(Q33537987)

27 July 2017

In vitro metabolic and mitogenic signaling of insulin glargine and its metabolites (English)

1 reference

27 July 2017

1 reference

1 reference

Günter Müller

2

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author name string

Mark R Sommerfeld

1

1 reference

27 July 2017

Georg Tschank

3

1 reference

27 July 2017

Gerhard Seipke

4

1 reference

27 July 2017

Paul Habermann

5

1 reference

27 July 2017

Roland Kurrle

6

1 reference

27 July 2017

Norbert Tennagels

7

1 reference

27 July 2017

language of work or name

English

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publication date

4 March 2010

1 reference

27 July 2017

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27 July 2017

5

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27 July 2017

3

1 reference

27 July 2017

e9540

1 reference

Creative Commons Attribution 4.0 International

27 July 2017

start time

4 March 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Growth effects of insulin and insulin analogues

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Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells

21 June 2018

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Identification of a novel AS160 splice variant that regulates GLUT4 translocation and glucose-uptake in rat muscle cells

21 June 2018

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Scintillation proximity assay (SPA) technology to study biomolecular interactions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

Mitogenic effect of the insulin analogue glargine in malignant cells in comparison with insulin and IGF-I.

21 June 2018

1 reference

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Insulin glargine and receptor-mediated signalling: clinical implications in treating type 2 diabetes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

pI-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity

21 June 2018

1 reference

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Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1.

21 June 2018

1 reference

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Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

Free insulin-like growth factors -- measurements and relationships to growth hormone secretion and glucose homeostasis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

IGFs and IGFBPs: role in health and disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

Structural biology of insulin and IGF1 receptors: implications for drug design

21 June 2018

1 reference

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An overview of insulin glargine

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

21 June 2018

1 reference

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Insulin glargine: a new basal insulin

21 June 2018

1 reference

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Insulin analogs with improved pharmacokinetic profiles

21 June 2018

1 reference

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Binding of phenol to R6 insulin hexamers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.

21 June 2018

1 reference

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Long-acting insulin analogs.

21 June 2018

1 reference

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Structure-activity relationship of synthetic phosphoinositolglycans mimicking metabolic insulin action

21 June 2018

1 reference

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Sustained signalling from the insulin receptor after stimulation with insulin analogues exhibiting increased mitogenic potency

21 June 2018

1 reference

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Ligand-binding properties of the two isoforms of the human insulin receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

The sulfonylurea drug, glimepiride, stimulates glucose transport, glucose transporter translocation, and dephosphorylation in insulin-resistant rat adipocytes in vitro

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

Insulin receptors: binding kinetics and structure-function relationship of insulin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

The structure of 2Zn pig insulin crystals at 1.5 A resolution

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

Monomeric insulins and their experimental and clinical implications

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

The bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptake

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

Does diabetes therapy influence the risk of cancer?

21 June 2018

1 reference

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Insulin-responsiveness of tumor growth

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

Analysis of signaling pathways related to cell proliferation stimulated by insulin analogs in human mammary epithelial cell lines.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

Fluctuation and reproducibility of exposure and effect of insulin glargine in healthy subjects

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

Differential gene expression of insulin receptor isoforms A and B and insulin receptor substrates 1, 2 and 3 in rat tissues: modulation by aging and differentiation in rat adipose tissue

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetes

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

Biotransformation of insulin glargine after subcutaneous injection in healthy subjects

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

No evidence for accumulation of insulin glargine (LANTUS): a multiple injection study in patients with Type 1 diabetes

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

Evaluation of the carcinogenic potential of insulin glargine (LANTUS) in rats and mice.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832019

Insulin analogues: action profiles beyond glycaemic control

31 October 2018

1 reference

12 December 2020

Modifications in the B10 and B26-30 regions of the B chain of human insulin alter affinity for the human IGF-I receptor more than for the insulin receptor

1 reference

12 December 2020

Glargine blood biotransformation: in vitro appraisal with human insulin immunoassay

1 reference

12 December 2020

Labeling of insulin with non-radioactive 127I and application to incorporation of radioactive 125I for use in receptor-binding experiments by high-performance liquid chromatography

1 reference

12 December 2020

A novel autocrine loop involving IGF-II and the insulin receptor isoform-A stimulates growth of thyroid cancer

1 reference

12 December 2020

Fluctuation of serum basal insulin levels following single and multiple dosing of insulin glargine

1 reference

12 December 2020

Insulin Glargine: a review 8 years after its introduction

1 reference

12 December 2020

Specificity of insulin and insulin-like growth factor I receptors investigated using chimeric mini-receptors. Role of C-terminal of receptor alpha subunit

1 reference

12 December 2020

Insulin receptor activation by IGF-II in breast cancers: evidence for a new autocrine/paracrine mechanism

1 reference

12 December 2020

The role of insulin receptors and IGF-I receptors in cancer and other diseases

1 reference

12 December 2020

Comparison of the mitogenic potency of regular human insulin and its analogue glargine in normal and transformed human breast epithelial cells

1 reference

12 December 2020

Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use

1 reference

12 December 2020

Alanine scanning mutagenesis of insulin

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0009540

Identifiers

DOI

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27 July 2017

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27 July 2017

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