(Q33565239)

28 July 2017

title

Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents (English)

1 reference

28 July 2017

Suman Kundu

1

1 reference

28 July 2017

Keke Fan

2

1 reference

28 July 2017

Mingli Cao

3

1 reference

28 July 2017

Daniel J Lindner

4

1 reference

28 July 2017

Zhizhaung Joe Zhao

5

1 reference

28 July 2017

Ernest Borden

6

1 reference

28 July 2017

Taolin Yi

7

1 reference

28 July 2017

language of work or name

English

0 references

publication date

26 April 2010

1 reference

28 July 2017

published in

Journal of Immunology

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28 July 2017

volume

184

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28 July 2017

issue

11

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28 July 2017

page(s)

6529-6536

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Phase I Dose Escalation Study of Sodium Stibogluconate (SSG), a Protein Tyrosine Phosphatase Inhibitor, Combined with Interferon Alpha for Patients with Solid Tumors

28 July 2017

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Interferon-gamma is induced in human peripheral blood immune cells in vitro by sodium stibogluconate/interleukin-2 and mediates its antitumor activity in vivo

21 June 2018

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21 June 2018

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21 June 2018

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The role and target potential of protein tyrosine phosphatases in cancer

21 June 2018

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21 June 2018

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21 June 2018

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Efficacy of SSG and SSG/IFNalpha2 against human prostate cancer xenograft tumors in mice: a role for direct growth inhibition in SSG anti-tumor action

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Sunitinib in patients with metastatic renal cell carcinoma

21 June 2018

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Multiple targeted tyrosine kinase inhibition in the clinic: all for one or one for all?

21 June 2018

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Molecular immunological approaches to biotherapy of human cancers--a review, hypothesis and implications

21 June 2018

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Cytokine-based therapy and biochemotherapy for advanced melanoma

21 June 2018

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BAY 43-9006 inhibition of oncogenic RET mutants

21 June 2018

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Sodium stibogluconate interacts with IL-2 in anti-Renca tumor action via a T cell-dependent mechanism in connection with induction of tumor-infiltrating macrophages

21 June 2018

1 reference

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Germ-line and somatic PTPN11 mutations in human disease

21 June 2018

1 reference

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The adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activation

21 June 2018

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Abnormal Th1 cell differentiation and IFN-gamma production in T lymphocytes from motheaten viable mice mutant for Src homology 2 domain-containing protein tyrosine phosphatase-1.

21 June 2018

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Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

21 June 2018

1 reference

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Molecularly targeted therapy: have the floodgates opened?

21 June 2018

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Shedding light on immunotherapy for cancer

21 June 2018

1 reference

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Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation

21 June 2018

1 reference

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Genomic alterations in spontaneous and carcinogen-induced murine melanoma cell lines

21 June 2018

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The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

21 June 2018

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Small Molecule Regulation of Phosphatase-Dependent Cell Signaling Pathways

21 June 2018

1 reference

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PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity

21 June 2018

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Kidney cancer: the Cytokine Working Group experience (1986-2001): part I. IL-2-based clinical trials

21 June 2018

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The roles of IFN gamma in protection against tumor development and cancer immunoediting

21 June 2018

1 reference

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Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development

21 June 2018

1 reference

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Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

21 June 2018

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The molecular bases of spontaneous immunological mutations in the mouse and their homologous human diseases.

21 June 2018

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A phosphatase associated with metastasis of colorectal cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Interleukin-2 and the development of immunotherapy for the treatment of patients with cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Modulation of TCR signaling by beta1 integrins: role of the tyrosine phosphatase SHP-1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Regulation of immune responses through inhibitory receptors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Comparison of cytokine measurements using ELISA, ELISPOT and semi-quantitative RT-PCR.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

4-(Phenylamino)pyrrolopyrimidines: potent and selective, ATP site directed inhibitors of the EGF-receptor protein tyrosine kinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Selection of Successive Tumour Lines for Metastasis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Chemotherapy for leishmaniasis: biochemical mechanisms, clinical efficacy, and future strategies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Experimental models in human melanoma research: a logical perspective

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Speculations on the Role of Ultraviolet Radiation in the Development of Malignant Melanoma4

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Characterization of EBV-genome negative “null” and “T” cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non-Hodgkin lymphoma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

TCR signal transduction: opening the black box.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Toll-like receptor 4 mediates an antitumor host response induced by Salmonella choleraesuis.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Anticancer activity of sodium stibogluconate in synergy with IFNs

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049920

Surface expression of hemopoietic cell phosphatase fails to complement CD45 deficiency and inhibits TCR-mediated signal transduction in a Jurkat T cell clone

31 October 2018

1 reference

12 December 2020

Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: detection of potential HCP substrates in GM-CSF signal transduction

1 reference

12 December 2020

Local versus systemic interleukin-2: tumor formation by wild-type and B7-1-positive murine melanoma cells

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12 December 2020

Expression, purification, and crystallization of the catalytic domain of protein tyrosine phosphatase SHP-1

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12 December 2020

Vascular leak syndrome: a troublesome side effect of immunotherapy, Immunopharmacology, 39/3 (1998) 255

1 reference

12 December 2020

Synergistic antitumor effects of a combination of interferons and retinoic acid on human tumor cells in vitro and in vivo

1 reference

12 December 2020

T cells infiltrating non-Hodgkin's B cell lymphomas show altered tyrosine phosphorylation pattern even though T cell receptor/CD3-associated kinases are present

1 reference

12 December 2020

Role of gastrin and gastrin receptors on the growth of a transplantable mouse colon carcinoma (MC-26) in BALB/c mice

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.0903562

1 reference

28 July 2017

1 reference

28 July 2017

1 reference