(Q40587895)

21 September 2017

Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation (English)

1 reference

21 September 2017

1 reference

2

1 reference

21 September 2017

Alessandra Fragale

1

0 references

Bruce D. Gelb

series ordinal

4

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author name string

Jie Wu

series ordinal

3

1 reference

21 September 2017

1 March 2004

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21 September 2017

1 reference

21 September 2017

23

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21 September 2017

267-277

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21 September 2017

3

1 reference

Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression

21 September 2017

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

Noonan syndrome. An update and review for the primary pediatrician

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Requirement of SHP2 binding to Grb2-associated binder-1 for mitogen-activated protein kinase activation in response to lysophosphatidic acid and epidermal growth factor

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Regulation of the mitogen-activated protein kinase signaling pathway by SHP2.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Shp-2 tyrosine phosphatase: signaling one cell or many

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Crystal structure of the tyrosine phosphatase SHP-2

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Mapping a gene for Noonan syndrome to the long arm of chromosome 12

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

https://api.crossref.org/works/10.1002%2FHUMU.20005

1 reference

7 January 2021

PTPN11 mutations in Noonan syndrome type I: detection of recurrent mutations in exons 3 and 13.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Congenital heart diseases in children with Noonan syndrome: An expanded cardiac spectrum with high prevalence of atrioventricular canal

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Non-radioactive method to measure CD45 protein tyrosine phosphatase activity isolated directly from cells

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Phosphorylated synthetic peptides as tools for studying protein phosphatases

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

The phosphotyrosine phosphatase PTP1D, but not PTP1C, is an essential mediator of fibroblast proliferation induced by tyrosine kinase and G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Mutagenesis reveals a role for epidermal growth factor receptor extracellular subdomain IV in ligand binding

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

The SH2 tyrosine phosphatase shp2 is required for mammalian limb development.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

PTPN11 mutation in a large family with Noonan syndrome and dizygous twinning

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Altered expression of protein-tyrosine phosphatase 2C in 293 cells affects protein tyrosine phosphorylation and mitogen-activated protein kinase activation

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20005

7 January 2021

Identifiers

DOI

10.1002/HUMU.20005

1 reference

21 September 2017

1 reference

PubMed ID

14974085