuppressed rat model of Pneumocystis carinii pneumonia

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pneumocystis carinii dihydrofolate reductase used to screen potential antipneumocystis drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I trial of trimetrexate glucuronate on a five-day bolus schedule: clinical pharmacology and pharmacodynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trimetrexate-leucovorin dosage evaluation study for treatment of Pneumocystis carinii pneumonia

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The fungal nature of Pneumocystis

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of atovaquone (566C80) with trimethoprim-sulfamethoxazole to treat Pneumocystis carinii pneumonia in patients with AIDS

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The challenge of Pneumocystis carinii culture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Eflornithine versus cotrimoxazole in the treatment of Pneumocystis carinii pneumonia in AIDS patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of leucovorin protection from variety of antifolates in human lymphoid cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase I trial of trimetrexate glucuronate (NSC 352122) given every 3 weeks: clinical pharmacology and pharmacodynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leucovorin protection against repeated daily dose toxicity of trimetrexate in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I and clinical pharmacology study of trimetrexate administered weekly for three weeks

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacokinetics and pharmacology of trimetrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypersensitivity reactions to trimetrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity of antifolates against Pneumocystis carinii dihydrofolate reductase and identification of a potent new agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioavailability of oral trimetrexate in patients with acquired immunodeficiency syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of de novo folate synthesis in Pneumocystis carinii and Toxoplasma gondii: potential for screening therapeutic agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I studies with trimetrexate: clinical pharmacology, analytical methodology, and pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trimetrexate for the treatment of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I clinical and pharmacokinetic study of trimetrexate using a daily x5 schedule

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pediatric phase I trial and pharmacokinetic study of trimetrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in a rat model of infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical Science Review: Update on Trimetrexate, a Folate Antagonist with Antineoplastic and Antiprotozoal Properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacology of trimetrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase I and pharmacokinetic study of trimetrexate using a 24-hour continuous-injection schedule

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trimetrexate with leucovorin versus trimethoprim-sulfamethoxazole for moderate to severe episodes of Pneumocystis carinii pneumonia in patients with AIDS: a prospective, controlled multicenter investigation of the AIDS Clinical Trials Group Protocol

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and adverse effects of 20-mg/kg/day trimethoprim and 100-mg/kg/day sulfamethoxazole in healthy adult subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase I study of trimetrexate (NSC 352122) administered by 5-day continuous intravenous infusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pneumocystis carinii pneumonia: therapy and prophylaxis

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral therapy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A controlled trial of trimethoprim-sulfamethoxazole versus trimethoprim-dapsone

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical pharmacology of the lipophilic antifolate, trimetrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic optimisation in the treatment of Pneumocystis carinii pneumonia

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leucovorin antagonizes the effects of trimetrexate on mouse hemopoietic progenitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trimetrexate efficacy and pharmacokinetics during treatment of refractory Pneumocystis carinii pneumonia in an infant with severe combined immunodeficiency disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment and prophylaxis of Pneumocystis carinii pneumonia in AIDS patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic study of trimetrexate in combination with cisplatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent advances in the diagnosis, treatment, and prevention of Pneumocystis carinii pneumonia

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of trimetrexate glucuronate in infants with AIDS and Pneumocystis carinii pneumonia

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I studies of trimetrexate using single and weekly dose schedules

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trimethoprim-sulfamethoxazole compared with pentamidine for treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A prospective, noncrossover study

1 reference

https://pubmed.ncbi.nlm.nih.gov/7789290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2165/00003495-199549040-00007

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q33489931&oldid=2195409731"