(Q33523009)

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The Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks.

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20062519%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

The Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20062519%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Caenorhabditis elegans

0 references

Serine/threonine-protein kinase ATM CELE_Y48G1BL.2

1 reference

GOA release 2020-03-11

Werner syndrome

1 reference

based on heuristic

inferred from title

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20062519%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

5

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20062519%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

author name string

Se-Jin Lee

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20062519%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Moonjung Hyun

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20062519%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Byungchan Ahn

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20062519%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

publication date

8 January 2010

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20062519%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20062519%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20062519%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20062519%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

e1000801

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20062519%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

copyright license

Creative Commons Attribution 4.0 International

8 January 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Functional dissection of Caenorhabditis elegans CLK-2/TEL2 cell cycle defects during embryogenesis and germline development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

DNA helicases Sgs1 and BLM promote DNA double-strand break resection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Germline survival and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Biochemical characterization of the WRN-1 RecQ helicase of Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Human CtIP promotes DNA end resection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Werner syndrome protein: functions in the response to DNA damage and replication stress in S-phase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Controls of germline stem cells, entry into meiosis, and the sperm/oocyte decision in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Developmental modulation of nonhomologous end joining in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Cellular analyses of the mitotic region in the Caenorhabditis elegans adult germ line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Accumulation of Werner protein at DNA double-strand breaks in human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Current advances in unraveling the function of the Werner syndrome protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

chk-1 is an essential gene and is required for an S-M checkpoint during early embryogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Death and more: DNA damage response pathways in the nematode C. elegans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Preferential binding of ATR protein to UV-damaged DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

ATR and ATRIP: partners in checkpoint signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Nuclear reorganization and homologous chromosome pairing during meiotic prophase require C. elegans chk-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Unwinding the molecular basis of the Werner syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Specific interference by ingested dsRNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

GLD-1, a cytoplasmic protein essential for oocyte differentiation, shows stage- and sex-specific expression during Caenorhabditis elegans germline development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Positional cloning of the Werner's syndrome gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

The genetics of Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

Parental DNA strands segregate randomly during embryonic development of Caenorhabditis elegans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

14 July 2018

A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000801

21 January 2018

A Werner syndrome protein homolog affects C. elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000801

21 January 2018

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000801

21 January 2018

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000801

21 January 2018

The nucleotide excision repair pathway is required for UV-C-induced apoptosis in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000801

21 January 2018

The efficiency of RNA interference in Bursaphelenchus xylophilus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

31 October 2018

The G2-phase decatenation checkpoint is defective in Werner syndrome cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791846

31 October 2018

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/20062519

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PGEN.1000801

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20062519%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20062519%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20062519%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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