(Q33570837)

28 July 2017

title

Synthetic mRNA splicing modulator compounds with in vivo antitumor activity (English)

1 reference

28 July 2017

Chandraiah Lagisetti

1

1 reference

28 July 2017

Alan Pourpak

2

1 reference

28 July 2017

Tinopiwa Goronga

3

1 reference

28 July 2017

Qin Jiang

4

1 reference

28 July 2017

Xiaoli Cui

5

1 reference

28 July 2017

Judith Hyle

6

1 reference

28 July 2017

Jill M Lahti

7

1 reference

28 July 2017

Stephan W Morris

8

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28 July 2017

Thomas R Webb

9

1 reference

28 July 2017

language of work or name

English

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publication date

1 November 2009

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Journal of Medicinal Chemistry

28 July 2017

published in

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28 July 2017

volume

52

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28 July 2017

issue

22

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28 July 2017

page(s)

6979-6990

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Antitumor compounds based on a natural product consensus pharmacophore

28 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

Extra-renal non-cerebral rhabdoid tumours

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

Neuroblastoma: biology, prognosis, and treatment

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

Solution-phase parallel synthesis of carbamates as gamma-secretase inhibitors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

MLL translocations, histone modifications and leukaemia stem-cell development

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

An efficient, inexpensive, and shelf-stable diazotransfer reagent: imidazole-1-sulfonyl azide hydrochloride

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

p27Kip1 metabolism: a fascinating labyrinth

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

A double-reporter splicing assay for determining splicing efficiency in mammalian cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

Total syntheses, fragmentation studies, and antitumor/antiproliferative activities of FR901464 and its low picomolar analogue

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

Stereoselective synthesis and anti-inflammatory activities of 6- and 7-membered dioxacycloalkanes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

Atypical teratoid rhabdoid tumors of childhood: diagnosis, treatment and challenges

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

Design of ester prodrugs to enhance oral absorption of poorly permeable compounds: challenges to the discovery scientist

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

A double reporter assay for detecting changes in the ratio of spliced and unspliced mRNA in mammalian cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

Physicochemical aspects of the enzymatic hydrolysis of carboxylic esters

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

A fragment library based on Gaussian mixtures predicting favorable molecular interactions

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

Quantitative structure-activity relationship of human neutrophil collagenase (MMP-8) inhibitors using comparative molecular field analysis and X-ray structure analysis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

The structure and function of proteins involved in mammalian pre-mRNA splicing

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

Total synthesis of FR901464, an antitumor agent that regulates the transcription of oncogenes and tumor suppressor genes

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

Structure-activity relationship for FR901464: a versatile method for the conversion and preparation of biologically active biotinylated probes

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801547

Substrate specificity of carboxylesterase (E.C.3.1.1.1) from several animals

31 October 2018

1 reference

12 December 2020

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1 reference

12 December 2020

Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogue

1 reference

12 December 2020

New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action

1 reference

12 December 2020

New antitumor substances, FR901463, FR901464 and FR901465. III. Structures of FR901463, FR901464 and FR901465

1 reference

12 December 2020

Three-dimensional quantitative structure-activity relationship analyses using comparative molecular field analysis and comparative molecular similarity indices analysis to elucidate selectivity differences of inhibitors binding to trypsin, thrombin,

1 reference

12 December 2020

Targeting the spliceosome

1 reference

12 December 2020

FR901464: total synthesis, proof of structure, and evaluation of synthetic analogues

1 reference

12 December 2020

Synthesis of a C4-epi-C1-C6 fragment of FR901464 using a novel bromolactolization

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM901215M

1 reference

28 July 2017

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28 July 2017

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