(Q33569877)

28 July 2017

title

Estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysin (English)

1 reference

28 July 2017

1 reference

Zhimin Xiao

4

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author name string

Kaiwei Liang

1

1 reference

28 July 2017

Liuqing Yang

2

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28 July 2017

Chen Yin

3

1 reference

28 July 2017

Junjian Zhang

5

1 reference

28 July 2017

Yumin Liu

6

1 reference

28 July 2017

Jian Huang

7

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28 July 2017

language of work or name

English

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publication date

6 November 2009

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Journal of Biological Chemistry

28 July 2017

published in

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28 July 2017

volume

285

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28 July 2017

issue

2

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28 July 2017

page(s)

935-942

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Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome.

28 July 2017

cites work

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Amyloid-degrading enzymes as therapeutic targets in Alzheimer's disease

14 July 2018

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Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice

14 July 2018

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Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy

14 July 2018

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Estrogen receptor {beta}1 exerts antitumoral effects on SK-OV-3 ovarian cancer cells

14 July 2018

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Effects of hypoxia and oxidative stress on expression of neprilysin in human neuroblastoma cells and rat cortical neurones and astrocytes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801294

Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences

14 July 2018

1 reference

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beta-Amyloid degradation and Alzheimer's disease

14 July 2018

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RNAi-mediated silencing of estrogen receptor {alpha} in the ventromedial nucleus of hypothalamus abolishes female sexual behaviors.

14 July 2018

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Abeta-degrading enzymes: modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention

14 July 2018

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Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y.

14 July 2018

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Estrogen receptor alpha and beta immunoreactive neurons in normal adult and aged female rat hippocampus: a qualitative and quantitative study

14 July 2018

1 reference

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Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1

14 July 2018

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Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

14 July 2018

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Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes

14 July 2018

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Estrogen regulates neprilysin activity in rat brain

14 July 2018

1 reference

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Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity

14 July 2018

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Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons

14 July 2018

1 reference

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Neprilysin regulates amyloid Beta peptide levels

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801294

Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression

14 July 2018

1 reference

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Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

14 July 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

14 July 2018

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Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method

14 July 2018

1 reference

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Disruption of estrogen receptor beta gene impairs spatial learning in female mice

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801294

Neuroprotective effects of estrogen against beta-amyloid toxicity are mediated by estrogen receptors in cultured neuronal cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801294

Role of estrogen receptor beta in estrogen action

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801294

Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801294

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801294

Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801294

Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system.

14 July 2018

1 reference

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Metabolic regulation of brain Abeta by neprilysin.

14 July 2018

1 reference

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Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.051664

Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: inverse correlation with A beta levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.051664

A bipartite recombinant yeast system for the identification of subtype-selective estrogen receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.051664

Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.051664

Estrogen receptor 1 polymorphisms and risk of cognitive impairment in older women

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M109.051664

Association of the estrogen receptor alpha gene polymorphisms with sporadic Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.051664

Estrogen receptor beta gene variants are associated with increased risk of Alzheimer's disease in women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.051664

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.051664

Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.051664

Androgens regulate neprilysin expression: role in reducing beta-amyloid levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.051664

Evidence for the colocalization of estrogen receptor-beta mRNA and estrogen receptor-alpha immunoreactivity in neurons of the rat forebrain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.051664

Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801294

31 October 2018

Identifiers

DOI

10.1074/JBC.M109.051664

1 reference

28 July 2017

1 reference

28 July 2017

1 reference