(Q33547235)

28 July 2017

title

Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen (English)

1 reference

28 July 2017

Lori M Neal

3

0 references

Nicholas J. Mantis

object named as

Nicholas J Mantis

5

0 references

author name string

Paul G Wahome

1

1 reference

28 July 2017

Yan Bai

2

1 reference

28 July 2017

Jon D Robertus

4

1 reference

28 July 2017

language of work or name

1 reference

27 March 2010

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28 July 2017

number of pages

11

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inferred from page(s)

published in

Toxicon

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28 July 2017

volume

56

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28 July 2017

issue

3

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28 July 2017

page(s)

313-323

1 reference

A monoclonal immunoglobulin G antibody directed against an immunodominant linear epitope on the ricin A chain confers systemic and mucosal immunity to ricin

28 July 2017

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21 June 2018

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Promiscuous aggregate-based inhibitors promote enzyme unfolding

21 June 2018

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Novel cell-based method to detect Shiga toxin 2 from Escherichia coli O157:H7 and inhibitors of toxin activity

21 June 2018

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The X-ray structure of ricin A chain with a novel inhibitor

21 June 2018

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Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening

21 June 2018

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Protective effects of anti-ricin A-chain RNA aptamer against ricin toxicity

21 June 2018

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High-throughput screening of a 100,000-compound library for inhibitors of influenza A virus (H3N2).

21 June 2018

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Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression

21 June 2018

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Pathogenesis and treatment of Shiga toxin-producing Escherichia coli infections

21 June 2018

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Identification and characterization of small molecules that inhibit intracellular toxin transport

21 June 2018

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Evidence for widespread epithelial damage and coincident production of monocyte chemotactic protein 1 in a murine model of intestinal ricin intoxication

21 June 2018

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A critical assessment of docking programs and scoring functions

21 June 2018

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A cell-based luminescence assay is effective for high-throughput screening of potential influenza antivirals

21 June 2018

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Statistical practice in high-throughput screening data analysis

21 June 2018

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Ricin induces IL-8 secretion from human monocyte/macrophages by activating the p38 MAP kinase pathway.

21 June 2018

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Ricin poisoning: a comprehensive review

21 June 2018

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Virtual Computational Chemistry Laboratory – Design and Description

21 June 2018

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A quantitative and highly sensitive luciferase-based assay for bacterial toxins that inhibit protein synthesis

21 June 2018

1 reference

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Vaccines against the category B toxins: Staphylococcal enterotoxin B, epsilon toxin and ricin.

21 June 2018

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Virtual screening of chemical libraries

21 June 2018

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Antitoxins: novel strategies to target agents of bioterrorism

21 June 2018

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The structure of ribosome inactivating proteins

21 June 2018

1 reference

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Investigation of a ricin-containing envelope at a postal facility - South Carolina, 2003

21 June 2018

1 reference

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Identification and Prediction of Promiscuous Aggregating Inhibitors among Known Drugs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

Pathways followed by ricin and Shiga toxin into cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

Drug-like properties and the causes of poor solubility and poor permeability

21 June 2018

1 reference

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Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical perspectives

21 June 2018

1 reference

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 June 2018

1 reference

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Biological and chemical terrorism: strategic plan for preparedness and response - recommendations of the CDC strategic planning workgroup

21 June 2018

1 reference

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Ricin A-chain: kinetics, mechanism, and RNA stem-loop inhibitors

21 June 2018

1 reference

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Development and validation of a genetic algorithm for flexible docking

21 June 2018

1 reference

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Structure-based identification of a ricin inhibitor

21 June 2018

1 reference

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Morphology of ricin and abrin exposed endothelial cells is consistent with apoptotic cell death

21 June 2018

1 reference

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Structure of recombinant ricin A chain at 2.3 A

21 June 2018

1 reference

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X-ray structure of recombinant ricin A-chain at 1.8 A resolution

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

Crystal structure of the holotoxin from Shigella dysenteriae at 2.5 A resolution

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

Georgi Markov--death in a pellet.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

Thiostrepton, an Inhibitor of 50 S Ribosome Subunit Function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

Nucleotide sequence of the Shiga-like toxin genes of Escherichia coli

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

RNA N-glycosidase activity of ricin A-chain. Mechanism of action of the toxic lectin ricin on eukaryotic ribosomes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

Cloning and sequencing of the genes for Shiga toxin from Shigella dysenteriae type 1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

Role of glutamic acid 177 of the ricin toxin A chain in enzymatic inactivation of ribosomes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

The chemistry and biology of the immunomodulating agent gliotoxin and related epipolythiodioxopiperazines

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

21 June 2018

Castor bean intoxication

1 reference

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Role of arginine 180 and glutamic acid 177 of ricin toxin A chain in enzymatic inactivation of ribosomes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

Structure of ricin A-chain at 2.5 A.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

Crystallographic refinement of ricin to 2.5 A

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

Brefeldin A: insights into the control of membrane traffic and organelle structure

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

X-ray analysis of substrate analogs in the ricin A-chain active site

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902711

Structural determinants of Ricinus communis agglutinin and toxin specificity for oligosaccharides

21 June 2018

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12 December 2020

Site-directed mutagenesis of ricin A-chain and implications for the mechanism of action

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12 December 2020

The three-dimensional structure of ricin at 2.8 A

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12 December 2020

Mechanism of action of ricin and related toxins on the inactivation of eukaryotic ribosomes

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12 December 2020

Structural analysis of ricin and implications for inhibitor design

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12 December 2020

THE IDENTIFICATION OF THE HISTIDINE RESIDUE AT THE ACTIVE CENTER OF CHYMOTRYPSIN

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12 December 2020

10.1016/J.TOXICON.2010.03.016

Identifiers

DOI

1 reference

28 July 2017

1 reference

28 July 2017

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